Sp1 trans-acting transcription factor 1 [Mus musculus] - Gene

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Summary

Official Symbol: Sp1provided by MGI
Official Full Name: trans-acting transcription factor 1provided by MGI
Primary source: MGI:98372
See related: Ensembl:ENSMUSG00000001280; Vega:OTTMUSG00000035159
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sp1-1; AA450830; AI845540; 1110003E12Rik

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Genomic context

Location :: 15 F3; 15

Sequence :: Chromosome: 15; NC_000081.6 (102406316..102436404)

See Sp1 in Epigenomics, MapViewer

Chromosome 15 - NC_000081.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MRTF-A is an important regulator of collagen synthesis in lung fibroblasts and exhibits a dependence on both SRF and Sp1 function to enhance collagen expression
Title: Myocardin-related transcription factor-A complexes activate type I collagen expression in lung fibroblasts.
Gata4 or Sp1 may limit the accessibility of the EpoR for binding of erythropoiesis-stimulating agents.
Title: Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes.
Data show that MiR-140 is co-expressed with Wwp2-C and is activated by Sox9 to target Sp1 in maintaining chondrocyte proliferation.
Title: MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation.
These data are strongly in support of Sp1 as an essential transcription factor required for Osx recruitment and transactivation of the OCN promoter.
Title: The transcriptional activity of osterix requires the recruitment of Sp1 to the osteocalcin proximal promoter.
Three GC boxes within the proximal promoter of the murine pyruvate carboxylase gene bind Sp1/Sp3
Title: Functional characterization of the proximal promoter of the murine pyruvate carboxylase gene in hepatocytes: role of multiple gc boxes.
Data suggest that ApoE associated with ApoB-carrying lipoproteins has an upregulatory role on ABCA1 expression, and that induction of Sp1 phosphorylation is a mechanism by which ApoE upregulates ABCA1 expression.
Title: A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression.
Sp1 plays a crucial role in the regulation of the dok-7 gene.
Title: The transcription factor Sp1 plays a crucial role in dok-7 gene expression.
mHtt triggers a pathogenic cascade involving Sp1 activation, which leads to REST upregulation and repression of neuronal genes
Title: Transcriptional activation of REST by Sp1 in Huntington's disease models.
miR-1224 was a negative regulator of TNF-alpha in an Sp1-dependent manner
Title: Lipopolysaccharide-induced miR-1224 negatively regulates tumour necrosis factor-α gene expression by modulating Sp1.
Site-directed mutagenesis of binding sites within the Pss1 promoter demonstrated that Sp and N-Myc synergistically activate Pss1 expression in astrocytes
Title: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells.

Submit: New GeneRIF Correction See all (108)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Reporter) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_038700.1	NC_000072.2	Tuba3a	BIND	PubMed	Sp1 interacts with Tuba3 chromatin.
NP_038700.1	NC_000072.2	Tuba3b	BIND	PubMed	Sp1 interacts with Tuba7 DNA. This interaction was modeled on a demonstrated interaction between human Sp1 and mouse Tuba7 DNA.
BioGRID:203414	BioGRID:107076	BCL6	BioGRID	PubMed	Reconstituted Complex
BioGRID:203414	BioGRID:230738	Bahd1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203414	BioGRID:219755	Bhlhe41	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:203414	BioGRID:198654	Cdkn2a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203414	BioGRID:198873	Creb1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203414	BioGRID:108201	E2F1	BioGRID	PubMed	Reconstituted Complex
BioGRID:203414	BioGRID:108202	E2F2	BioGRID	PubMed	Reconstituted Complex
BioGRID:203414	BioGRID:108203	E2F3	BioGRID	PubMed	Reconstituted Complex
BioGRID:203414	BioGRID:199350	E2f1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:203414	BioGRID:241423	Hdac1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:203414	BioGRID:200871	Jun	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203414	BioGRID:215050	Nanog	BioGRID	PubMed	Affinity Capture-MS
BioGRID:203414	BioGRID:198035	Nr0b1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:203414	BioGRID:202313	Pou5f1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:203414	BioGRID:202853	Rela	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203414	BioGRID:204323	Trp53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203414	BioGRID:113498	ZBTB16	BioGRID	PubMed	Reconstituted Complex
BioGRID:203414	BioGRID:119488	ZBTB7A	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA binding	ISO Inferred from Sequence Orthology more info
DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
HMG box domain binding	ISO Inferred from Sequence Orthology more info
RNA polymerase II core promoter proximal region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II repressing transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
core promoter proximal region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enhancer binding	IDA Inferred from Direct Assay more info	PubMed
histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
histone deacetylase binding	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleic acid binding	IEA Inferred from Electronic Annotation more info
protein C-terminus binding	ISO Inferred from Sequence Orthology more info
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
transcription factor binding	ISO Inferred from Sequence Orthology more info
transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
definitive hemopoiesis	IGI Inferred from Genetic Interaction more info	PubMed
embryonic camera-type eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
embryonic placenta development	IGI Inferred from Genetic Interaction more info	PubMed
embryonic process involved in female pregnancy	IGI Inferred from Genetic Interaction more info	PubMed
embryonic skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
enucleate erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
liver development	IGI Inferred from Genetic Interaction more info	PubMed
lung development	IGI Inferred from Genetic Interaction more info	PubMed
megakaryocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
ossification	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info	PubMed
regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
trophectodermal cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
intracellular	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: transcription factor Sp1

Names: transcription factor Sp1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013672.2 → NP_038700.2 transcription factor Sp1

Status: VALIDATED

Source sequence(s)

AC137156, AF062566, CF729889, CJ181598

Consensus CDS

CCDS37229.1

UniProtKB/TrEMBL

G3X8Q0

UniProtKB/Swiss-Prot

O89090

Related

ENSMUSP00000001326, OTTMUSP00000048941, ENSMUST00000001326, OTTMUST00000089532

Conserved Domains (2) summary

pfam13465
Location:670 – 693
Blast Score: 127

zf-H2C2_2; Zinc-finger double domain

cl15478
Location:684 – 706
Blast Score: 94

zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000081.6 Reference GRCm38 C57BL/6J

Range

102406316..102436404

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000037.1 Alternate Mm_Celera

Range

104563277..104594207

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC137156.3 (62744..92821)	None
genomic	CH466550.2	EDL03985.1	mixed
genomic	X60136.1	CAA42721.1
mRNA	AF022363.1	AAC08527.1
mRNA	AF062566.1	AAC16484.1
mRNA	AK003347.1	None	C57BL/6J
mRNA	AK088458.1	None	NOD
mRNA	CF729889.1	None	C57BL/6
mRNA	CJ181598.1	None
mRNA	EF200005.1	ABM98419.1	Swiss Webster
mRNA	EF200006.1	None	Swiss Webster
mRNA	EF200008.1	None	Swiss Webster
mRNA	S79832.1	AAB35321.1
other-genetic	BC165998.1	AAI65998.1