Sox2 SRY-box containing gene 2 [Mus musculus (house mouse)] - Gene

Summary

Go to the top of the page Help

Official Symbol: Sox2provided by MGI
Official Full Name: SRY-box containing gene 2provided by MGI
Primary source: MGI:98364
Locus tag: AL606746.1
See related: Ensembl:ENSMUSG00000074637; Vega:OTTMUSG00000021249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: lcc; ysb; Sox-2

Genomic context

Go to the top of the page Help

Location :: 3 A2-B; 3 16.93 cM

Sequence :: Chromosome: 3; NC_000069.6 (34650005..34652461)

See Sox2 in Epigenomics, MapViewer

Chromosome 3 - NC_000069.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sox2 contributes to Nkx2.1 expression in early mouse development, thus participating in the region-specific activation of Shh, thereby mediating ventral telencephalic patterning induction.
Title: Sox2 is required for embryonic development of the ventral telencephalon through the activation of the ventral determinants Nkx2.1 and Shh.
Sall4 contributes to the transcriptional network operating in pluripotent cells together with Oct-3/4 and Sox2
Title: Stemness-related factor Sall4 interacts with transcription factors Oct-3/4 and Sox2 and occupies Oct-Sox elements in mouse embryonic stem cells.
All these data suggested that over-expression of Sox2 promoted proliferation and inhibited osteoblast differentiation of C3H10T1/2 cells.
Title: Over-expression of Sox2 in C3H10T1/2 cells inhibits osteoblast differentiation through Wnt and MAPK signalling pathways.
the role of SOX2 in Epithelial-Mesenchymal Transition
Title: Silencing SOX2 induced mesenchymal-epithelial transition and its expression predicts liver and lymph node metastasis of CRC patients.
Notch is an upstream regulator of Sox2 and Prox1 in cochlear development
Title: In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation.
findings not only reveal that members of miR-200 family are unique mediators of reprogramming factors Oct4/Sox2, but also demonstrate that miR-200/ZEB2 pathway as one critical mechanism of Oct4/Sox2 to induce somatic cell reprogramming at the early stage
Title: Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation.
Loss of SOX2 Expression Leads to Defective Lung Development
Title: Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway.
A novel Sox2/survivin pathway that regulates neural stem cells survival and homoeostasis, thus revealing a new mechanism of brain development, neurological degeneration and such aging-related disorders.
Title: Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression.
show that Zscan4, expressed transiently in2-cell embryos and embryonic stem cells, efficiently produces iPSCs from mouse embryo fibroblasts when coexpressed with Klf4, Oct4, and Sox2
Title: Zscan4 transiently reactivates early embryonic genes during the generation of induced pluripotent stem cells.
data suggest that Wnt negatively regulates a SOX2-dependent signaling program required for developmental progression of the bronchiolar lineage
Title: β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium.

Submit: New GeneRIF Correction See all (131)

Alleles

Go to the top of the page Help

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (5) 1 citation
Targeted (knock-out) (4) 1 citation
Transgenic (random, gene disruption) (1) 1 citation
Targeted (Reporter) (6) 1 citation
Radiation induced (1) 1 citation
Targeted (knock-in) (4) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:203406	BioGRID:198081	Alx4	BioGRID	PubMed	Two-hybrid
BioGRID:203406	BioGRID:198512	Ctnnb1	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Suppression
BioGRID:203406	BioGRID:199504	Erg	BioGRID	PubMed	Two-hybrid
BioGRID:203406	BioGRID:199559	Eya1	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex
BioGRID:203406	BioGRID:241423	Hdac1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:203406	BioGRID:200260	Hdac2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203406	BioGRID:219943	Lin28a	BioGRID	PubMed	Co-fractionation
BioGRID:203406	BioGRID:215050	Nanog	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:203406	BioGRID:202033	Pax6	BioGRID	PubMed	Two-hybrid
BioGRID:203406	BioGRID:202313	Pou5f1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:203406	BioGRID:202560	Rad21	BioGRID	PubMed	Co-localization
BioGRID:203406	BioGRID:207998	Sae1	BioGRID	PubMed	Biochemical Activity
BioGRID:203406	BioGRID:221236	Sall4	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation
BioGRID:203406	BioGRID:203259	Six1	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex
BioGRID:203406	BioGRID:203406	Sox2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203406	BioGRID:204420	Sumo1	BioGRID	PubMed	Reconstituted Complex
BioGRID:203406	BioGRID:206169	Uba2	BioGRID	PubMed	Biochemical Activity
BioGRID:203406	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203406	BioGRID:204408	Ube2i	BioGRID	PubMed	Biochemical Activity
BioGRID:203406	BioGRID:208228	Xpo4	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex

Pathways from BioSystems

Go to the top of the page Help

Dopminergic Neurogenesis, organism-specific biosystem (from WikiPathways)
Dopminergic Neurogenesis, organism-specific biosystemhttp://www.michaeljfox.org/research_MJFFfundingPortfolio_searchableAwardedGrants_3.cfm?ID=141
Hippo signaling pathway, organism-specific biosystem (from KEGG)
Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Hippo signaling pathway, conserved biosystem (from KEGG)
Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
PluriNetWork, organism-specific biosystem (from WikiPathways)
PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...

