Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 [Mus musculus] - Gene

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Summary

Official Symbol: Slc9a1provided by MGI
Official Full Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1provided by MGI
Primary source: MGI:102462
Locus tag: RP23-32C12.6
See related: Ensembl:ENSMUSG00000028854; Vega:OTTMUSG00000011153
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: swe; Apnh; Nhe1; AW554487

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Genomic context

Location :: 4 D3-E; 4 64.6 cM

Sequence :: Chromosome: 4; NC_000070.6 (133369772..133423698)

See Slc9a1 in Epigenomics, MapViewer

Chromosome 4 - NC_000070.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

According to the present observations, SGK1 is a major determinant of NHE1 activity in the failing heart.
Title: Sgk1 sensitivity of Na(+)/H(+) exchanger activity and cardiac remodeling following pressure overload.
Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival
Title: Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival.
functional NHE2, but not NHE1, is essential for mouse gastric epithelial restitution and TFFs activate epithelial repair via NHE2
Title: Trefoil factor 2 requires Na/H exchanger 2 activity to enhance mouse gastric epithelial repair.
expression of activated NHE1 promotes greater sensitivity to neurohormonal stimulation
Title: Activated NHE1 is required to induce early cardiac hypertrophy in mice.
Inhibiting the Na+/H+ exchanger reduces reperfusion injury.
Title: Inhibiting the Na+/H+ exchanger reduces reperfusion injury: a small animal MRI study.
Expression of activated NHE1 elicits specific pathways of gene activation in the myocardium that lead to cardiac hypertrophy, cell death and infarction.
Title: Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy.
The study suggests that NHE-1 functions to maintain microglial pH(i) homeostasis allowing for sustained NADPH oxidase function and "respiratory" burst.
Title: Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis.
Nedd4-1 and beta-arrestin-1 as key regulators of NHE1 ubiquitylation, endocytosis, and function.
Title: Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and function.
Reperfusion triggers a transient stimulation of ribosomal protein S6 kinase 90kD 1 (p90RSK) pathway which contributes to cerebral ischemic damage in part via phosphorylation of NHE-1 protein.
Title: p90 activation contributes to cerebral ischemic damage via phosphorylation of Na+/H+ exchanger isoform 1.
the results of this study indicates that NHE1 participates in the regulation of early neurite morphogenesis and identify a novel role for NHE1 in the promotion of early neurite outgrowth by netrin-1.
Title: Regulation of early neurite morphogenesis by the Na+/H+ exchanger NHE1.

Submit: New GeneRIF Correction See all (41)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation
Spontaneous (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:203321	BioGRID:224960	Arrb1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203321	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203321	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
antiporter activity	IEA Inferred from Electronic Annotation more info
sodium:hydrogen antiporter activity	IDA Inferred from Direct Assay more info	PubMed
sodium:hydrogen antiporter activity	ISO Inferred from Sequence Orthology more info
solute:hydrogen antiporter activity	IEA Inferred from Electronic Annotation more info
transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
cation transport	IEA Inferred from Electronic Annotation more info
intracellular protein kinase cascade	ISO Inferred from Sequence Orthology more info
ion transmembrane transport	IEA Inferred from Electronic Annotation more info
ion transport	IEA Inferred from Electronic Annotation more info
positive regulation of anti-apoptosis	ISO Inferred from Sequence Orthology more info
proton transport	IEA Inferred from Electronic Annotation more info
proton transport	ISO Inferred from Sequence Orthology more info
regulation of pH	IDA Inferred from Direct Assay more info	PubMed
regulation of pH	IMP Inferred from Mutant Phenotype more info	PubMed
response to acid	IMP Inferred from Mutant Phenotype more info	PubMed
response to acidity	IMP Inferred from Mutant Phenotype more info	PubMed
response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
transmembrane transport	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
basolateral plasma membrane	TAS Traceable Author Statement more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
intracellular	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
membrane fraction	IDA Inferred from Direct Assay more info	PubMed
membrane raft	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: sodium/hydrogen exchanger 1

Names: sodium/hydrogen exchanger 1; NHE-1; Na+/H+ antiporter; slow-wave epilepsy; Na(+)/H(+) exchanger 1; Na+/H+, amiloride sensitive; solute carrier family 9 member 1; solute carrier family 9, member 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016981.2 → NP_058677.1 sodium/hydrogen exchanger 1

Status: VALIDATED

Source sequence(s)

AK150135, AK165501

Consensus CDS

CCDS38903.1

UniProtKB/TrEMBL

Q3TN68

UniProtKB/TrEMBL

Q3UDC9

UniProtKB/Swiss-Prot

Q61165

Related

ENSMUSP00000030669, OTTMUSP00000011959, ENSMUST00000030669, OTTMUST00000026125

Conserved Domains (2) summary

TIGR00840
Location:99 – 664
Blast Score: 1945

b_cpa1; sodium/hydrogen exchanger 3

cl10482
Location:194 – 519
Blast Score: 90

KefB; Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000070.6 Reference GRCm38 C57BL/6J

Range

133369772..133423698

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000026.1 Alternate Mm_Celera

Range

131535491..131589316

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL671882.6	CAM21074.1
genomic	CH466552.2	EDL30069.1	mixed
		EDL30070.1	mixed
mRNA	AK150135.1	BAE29332.1	C57BL/6J
mRNA	AK154857.1	BAE32882.1	NOD
mRNA	AK162209.1	None	C57BL/6J
mRNA	AK165501.1	BAE38221.1	C57BL/6J
mRNA	AK197072.1	None
mRNA	BC004687.1	AAH04687.1	CZECHII
mRNA	BC051431.1	AAH51431.1	FVB/N
mRNA	BC052708.1	AAH52708.1	C57BL/6
mRNA	U51112.1	AAA92976.1	BALB/c

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q3TN68	GenPept	UniProtKB/TrEMBL:Q3TN68
Q3U3A6	GenPept	UniProtKB/TrEMBL:Q3U3A6
Q3UDC9	GenPept	UniProtKB/TrEMBL:Q3UDC9
Q61165.1	GenPept	UniProtKB/Swiss-Prot:Q61165
Q7TSV2	GenPept	UniProtKB/TrEMBL:Q7TSV2
Q80X31	GenPept	UniProtKB/TrEMBL:Q80X31
Q99KF4	GenPept	UniProtKB/TrEMBL:Q99KF4