Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Slc2a2provided by MGI
Official Full Name: solute carrier family 2 (facilitated glucose transporter), member 2provided by MGI
Primary source: MGI:1095438
See related: Ensembl:ENSMUSG00000027690; Vega:OTTMUSG00000035916
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glut2; Glut-2; AI266973

Genomic context

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Location :: 3 A3; 3 12.19 cM

Sequence :: Chromosome: 3; NC_000069.6 (28697903..28728361)

See Slc2a2 in Epigenomics, MapViewer

Chromosome 3 - NC_000069.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

In contrast to islets from the most widely used T1D model, the NOD mouse, human islets predominantly express GLUT1 and, to a much lesser extent, GLUT3 on their surface instead of GLUT2.
Title: Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals.
In human enterocytes, GLUT2 was consistently located in basolateral membranes; mice on a low-carbohydrate/high-fat diet for 12 months also exhibited endosomal GLUT2 accumulation and reduced glucose absorption.
Title: GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice.
Our data provide evidence that glucose detection by GLUT2 contributes to the control of food intake by the hypothalamus
Title: Detection of extracellular glucose by GLUT2 contributes to hypothalamic control of food intake.
regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents
Title: Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents.
The regulation of SGLT-1 and GLUT2 by RELM-beta expands the role of gut hormones in short-term AMPK/protein kinase C mediated control of energy balance
Title: Resistin-like molecule-beta inhibits SGLT-1 activity and enhances GLUT2-dependent jejunal glucose transport.
mRNA expression of GLUT2 varied diurnally in the duodenum, jejunum and ileum mucosa. GLUT2 protein level varied diurnally in duodenum and jejunum, but not in the ileum.
Title: Hexose transporter expression and function in mouse small intestine: role of diurnal rhythm.
endocytosis and degradation of GLUT2 was specific for beta-cells because expression of GLUT2 in 3T3L1 adipocytes remained cell surface localized and did not display a rapid rate of degradation.
Title: The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner.
we propose the increase in insulin recptor A/GLUT2 complexes due to PTP1B deficiency as the molecular mechanism of the increased glucose uptake in the neonatal stage.
Title: PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.
Molecular invalidation of sugar sensing in GLUT2-loop transgenic mice changed multiple aspects of glucose homeostasis, highlighting by a top-down approach, the role of membrane glucose receptors as potential therapeutic targets
Title: Loss of sugar detection by GLUT2 affects glucose homeostasis in mice.
Acute insulin treatment before sugar intake prevented the insertion of GLUT2 into the brush border membrane of enterocytes.
Title: Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice.

Submit: New GeneRIF Correction See all (22)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

Pathways from BioSystems

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Carbohydrate digestion and absorption, organism-specific biosystem (from KEGG)
Carbohydrate digestion and absorption, organism-specific biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
Carbohydrate digestion and absorption, conserved biosystem (from KEGG)
Carbohydrate digestion and absorption, conserved biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Facilitative Na+-independent glucose transporters, organism-specific biosystem (from REACTOME)
Facilitative Na+-independent glucose transporters, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glucose transport, organism-specific biosystem (from REACTOME)
Glucose transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glycolysis and Gluconeogenesis, organism-specific biosystem (from WikiPathways)
Glycolysis and Gluconeogenesis, organism-specific biosystem
Glycolysis and Gluconeogenesis
Hexose transport, organism-specific biosystem (from REACTOME)
Hexose transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin secretion, organism-specific biosystem (from KEGG)
Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
Integration of energy metabolism, organism-specific biosystem (from REACTOME)
Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Maturity onset diabetes of the young, organism-specific biosystem (from KEGG)
Maturity onset diabetes of the young, organism-specific biosystemAbout 2-5% of type II diabetic patients suffer from a monogenic disease with autosomal dominant inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young (MO...
Maturity onset diabetes of the young, conserved biosystem (from KEGG)
Maturity onset diabetes of the young, conserved biosystemAbout 2-5% of type II diabetic patients suffer from a monogenic disease with autosomal dominant inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young (MO...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
Metabolism of carbohydrates, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Insulin Secretion, organism-specific biosystem (from REACTOME)
Regulation of Insulin Secretion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of beta-cell development, organism-specific biosystem (from REACTOME)
Regulation of beta-cell development, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of gene expression in beta cells, organism-specific biosystem (from REACTOME)
Regulation of gene expression in beta cells, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
SLC-mediated transmembrane transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystem (from REACTOME)
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Type II diabetes mellitus, organism-specific biosystem (from KEGG)
Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
Type II diabetes mellitus, conserved biosystem (from KEGG)
Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...

