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    Sox13 SRY-box containing gene 13 [ Mus musculus (house mouse) ]

    Gene ID: 20668, updated on 26-Feb-2013
    Official Symbol
    Sox13provided by MGI
    Official Full Name
    SRY-box containing gene 13provided by MGI
    Primary source
    MGI:98361
    See related
    Ensembl:ENSMUSG00000070643; Vega:OTTMUSG00000026807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sox-13; AA407916; AW259412; AW540933
    Location :
    1 E4; 1
    Sequence :
    Chromosome: 1; NC_000067.6 (133382300..133424212, complement)
    See Sox13 in Epigenomics, MapViewer

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene renin 1 structural Neighboring gene ethanolamine kinase 2 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene small nuclear ribonucleoprotein E

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    2. Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Chung YC, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 20932939.
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781.
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953.
    5. Interaction between Hhex and SOX13 modulates Wnt/TCF activity. Marfil V, et al. J Biol Chem, 2010 Feb 19. PMID 20028982.

    See all (31) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the interaction between Hhex and SOX13 may contribute to control Wnt/TCF1 signaling in the early embryo.
      Title: Interaction between Hhex and SOX13 modulates Wnt/TCF activity.
    2. Sox13 identified as a gammadelta-specific gene in the immune system; it promotes gammadelta T cell development while opposing alphabeta T cell differentiation
      Title: Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13.
    3. Our data suggest a role for SOX13 in the specification and/or differentiation of a specific subset of neurons in the developing central nervous system.
      Title: SOX13 is up-regulated in the developing mouse neuroepithelium and identifies a sub-population of differentiating neurons.
    4. The temporal and spatial expression of SOX13 protein during mouse organogenesis.
      Title: SOX13 exhibits a distinct spatial and temporal expression pattern during chondrogenesis, neurogenesis, and limb development.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (Floxed/Frt) (1) 
    • Targeted (knock-out) (1)  1 citation

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    transcription factor SOX-13
    Names
    transcription factor SOX-13
    mSox13
    SRY (Sex determining region Y)-box 13

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011439.2 → NP_035569.2  transcription factor SOX-13

      Status: VALIDATED

      Source sequence(s)
      AB006329, BE949927, BE984765
      Consensus CDS
      CCDS48363.1
      UniProtKB/Swiss-Prot
      Q04891
      Related
      ENSMUSP00000119729, OTTMUSP00000033207, ENSMUST00000153799, OTTMUST00000066298
      Conserved Domains (1) summary
      cd01388
      Location:415 – 478
      Blast Score: 278
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 129S6/SvEvTac

    Genomic

    1. NT_039192.2 Reference GRCm38.p1 129S6/SvEvTac

      Range
      65135..106996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p1 C57BL/6J

      Range
      133382300..133424212, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000023.1 Alternate Mm_Celera

      Range
      135994724..136036968, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01011070.1 (83150..125394) None
    genomic AC034108.26 (96131..106992) None 129S6/SvEvTac
    genomic AC068906.14 (120634..131549) None C57BL/6J
    genomic AF057702.1 None 129
    genomic CH466520.2 EDL39645.1 mixed
      EDL39646.1 mixed
      EDL39647.1 mixed
    mRNA AB006329.1 BAA25786.1
    mRNA AJ000740.1 CAA04278.1
    mRNA BC007130.1 AAH07130.1 CZECHII
    mRNA BE949927.1 None C57BL/6J
    mRNA BE984765.1 None C57BL/6J
    mRNA Z18962.1 CAA79487.1 Swiss
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04891.4 GenPept UniProtKB/Swiss-Prot:Q04891

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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