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Ighmbp2 immunoglobulin mu binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 20589, updated on 28-May-2016
Official Symbol
Ighmbp2provided by MGI
Official Full Name
immunoglobulin mu binding protein 2provided by MGI
Primary source
MGI:MGI:99954
See related
Ensembl:ENSMUSG00000024831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AEP; nmd; sma; Catf1; Smbp2; Smbp-2; Smubp2; RIPE3b1
Orthologs
Location:
19 A; 19 3.03 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (3259076..3283010, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (3259076..3283010, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene Crn, crooked neck-like 1 pseudogene Neighboring gene zinc finger protein 384 pseudogene Neighboring gene mitochondrial ribosomal protein L21 Neighboring gene microRNA 6984 Neighboring gene carnitine palmitoyltransferase 1a, liver Neighboring gene predicted gene, 36532

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATP-dependent 5'-3' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
ATP-dependent 5'-3' RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
ATP-dependent helicase activity IEA
Inferred from Electronic Annotation
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-dependent ATPase activity ISO
Inferred from Sequence Orthology
more info
 
G-rich single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA-dependent ATPase activity ISO
Inferred from Sequence Orthology
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
ribosome binding ISO
Inferred from Sequence Orthology
more info
 
tRNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
neuromuscular process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
intracellular ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
DNA-binding protein SMUBP-2
Names
ATP-dependent helicase IGHMBP2
antifreeze enhancer-binding protein
cardiac transcription factor 1
immunoglobulin S mu binding protein 2
immunoglobulin mu-binding protein 2
neuromuscular degeneration
p110 subunit
NP_033238.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009212.2NP_033238.2  DNA-binding protein SMUBP-2

    See identical proteins and their annotated locations for NP_033238.2

    Status: VALIDATED

    Source sequence(s)
    AC148174, AL626765
    Consensus CDS
    CCDS29393.1
    UniProtKB/TrEMBL
    A0A0B4J1E3
    Related
    ENSMUSP00000025751, OTTMUSP00000035661, ENSMUST00000025751, OTTMUST00000070065
    Conserved Domains (5) summary
    cd02641
    Location:724782
    R3H_Smubp-2_like; R3H domain of Smubp-2_like proteins. Smubp-2_like proteins also contain a helicase_like and an AN1-like Zinc finger domain and have been shown to bind single-stranded DNA. The name of the R3H domain comes from the characteristic spacing of the most ...
    smart00154
    Location:895935
    ZnF_AN1; AN1-like Zinc finger
    cd00046
    Location:210292
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam13087
    Location:417613
    AAA_12; AAA domain
    TIGR00376
    Location:19640
    TIGR00376; DNA helicase, putative

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    3259076..3283010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531702.1XP_006531765.1  

    Conserved Domains (3) summary
    cd02641
    Location:303361
    R3H_Smubp-2_like; R3H domain of Smubp-2_like proteins. Smubp-2_like proteins also contain a helicase_like and an AN1-like Zinc finger domain and have been shown to bind single-stranded DNA. The name of the R3H domain comes from the characteristic spacing of the most ...
    smart00154
    Location:474514
    ZnF_AN1; AN1-like Zinc finger
    pfam13087
    Location:1192
    AAA_12; AAA domain
  2. XM_006531701.1XP_006531764.1  

    Conserved Domains (3) summary
    cd00046
    Location:210292
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam13087
    Location:417613
    AAA_12; AAA domain
    TIGR00376
    Location:19635
    TIGR00376; DNA helicase, putative

RNA

  1. XR_388253.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    3128514..3152444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)