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STX2 syntaxin 2 [ Homo sapiens (human) ]

Gene ID: 2054, updated on 11-Sep-2014
Official Symbol
STX2provided by HGNC
Official Full Name
syntaxin 2provided by HGNC
Primary source
HGNC:HGNC:3403
See related
Ensembl:ENSG00000111450; HPRD:11816; MIM:132350; Vega:OTTHUMG00000168365
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPM; EPIM; STX2A; STX2B; STX2C
Summary
The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
See STX2 in Epigenomics, MapViewer
Location:
12q24.33
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (130789600..130839274, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (131274145..131323819, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724010 Neighboring gene RIMS binding protein 2 Neighboring gene peripheral-type benzodiazepine receptor-associated protein 1-like Neighboring gene RAN, member RAS oncogene family Neighboring gene G protein-coupled receptor 133

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC51014

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acrosome reaction ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
ectoderm development TAS
Traceable Author Statement
more info
PubMed 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
regulation of blood coagulation IMP
Inferred from Mutant Phenotype
more info
 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
syntaxin-2
Names
syntaxin-2
epimorphin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001980.3NP_001971.2  syntaxin-2 isoform 1

    See proteins identical to NP_001971.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC073912, BC047496, DB474363
    Consensus CDS
    CCDS9269.1
    UniProtKB/Swiss-Prot
    P32856
    Related
    ENSP00000261653, OTTHUMP00000238636, ENST00000261653, OTTHUMT00000399454
    Conserved Domains (2) summary
    cd00179
    Location:29180
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd00193
    Location:194253
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...
  2. NM_194356.2NP_919337.1  syntaxin-2 isoform 2

    See proteins identical to NP_919337.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional segment in the coding region, compared to variant 1. The resulting isoform (2) contains a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073912, BC047496, CN418753, DB474363
    Consensus CDS
    CCDS9270.1
    UniProtKB/Swiss-Prot
    P32856
    Conserved Domains (2) summary
    cd00179
    Location:29180
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd00193
    Location:194253
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    130789600..130839274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253557.1XP_005253614.1  

    Conserved Domains (2) summary
    cd00179
    Location:29180
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd00193
    Location:194253
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...
  2. XM_006719276.1XP_006719339.1  

    Conserved Domains (2) summary
    cd00179
    Location:1152
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd00193
    Location:166225
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...
  3. XM_005253556.2XP_005253613.1  

    See proteins identical to XP_005253613.1

    UniProtKB/Swiss-Prot
    P32856
    Conserved Domains (2) summary
    cd00179
    Location:29180
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd00193
    Location:194253
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    128256936..128306689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    131094820..131144677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)