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Snrnp70 small nuclear ribonucleoprotein 70 (U1) [ Mus musculus (house mouse) ]

Gene ID: 20637, updated on 28-May-2016
Official Symbol
Snrnp70provided by MGI
Official Full Name
small nuclear ribonucleoprotein 70 (U1)provided by MGI
Primary source
MGI:MGI:98341
See related
Ensembl:ENSMUSG00000063511
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U1-70; R74807; Snrp70; Srnp70; U1-70K; Rnu1p70; Rnulp70; AI325098; 2700022N21Rik; 3200002N22Rik
Summary
This gene encodes a subunit of the U1 snRNP (small nuclear ribonucleic particle), one of at least five snRNPs to comprise the spliceosome, which functions in processing of pre-mRNAs. The U1 snRNP has been shown to be important in defining the 5' splice site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Orthologs
Location:
7 B4; 7 29.28 cM
Exon count:
14
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (45376454..45395742, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (52631824..52651017, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 Neighboring gene metastasis associated gene 2 Neighboring gene lin-7 homolog B (C. elegans) Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 7 Neighboring gene neurotrophin 5

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding ISO
Inferred from Sequence Orthology
more info
 
U1 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
U1 snRNP binding ISO
Inferred from Sequence Orthology
more info
 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
 
U1 snRNP ISO
Inferred from Sequence Orthology
more info
 
U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
commitment complex IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
U1 small nuclear ribonucleoprotein 70 kDa
Names
U1 small nuclear ribonucleoprotein 70 kDa polypeptide A
U1 snRNP 70 kDa

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009224.5NP_033250.3  U1 small nuclear ribonucleoprotein 70 kDa

    See identical proteins and their annotated locations for NP_033250.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the protein.
    Source sequence(s)
    AK005045, AK148013, BE990366, BY297843
    Consensus CDS
    CCDS21240.1
    UniProtKB/Swiss-Prot
    Q62376
    UniProtKB/TrEMBL
    A2RS68
    Related
    ENSMUSP00000074160, ENSMUST00000074575
    Conserved Domains (3) summary
    smart00360
    Location:104176
    RRM; RNA recognition motif
    cd12236
    Location:102187
    RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
    pfam12220
    Location:195
    U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal

RNA

  1. NR_126538.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK005045, AK148013, BC049128, BE990366, BY297843
  2. NR_126539.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC049128, BE990366, BY297843

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    45376454..45395742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540732.2XP_006540795.1  

    See identical proteins and their annotated locations for XP_006540795.1

    UniProtKB/Swiss-Prot
    Q62376
    UniProtKB/TrEMBL
    A2RS68
    Conserved Domains (3) summary
    smart00360
    Location:104176
    RRM; RNA recognition motif
    cd12236
    Location:102187
    RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
    pfam12220
    Location:195
    U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
  2. XM_006540733.2XP_006540796.1  

    See identical proteins and their annotated locations for XP_006540796.1

    Conserved Domains (3) summary
    smart00360
    Location:104176
    RRM; RNA recognition motif
    cd12236
    Location:102192
    RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
    pfam12220
    Location:195
    U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
  3. XM_011250831.1XP_011249133.1  

    See identical proteins and their annotated locations for XP_011249133.1

    Conserved Domains (3) summary
    smart00360
    Location:104176
    RRM; RNA recognition motif
    cd12236
    Location:102192
    RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
    pfam12220
    Location:195
    U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    40832480..40851770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)