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Plk2 polo-like kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 20620, updated on 8-May-2016
Official Symbol
Plk2provided by MGI
Official Full Name
polo-like kinase 2provided by MGI
Primary source
MGI:MGI:1099790
See related
Ensembl:ENSMUSG00000021701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Snk
Orthologs
Location:
13; 13 D2.1
Exon count:
14
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (110395044..110400844)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (111185252..111191052)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41058 Neighboring gene Grb2-binding adaptor, transmembrane Neighboring gene predicted gene, 32990 Neighboring gene predicted gene, 33045

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
Rap protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
long term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
centriole ISO
Inferred from Sequence Orthology
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
serine/threonine-protein kinase PLK2
Names
PLK-2
serine/threonine-protein kinase SNK
serum-inducible kinase
NP_690017.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152804.2NP_690017.2  serine/threonine-protein kinase PLK2

    See identical proteins and their annotated locations for NP_690017.2

    Status: VALIDATED

    Source sequence(s)
    AK160441, AK164365, BM947259, BP765662, CJ063842
    Consensus CDS
    CCDS26767.1
    UniProtKB/Swiss-Prot
    P53351
    UniProtKB/TrEMBL
    Q3TV29, Q548A9
    Related
    ENSMUSP00000022212, ENSMUST00000022212
    Conserved Domains (4) summary
    smart00220
    Location:79331
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13117
    Location:598679
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:500585
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14188
    Location:77331
    STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    110395044..110400844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    114729888..114735651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)