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Sstr2 somatostatin receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 20606, updated on 8-May-2016
Official Symbol
Sstr2provided by MGI
Official Full Name
somatostatin receptor 2provided by MGI
Primary source
MGI:MGI:98328
See related
Ensembl:ENSMUSG00000047904 Vega:OTTMUSG00000003400
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SS2R; sst2; SRIF-1; SSTR-2; Smstr2; Smstr-2
Summary
The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several hormones and other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, including adenylyl cyclase inhibition, phosphotyrosine phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Orthologs
Location:
11 E2; 11 79.05 cM
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (113619481..113625895)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (113485571..113486950)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39505 Neighboring gene solute carrier family 39 (metal ion transporter), member 11 Neighboring gene predicted gene, 42094 Neighboring gene family with sequence similarity 104, member A Neighboring gene component of oligomeric golgi complex 1 Neighboring gene DNA segment, Chr 11, Wayne State University 47, expressed Neighboring gene cleavage and polyadenylation specific factor 4-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
somatostatin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
somatostatin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatostatin receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to estradiol stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to glucocorticoid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
peristalsis ISO
Inferred from Sequence Orthology
more info
 
regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
somatostatin receptor type 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042606.2NP_001036071.1  somatostatin receptor type 2 isoform A

    See identical proteins and their annotated locations for NP_001036071.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an exon and its transcription extends past a splice site that is used in variant 2. This results in a novel 3' coding region and 3' UTR, compared to variant 2. It encodes isoform A which is longer and has a distinct C-terminus, compared to isoform B.
    Source sequence(s)
    AL603705
    Consensus CDS
    CCDS59571.1
    UniProtKB/Swiss-Prot
    P30875
    Related
    ENSMUSP00000138101, OTTMUSP00000065122, ENSMUST00000146390, OTTMUST00000007141
    Conserved Domains (2) summary
    pfam00001
    Location:66312
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:54327
    7tm_4; Olfactory receptor
  2. NM_009217.4NP_033243.2  somatostatin receptor type 2 isoform B

    See identical proteins and their annotated locations for NP_033243.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the shorter isoform (B).
    Source sequence(s)
    AL603705
    Consensus CDS
    CCDS25598.1
    UniProtKB/Swiss-Prot
    P30875
    Related
    ENSMUSP00000102241, OTTMUSP00000003405, ENSMUST00000106630, OTTMUST00000007140
    Conserved Domains (2) summary
    pfam00001
    Location:66312
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:54327
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    113619481..113625895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    125374928..125390905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)