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    ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homo sapiens ]

    Gene ID: 2065, updated on 13-May-2012
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    Summary

    Official Symbol
    ERBB3provided by HGNC
    Official Full Name
    v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)provided by HGNC
    Primary source
    HGNC:3431
    See related
    Ensembl:ENSG00000065361; HPRD:01820; MIM:190151; Vega:OTTHUMG00000170140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033
    Summary
    This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    12q13
    Sequence :
    Chromosome: 12; NC_000012.11 (56473809..56497291)
    See ERBB3 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene IKAROS family zinc finger 4 (Eos) Neighboring gene ribosomal protein S26 Neighboring gene uncharacterized LOC100653008 Neighboring gene proliferation-associated 2G4, 38kDa Neighboring gene ribosomal protein L41

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization. Kim CK, et al. Exp Cell Res, 2012 Jan 15. PMID 21930127.
    2. Secreted ERBB3 isoforms are serum markers for early hepatoma in patients with chronic hepatitis and cirrhosis. Hsieh SY, et al. J Proteome Res, 2011 Oct 7. PMID 21877752.
    3. Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma. Takikita M, et al. J Transl Med, 2011 Jul 29. PMID 21801427.
    4. Targeting ErbB3-mediated stromal-epithelial interactions in pancreatic ductal adenocarcinoma. Liles JS, et al. Br J Cancer, 2011 Aug 9. PMID 21792199.
    5. DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib. Zhu S, et al. Gastroenterology, 2011 Nov. PMID 21741919.

    See all (210) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results indicate that stimulation of the early metastatic steps of motility and invasion by ErbB3 requires activation of the PI3-kinase pathway by the ErbB3 receptor.
      Title: Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis.
    2. HER3 is frequently localized solely in the cell nuclei in UM and as such it predicts a more favorable overall survival.
      Title: Nuclear HER3 is associated with favorable overall survival in uveal melanoma.
    3. DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib.
      Title: DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib.
    4. sERBB3 may have a role in portal-vein invasion and extrahepatic metastasis of hepatocellular carcinoma
      Title: Secreted ERBB3 isoforms are serum markers for early hepatoma in patients with chronic hepatitis and cirrhosis.
    5. EGFR mutation combined with HER2/3 expression is a significant predictor for gefitinib efficacy on Chinese patients with advanced non-small cell lung cancer.
      Title: [Correlation of epidermal growth factor receptor mutations and HER2/3 protein expression with clinical outcome in advanced non-small cell lung cancer patients treated with gefitinib].
    6. ARF6 can affect ErbB-3 nuclear localization in prostate cancer cells.
      Title: Macropinocytosis inhibitors and Arf6 regulate ErbB3 nuclear localization in prostate cancer cells.
    7. We found a significant correlation of HER2 with human epidermal growth factor receptor 3 (HER3/erbB3), epidermal growth factor receptor 1 (EGFR/HER1/erbB1) and urokinase plasminogen receptor (uPAR) in breast cancer tissues.
      Title: Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.
    8. Membranous Her3 expression is strongly associated with poor prognosis of patients with head and neck squamous cell carcinoma.
      Title: Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma.
    9. demonstrate the therapeutic potential of this approach by showing that bivalent NRG (NN) can bias signaling in HER3-expressing cancer cells, resulting in some cases in decreased migration, inhibited proliferation, and increased apoptosis
      Title: Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes.
    10. Data demonstrate that Nrdp1 preferentially associates with the nascent form of ErbB3 to accelerate its degradation, and that the two proteins colocalize at the endoplasmic reticulum.
      Title: Quantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulum.
    Submit: New GeneRIF Correction See all (132)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study.

    Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

    Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

    Lethal congenital contractural syndrome 2

    Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

    Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001973.1 NP_039258.1 NRG1    BIND  PubMed NDF-alpha interacts with Her3. An interaction between human NDF-alpha and Her3 from an unknown species was demonstrated by experimental system. 
    NP_001973.1 NP_006182.1 PA2G4    BIND  PubMed ErbB-3 interacts with EBP1. 
    P21860 P50052 AGTR2    HPRD  PubMed  
    P21860 P27701 CD82    HPRD  PubMed  
    P21860 Q00535 CDK5    HPRD  PubMed  
    P21860 P01133 EGF    HPRD  PubMed  
    P21860 P00533 EGFR    HPRD  PubMed  
    P21860 P04626 ERBB2    HPRD  PubMed  
    P21860 P21860 ERBB3    HPRD  PubMed  
    P21860 Q15303 ERBB4    HPRD  PubMed  
    P21860 P21333 FLNA    HPRD  PubMed  
    P21860 FLYWCH-type zinc finger 1 FLYWCH1    HPRD  PubMed  
    P21860 P62993 GRB2    HPRD  PubMed  
    P21860 Q14451 GRB7    HPRD  PubMed  
    P21860 P40189 IL6ST    HPRD  PubMed  
    P21860 P15941 MUC1    HPRD  PubMed  
    P21860 Q02297 NRG1    HPRD  PubMed  
    P21860 O14511 NRG2    HPRD  PubMed  
    P21860 Outer dense fiber of sperm tails 2-like ODF2L    HPRD  PubMed  
    P21860 Q9UQ80 PA2G4    HPRD  PubMed  
    P21860 P27986 PIK3R1    HPRD  PubMed  
    P21860 O00459 PIK3R2    HPRD  PubMed  
    P21860 Q15185 PTGES3    HPRD  PubMed  
    P21860 Q05397 PTK2    HPRD  PubMed  
    P21860 Q14289 PTK2B    HPRD  PubMed  
    P21860 Q13882 PTK6    HPRD  PubMed  
    P21860 O43374 RASA4    HPRD  PubMed  
    P21860 P49798 RGS4    HPRD  PubMed  
    P21860 Q9H4P4 RNF41    HPRD  PubMed  
    P21860 P29353 SHC1    HPRD  PubMed  
    P21860 Q07889 SOS1    HPRD  PubMed  
    BioGRID:108377 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:109935 CD82    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:107832 CSK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108377 BioGRID:108270 EGF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108377 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:108278 EGR1    BioGRID  PubMed PCA 
    BioGRID:108377 BioGRID:108376 ERBB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108377 BioGRID:109143 GRB7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:115330 HDAC6    BioGRID  PubMed PCA 
    BioGRID:108377 BioGRID:109786 IL6ST    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:117489 LRIG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:110669 MUC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:109332 NRG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108377 BioGRID:114917 NRG2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108377 BioGRID:121557 ODF2L    BioGRID  PubMed Two-hybrid 
    BioGRID:108377 BioGRID:111075 PA2G4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108377 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:111314 PIK3R2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108377 BioGRID:111720 PTK6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:111931 RGS4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:115488 RNF41    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:108377 BioGRID:112099 RPN1    BioGRID  PubMed PCA 
    BioGRID:108377 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108377 BioGRID:203215 Shc1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108377 BioGRID:113540 ZNF207    BioGRID  PubMed PCA 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Downregulation of ERRB2:ERBB3 signaling, organism-specific biosystem (from REACTOME)
      Downregulation of ERRB2:ERBB3 signaling, organism-specific biosystemLevel of plasma membrane ERBB3 is regulated by E3 ubiquitin ligase RNF41 (also known as NRDP1), which binds and ubiquitinates both inactive and activated ERBB3, targeting it for degradation (Cao et a...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • ErbB receptor signaling network, organism-specific biosystem (from Pathway Interaction Database)
      ErbB receptor signaling network, organism-specific biosystem
      ErbB receptor signaling network
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB2/ErbB3 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ErbB2/ErbB3 signaling events, organism-specific biosystem
      ErbB2/ErbB3 signaling events
    • GRB7 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      GRB7 events in ERBB2 signaling, organism-specific biosystemHeterodimers of ERBB2 and ERBB3 are able to bind GRB7 (Fiddes et al. 1998) through phosphorylated tyrosine residues in the C-tail of ERBB3 (Y1199 and Y1262), but the exact downstream signaling of thi...
    • Heart Development, organism-specific biosystem (from WikiPathways)
      Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
    • SHC1 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      SHC1 events in ERBB2 signaling, organism-specific biosystemAll ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ERBB4, are able to activate RAF/MAP kinase cascade by recruiting SHC1 (Pinkas-Kramarski et al. 1996, Sepp-Lorenzino et al. 1996) to phosphory...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • a6b1 and a6b4 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      a6b1 and a6b4 Integrin signaling, organism-specific biosystem
      a6b1 and a6b4 Integrin signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    growth factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    growth factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor signaling protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    Schwann cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cranial nerve development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    endocardial cushion development IEA
    Inferred from Electronic Annotation
    more info
    		  
    heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mammary gland involution IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of neuron apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    neuron apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    odontogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    peripheral nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    phosphatidylinositol 3-kinase cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of glucose import IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of phosphatidylinositol 3-kinase cascade TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    tongue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane receptor protein tyrosine kinase signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    wound healing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    receptor tyrosine-protein kinase erbB-3
    Names
    receptor tyrosine-protein kinase erbB-3
    proto-oncogene-like protein c-ErbB-3
    tyrosine kinase-type cell surface receptor HER3
    NP_001005915.1
    NP_001973.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011529.1 RefSeqGene

      Range
      4918..28400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001005915.1 → NP_001005915.1  receptor tyrosine-protein kinase erbB-3 isoform s precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (s) lacks many 3' exons found in variant 1 and contains an alternate 3' exon of its own, that causes a frameshift. The resulting isoform (s) is shorter lacking the intermembrane region present in isoform 1, and is secreted outside the cell.
      Source sequence(s)
      AC034102, M34309, S61953
      Consensus CDS
      CCDS44918.1
      UniProtKB/Swiss-Prot
      P21860
      Related
      ENSP00000415753, OTTHUMP00000243040, ENST00000411731, OTTHUMT00000407621
      Conserved Domains (1) summary
      pfam01030
      Location:56 – 124
      Blast Score: 215
      Recep_L_domain; Receptor L domain

    2. NM_001982.3 → NP_001973.2  receptor tyrosine-protein kinase erbB-3 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA524528, BC082992, BU674508, DC344156, DC347955
      Consensus CDS
      CCDS31833.1
      UniProtKB/Swiss-Prot
      P21860
      Related
      ENSP00000267101, OTTHUMP00000243039, ENST00000267101, OTTHUMT00000407619
      Conserved Domains (6) summary
      cd00064
      Location:226 – 266
      Blast Score: 109
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05111
      Location:701 – 979
      Blast Score: 1556
      PTK_HER3; Pseudokinase domain of the Protein Tyrosine Kinase, HER3
      cl00066
      Location:548 – 592
      Blast Score: 116
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:179 – 332
      Blast Score: 414
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:56 – 167
      Blast Score: 330
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:709 – 965
      Blast Score: 873
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      56473809..56497291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      53512788..53536430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC034102.32 (57955..81191) None
    genomic CH471054.1 EAW96879.1
      EAW96880.1
      EAW96881.1
      EAW96882.1
      EAW96883.1
    genomic JA454939.1 CCD32996.1
    genomic U88356.1 AAF86628.1
    mRNA AA524528.1 None
    mRNA AK124710.1 BAG54075.1
    mRNA AK125028.1 BAG54127.1
    mRNA AK291681.1 BAF84370.1
    mRNA AK294719.1 BAG57868.1
    mRNA AK295650.1 BAG58519.1
    mRNA AK300909.1 BAG62544.1
    mRNA AU100462.1 None
    mRNA BC002706.2 AAH02706.1
    mRNA BC041579.1 None
    mRNA BC082992.1 AAH82992.1
    mRNA BM837872.1 None
    mRNA BT007226.1 AAP35890.1
    mRNA BU674508.1 None
    mRNA BX641868.1 None
    mRNA DC344156.1 None
    mRNA DC347955.1 None
    mRNA M29366.1 AAA35790.1
    mRNA M34309.1 AAA35979.1
    mRNA S61953.1 AAB26935.1
    mRNA U88357.1 AAC39857.1
    mRNA U88358.1 AAC39858.1
    mRNA U88359.1 AAC39859.1
    mRNA U88360.1 AAC39860.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75810 GenPept UniProtKB/TrEMBL:O75810
    O75811 GenPept UniProtKB/TrEMBL:O75811
    O75812 GenPept UniProtKB/TrEMBL:O75812
    O75813 GenPept UniProtKB/TrEMBL:O75813
    P21860.1 GenPept UniProtKB/Swiss-Prot:P21860
    Q9NNX2 GenPept UniProtKB/TrEMBL:Q9NNX2
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