Snrpb2 U2 small nuclear ribonucleoprotein B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snrpb2provided by MGI
Official Full Name: U2 small nuclear ribonucleoprotein Bprovided by MGI
Primary source: MGI:MGI:104805
See related: Ensembl:ENSMUSG00000008333 AllianceGenome:MGI:104805
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810052G09Rik
Summary: Predicted to enable U1 snRNA binding activity and snRNP binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytoplasmic ribonucleoprotein granule; fibrillar center; and nuclear speck. Predicted to be part of nucleus. Is expressed in 8-cell stage embryo; brain; submandibular gland primordium; and vibrissa. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPB2 (small nuclear ribonucleoprotein polypeptide B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 38.4), CNS E14 (RPKM 22.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G1; 2 70.89 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (142904989..142913972)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (143063069..143072052)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Snrpb2 (e-PCR), detects polymorphism
- UniSTS:536604

Snrpb2 (e-PCR), detects polymorphism
- UniSTS:536605

Snrpb2 (e-PCR), detects polymorphism
- UniSTS:479276

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables U1 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables snRNP binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of U1 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U2 snRNP	ISO Inferred from Sequence Orthology more info
part_of U2-type catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type precatalytic spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of small nuclear ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: U2 small nuclear ribonucleoprotein B''

Names: U2 snRNP B''

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021335.3 → NP_067310.1 U2 small nuclear ribonucleoprotein B''

See identical proteins and their annotated locations for NP_067310.1

Status: PROVISIONAL

Source sequence(s)

AK013871

Consensus CDS

CCDS16808.1

UniProtKB/Swiss-Prot

Q9CQI7, Q9CW35, Q9CZ66

Related

ENSMUSP00000008477.7, ENSMUST00000008477.13

Conserved Domains (2) summary

cd12478
Location:6 → 96

RRM1_U2B; RNA recognition motif 1 in U2 small nuclear ribonucleoprotein B" (U2B") and similar proteins

cd12481
Location:146 → 225

RRM2_U2B; RNA recognition motif 2 found in vertebrate U2 small nuclear ribonucleoprotein B" (U2B")