General gene information

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Markers

Slc2a2 (e-PCR), detects polymorphism
- UniSTS:144423

Slc2a2 (e-PCR), detects polymorphism
- UniSTS:532567

AI266973 (e-PCR)
- UniSTS:178817

PMC86965P1 (e-PCR)
- UniSTS:273567

D3Mit268 (e-PCR), detects polymorphism
- UniSTS:129696

Slc2a2 (e-PCR), detects polymorphism
- UniSTS:546002

Homology

Homologs of the Slc2a2 gene: The Slc2a2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
dehydroascorbic acid transporter activity	IDA Inferred from Direct Assay more info	PubMed
dehydroascorbic acid transporter activity	ISO Inferred from Sequence Orthology more info
glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
glucose transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
insulin receptor binding	ISO Inferred from Sequence Orthology more info
substrate-specific transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
carbohydrate transport	TAS Traceable Author Statement more info	PubMed
carbohydrate utilization	ISO Inferred from Sequence Orthology more info
dehydroascorbic acid transport	IDA Inferred from Direct Assay more info	PubMed
dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
glucose transport	IDA Inferred from Direct Assay more info	PubMed
glucose transport	ISO Inferred from Sequence Orthology more info
glucose transport	TAS Traceable Author Statement more info	PubMed
hexose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
hexose transmembrane transport	TAS Traceable Author Statement more info	PubMed
transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
brush border	IDA Inferred from Direct Assay more info	PubMed
brush border	ISO Inferred from Sequence Orthology more info
brush border membrane	ISO Inferred from Sequence Orthology more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytosol	ISO Inferred from Sequence Orthology more info
endosome	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 2

Names: solute carrier family 2, facilitated glucose transporter member 2; liver-type glucose transporter; glucose transporter type 2, liver

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031197.2 → NP_112474.2 solute carrier family 2, facilitated glucose transporter member 2

Status: VALIDATED

Source sequence(s)

AI120520, AK005068, AK165430

Consensus CDS

CCDS50880.1

UniProtKB/Swiss-Prot

P14246

Related

ENSMUSP00000029240, OTTMUSP00000050835, ENSMUST00000029240, OTTMUST00000092113

Conserved Domains (2) summary

cd06174
Location:90 – 228
Blast Score: 156

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:14 – 498
Blast Score: 1118

Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000069.6 Reference GRCm38.p1 C57BL/6J

Range

28697903..28728361

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000025.1 Alternate Mm_Celera

Range

28651848..28682069

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01025064.1 (1391..24574)	None
genomic	AAHY01025065.1	None
genomic	AAHY01025066.1	None
genomic	AC121268.7 (17307..47660)	None
genomic	CH466530.1	EDL34941.1	mixed
		EDL34942.1	mixed
		EDL34943.1	mixed
genomic	HC890363.1	CBN59671.1
genomic	HC898028.1	CBN63423.1
genomic	HC902288.1	CBN65602.1
genomic	X78722.1	CAA55368.1
mRNA	AI120520.1	None	C57BL
mRNA	AK005068.1	BAB23792.1	C57BL/6J
mRNA	AK149532.1	None	C57BL/6J
mRNA	AK165430.1	BAE38184.1	C57BL/6J
mRNA	BC034675.1	AAH34675.1	FVB/N
mRNA	S77926.1	AAB20847.1
mRNA	X15684.1	CAA33719.1	C57BL/6
mRNA	X16986.1	CAA34855.1	BALB/c