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Slit3 slit homolog 3 (Drosophila) [ Mus musculus (house mouse) ]

Gene ID: 20564, updated on 8-May-2016
Official Symbol
Slit3provided by MGI
Official Full Name
slit homolog 3 (Drosophila)provided by MGI
Primary source
MGI:MGI:1315202
See related
Ensembl:ENSMUSG00000056427 Vega:OTTMUSG00000005411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Slil2; Slit1; b2b2362.1Clo
Orthologs
Location:
11; 11 A5
Exon count:
36
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (35121456..35708507)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (34934958..35522009)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene spindle apparatus coiled-coil protein 1 Neighboring gene predicted gene, 33277 Neighboring gene predicted gene, 33453 Neighboring gene predicted gene, 39708 Neighboring gene predicted gene, 42069 Neighboring gene predicted gene, 39705 Neighboring gene microRNA 218-2 Neighboring gene microRNA 103-1 Neighboring gene predicted gene, 39711 Neighboring gene pantothenate kinase 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Roundabout binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Roundabout binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Roundabout signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Roundabout signaling pathway ISO
Inferred from Sequence Orthology
more info
 
axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
axon guidance ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
organ morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with mitochondrion ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
slit homolog 3 protein
Names
slit-3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011412.3NP_035542.2  slit homolog 3 protein precursor

    See identical proteins and their annotated locations for NP_035542.2

    Status: VALIDATED

    Source sequence(s)
    AF088902, AK147292, BB645429, BC150780
    Consensus CDS
    CCDS24542.1
    UniProtKB/Swiss-Prot
    Q9WVB4
    UniProtKB/TrEMBL
    B2RX06, Q3UHN1, Q9Z0Y6
    Related
    ENSMUSP00000066857, OTTMUSP00000005590, ENSMUST00000069837, OTTMUST00000012061
    Conserved Domains (11) summary
    pfam01462
    Location:3360
    LRRNT; Leucine rich repeat N-terminal domain
    smart00013
    Location:725756
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:857906
    LRRCT; Leucine rich repeat C-terminal domain
    cd00054
    Location:10761110
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:11591312
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00116
    Location:49220
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam00008
    Location:11241153
    EGF; EGF-like domain
    pfam12799
    Location:331371
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:775835
    LRR_8; Leucine rich repeat
    cl21545
    Location:14631519
    GHB_like; Glycoprotein hormone beta chain homologues
    sd00033
    Location:6486
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    35121456..35708507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    38900451..39489864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)