General gene information

Go to the top of the page Help

Markers

Sox2 (e-PCR), detects polymorphism
- UniSTS:516866

Sox2 (e-PCR), detects polymorphism
- UniSTS:532256

Sox2 (e-PCR), detects polymorphism
- UniSTS:547370

Sox2 (e-PCR), detects polymorphism
- UniSTS:164916

UniSTS:471104 (e-PCR)
- UniSTS:471104

Sox2 (e-PCR), detects polymorphism
- UniSTS:471104

Sox2 (e-PCR), detects polymorphism
- UniSTS:547912

Sox2 (e-PCR), detects polymorphism
- UniSTS:547913

Sox2 (e-PCR), detects polymorphism
- UniSTS:547914

Sox2 (e-PCR), detects polymorphism
- UniSTS:474706

Sox2 (e-PCR), detects polymorphism
- UniSTS:144487

Sox2 (e-PCR), detects polymorphism
- UniSTS:508019

PMC304100P2 (e-PCR)
- UniSTS:272527

Sox2 (e-PCR), detects polymorphism
- UniSTS:499114

X94127 (e-PCR)
- UniSTS:125893

Sox2 (e-PCR), detects polymorphism
- UniSTS:532687

Homology

Homologs of the Sox2 gene: The Sox2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA binding	IGI Inferred from Genetic Interaction more info	PubMed
DNA binding	ISO Inferred from Sequence Orthology more info
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	ISO Inferred from Sequence Orthology more info
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
miRNA binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info
transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info
transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
adenohypophysis development	IMP Inferred from Mutant Phenotype more info	PubMed
anatomical structure formation involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
cell cycle arrest	ISO Inferred from Sequence Orthology more info
cell fate commitment	IDA Inferred from Direct Assay more info	PubMed
cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
detection of mechanical stimulus involved in equilibrioception	IMP Inferred from Mutant Phenotype more info	PubMed
detection of mechanical stimulus involved in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
diencephalon morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
endodermal cell fate specification	ISO Inferred from Sequence Orthology more info
epithelial tube branching involved in lung morphogenesis	IDA Inferred from Direct Assay more info	PubMed
forebrain neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
lens induction in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed
lung alveolus development	IDA Inferred from Direct Assay more info	PubMed
male genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of Wnt receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of canonical Wnt receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of canonical Wnt receptor signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
neuronal stem cell maintenance	IGI Inferred from Genetic Interaction more info
olfactory placode formation	IGI Inferred from Genetic Interaction more info	PubMed
osteoblast differentiation	ISO Inferred from Sequence Orthology more info
pigment biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
regulation of gene expression	ISO Inferred from Sequence Orthology more info
regulation of neurogenesis	IGI Inferred from Genetic Interaction more info
regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
response to chemical stimulus	IDA Inferred from Direct Assay more info	PubMed
response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
somatic stem cell maintenance	ISO Inferred from Sequence Orthology more info
stem cell differentiation	IDA Inferred from Direct Assay more info
stem cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
tongue development	IMP Inferred from Mutant Phenotype more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytosol	ISO Inferred from Sequence Orthology more info
nucleus	IC Inferred by Curator more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
transcription factor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: transcription factor SOX-2

Names: transcription factor SOX-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011443.3 → NP_035573.3 transcription factor SOX-2

Status: VALIDATED

Source sequence(s)

AK131933, AL606746, BY713734, CD353783, CD354017

Consensus CDS

CCDS38413.1

UniProtKB/Swiss-Prot

P48432

UniProtKB/TrEMBL

Q3V2B6

UniProtKB/TrEMBL

Q60I23

Related

ENSMUSP00000096755, OTTMUSP00000023485, ENSMUST00000099151, OTTMUST00000050334

Conserved Domains (2) summary

cd01388
Location:42 – 113
Blast Score: 280

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam12336
Location:112 – 202
Blast Score: 193

SOXp; SOX transcription factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000069.6 Reference GRCm38.p1 C57BL/6J

Range

34650005..34652461

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000025.1 Alternate Mm_Celera

Range

34551711..34554169

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01025465.1 (14368..16826)	None
genomic	AF118260.1	None	129/Ola
genomic	AL606746.17 (72556..75013)	None
genomic	CH466530.1	EDL35051.1	mixed
genomic	X94127.1	CAA63847.1	129
mRNA	AB108673.1	BAC75668.1	129/Ola
mRNA	AB221649.1	None
mRNA	AK131933.1	BAE20882.1	C57BL/6J
mRNA	AK149358.1	BAE28833.1	C57BL/6J
mRNA	BC057574.1	AAH57574.1	C57BL/6
mRNA	BY713734.1	None	C57BL/6J
mRNA	CD353783.1	None	C57BL/6
mRNA	CD354017.1	None	C57BL/6
mRNA	U31967.1	AAC31791.1