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    Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin [ Mus musculus ]

    Gene ID: 20612, updated on 13-May-2012
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    Summary

    Official Symbol
    Siglec1provided by MGI
    Official Full Name
    sialic acid binding Ig-like lectin 1, sialoadhesinprovided by MGI
    Primary source
    MGI:99668
    Locus tag
    RP23-228H14.5
    See related
    Ensembl:ENSMUSG00000027322; Vega:OTTMUSG00000015684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sn; Cd169; Siglec-1
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    Genomic context

    Location :
    2 F-H1; 2 73.9 cM
    Sequence :
    Chromosome: 2; NC_000068.7 (131069220..131086765, complement)
    See Siglec1 in Epigenomics, MapViewer

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 4 Neighboring gene a disintegrin and metallopeptidase domain 33 Neighboring gene heat shock protein 12B Neighboring gene RIKEN cDNA 1700037H04 gene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase. Ravishankar B, et al. Proc Natl Acad Sci U S A, 2012 Mar 6. PMID 22355111.
    2. Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. Muppidi JR, et al. J Exp Med, 2011 Sep 26. PMID 21875957.
    3. Absence of Nkx2-3 homeodomain transcription factor induces the formation of LYVE-1-positive endothelial cysts without lymphatic commitment in the spleen. Kellermayer Z, et al. J Histochem Cytochem, 2011 Jul. PMID 21705651.
    4. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. Chow A, et al. J Exp Med, 2011 Feb 14. PMID 21282381.
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.

    See all (34) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. CD169+ macrophage-depleted mice fail to crossprime tumor-specific CD8 T cells
      Title: CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens.
    2. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.
      Title: Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.
    3. This indicates that Sn is expressed on mouse alveolar macrophages but that the sialic acid binding activity mediated by this molecule is naturally masked by endogenous sialic acid within the glycocalyx on the cell surface.
      Title: Analysis of sialoadhesin expression on mouse alveolar macrophages.
    4. The significant activation of microglia/macrophages observed in the various stages of degeneration in rd1 and rds mouse retinas is not accompanied by Sn expression.
      Title: Sialoadhesin expression in intact degenerating retinas and following transplantation.
    5. in a primarily genetically caused myelin disorder of the CNS macrophages expressing sialoadhesin partially mediate pathogenesis
      Title: Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice.
    6. role for sialoadhesin in regulating cells of the immune system rather than in influencing steady-state hematopoiesis
      Title: Sialoadhesin-deficient mice exhibit subtle changes in B- and T-cell populations and reduced immunoglobulin M levels.
    7. Plays a role in fine tuning the immune response to autoantigens by modulating T cell priming.
      Title: Sialoadhesin promotes the inflammatory response in experimental autoimmune uveoretinitis.
    8. Results describe the role of the macrophage-restricted sialic acid-binding Ig-like lectin sialoadhesin (Sn, Siglec-1) in the pathogenesis of inherited demyelination in myelin P0(+/-) mice.
      Title: Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in P0.
    9. Using flow cytometry of sialoadhesin-transfected cells, antigen recognized by MOMA-1 is sialoadhesin
      Title: The antigen recognized by MOMA-I is sialoadhesin.
    10. Sn acts as an endogenous counter-receptor for MGL1
      Title: Identification of sialoadhesin as a dominant lymph node counter-receptor for mouse macrophage galactose-type C-type lectin 1.
    Submit: New GeneRIF Correction See all (12)
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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:203360 BioGRID:1205537 gag    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sugar binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    sialoadhesin
    Names
    sialoadhesin
    SER
    sheep erythrocyte receptor
    sialic acid-binding Ig-like lectin 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011426.3 → NP_035556.3  sialoadhesin precursor

      Status: VALIDATED

      Source sequence(s)
      AA396073, BC141335, Z36293
      Consensus CDS
      CCDS16754.2
      UniProtKB/TrEMBL
      G3X8X6
      UniProtKB/Swiss-Prot
      Q62230
      Related
      ENSMUSP00000028794, OTTMUSP00000016700, ENSMUST00000028794, OTTMUST00000037285
      Conserved Domains (4) summary
      cd00096
      Location:437 – 511
      Blast Score: 117
      Ig; Immunoglobulin domain
      cd05712
      Location:27 – 136
      Blast Score: 436
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      pfam07679
      Location:422 – 511
      Blast Score: 140
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:338 – 415
      Blast Score: 110
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38 C57BL/6J

      Range
      131069220..131086765, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      132293968..132311385, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AF155960.1 (1..10030) None 129
    genomic AL831736.16 (2000..18386) None
    genomic AL833771.4 CAM18034.1
    genomic CH466519.1 EDL28299.1 mixed
      EDL28300.1 mixed
    genomic U92833.1 AAB95641.1
    genomic U92834.1 AAB95641.1
    genomic U92835.1 None
    genomic U92836.1 AAB95641.1
    genomic U92837.1 AAB95641.1
    genomic U92838.1 AAB95641.1
    genomic U92839.1 AAB95641.1
    genomic U92840.1 AAB95641.1
    genomic U92841.1 AAB95641.1
    genomic U92842.1 AAB95641.1
    genomic U92843.1 None
    mRNA AA396073.1 None C57BL/6J
    mRNA AK131121.1 BAD21371.1
    mRNA BC141335.1 AAI41336.1
    mRNA BC141336.1 AAI41337.1
    mRNA Z36233.1 CAA85268.1 C57BL/6
    mRNA Z36234.1 CAA85269.1 C57BL/6
    mRNA Z36293.1 CAA85290.1 C57BL/6
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62230.2 GenPept UniProtKB/Swiss-Prot:Q62230
    Q6KAT6 GenPept UniProtKB/TrEMBL:Q6KAT6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials
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