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Sox10 SRY (sex determining region Y)-box 10 [ Mus musculus (house mouse) ]

Gene ID: 20665, updated on 6-Jul-2014
Official Symbol
Sox10provided by MGI
Official Full Name
SRY (sex determining region Y)-box 10provided by MGI
Primary source
MGI:98358
See related
Ensembl:ENSMUSG00000033006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dom; Sox21
See Sox10 in Epigenomics, MapViewer
Location:
15 E1; 15 37.7 cM
Exon count :
5
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 15 NC_000081.6 (79154909..79165235, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing -like 1 Neighboring gene RIKEN cDNA 1700088E04 gene Neighboring gene polymerase (RNA) II (DNA directed) polypeptide F Neighboring gene predicted gene 10863 Neighboring gene uncharacterized LOC102632536

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (2) 
  • Targeted (8)  1 citation
  • Radiation induced (2)  1 citation
  • Chemically induced (ENU) (2) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
digestive tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peripheral nervous system development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gliogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
transcription factor SOX-10
Names
transcription factor SOX-10
dominant megacolon
SRY-box containing gene 10
transcription factor SOX-M

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011437.1NP_035567.1  transcription factor SOX-10

    See proteins identical to NP_035567.1

    Status: VALIDATED

    Source sequence(s)
    AL591921
    Consensus CDS
    CCDS49668.1
    UniProtKB/Swiss-Prot
    Q04888
    Related
    ENSMUSP00000039466, ENSMUST00000040019
    Conserved Domains (2) summary
    cd01388
    Location:103173
    Blast Score: 283
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam12444
    Location:1194
    Blast Score: 233
    Sox_N; Sox developmental protein N terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000081.6 

    Range
    79154909..79165235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520672.1XP_006520735.1  

    See proteins identical to XP_006520735.1

    Conserved Domains (2) summary
    cd01388
    Location:206276
    Blast Score: 285
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam12444
    Location:114197
    Blast Score: 233
    Sox_N; Sox developmental protein N terminal

Alternate Mm_Celera

Genomic

  1. AC_000037.1 

    Range
    81267600..81277195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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