Display Settings:

Format

Send to:

Choose Destination

EPHB3 EPH receptor B3 [ Homo sapiens (human) ]

Gene ID: 2049, updated on 26-Aug-2014
Official Symbol
EPHB3provided by HGNC
Official Full Name
EPH receptor B3provided by HGNC
Primary source
HGNC:3394
See related
Ensembl:ENSG00000182580; HPRD:03502; MIM:601839; Vega:OTTHUMG00000156710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ETK2; HEK2; TYRO6
Summary
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]
See EPHB3 in Epigenomics, MapViewer
Location:
3q27.1
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (184561799..184582408)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (184279587..184300196)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene chordin Neighboring gene transmembrane epididymal protein 1 pseudogene Neighboring gene uncharacterized LOC100505710 Neighboring gene melanoma antigen family F, 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
    EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
  • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHB forward signaling, organism-specific biosystem
    EPHB forward signaling
  • EPHB-mediated forward signaling, organism-specific biosystem (from REACTOME)
    EPHB-mediated forward signaling, organism-specific biosystemMultiple EPHB receptors contribute directly to dendritic spine development and morphogenesis. These are more broadly involved in post-synaptic development through activation of focal adhesion kinase ...
  • Ephrin signaling, organism-specific biosystem (from REACTOME)
    Ephrin signaling, organism-specific biosystemThe interaction between ephrin (EFN) ligands and EPH receptors results not only in forward signaling through the EPH receptor, but also in 'reverse' signaling through the EFN ligand itself. Reverse s...
  • EphrinB-EPHB pathway, organism-specific biosystem (from Pathway Interaction Database)
    EphrinB-EPHB pathway, organism-specific biosystem
    EphrinB-EPHB pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
axon guidance receptor activity IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
axonal fasciculation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell migration IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system projection neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
 
corpus callosum development ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
digestive tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
palate development ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of Cdc42 GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of Rac GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
thymus development ISS
Inferred from Sequence or Structural Similarity
more info
 
urogenital system development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
dendrite IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ephrin type-B receptor 3
Names
ephrin type-B receptor 3
EK2
EPH-like kinase 2
embryonic kinase 2
human embryo kinase 2
EPH-like tyrosine kinase 2
EPH-like tyrosine kinase-2
tyrosine-protein kinase TYRO6
NP_004434.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004443.3NP_004434.2  ephrin type-B receptor 3 precursor

    See proteins identical to NP_004434.2

    Status: REVIEWED

    Source sequence(s)
    BC052968, CB993133, X75208
    Consensus CDS
    CCDS3268.1
    UniProtKB/Swiss-Prot
    P54753
    Related
    ENSP00000332118, OTTHUMP00000210455, ENST00000330394, OTTHUMT00000345413
    Conserved Domains (9) summary
    cd05065
    Location:628896
    Blast Score: 1592
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09553
    Location:922990
    Blast Score: 368
    SAM_EPH-B3; SAM domain of EPH-B3 subfamily of tyrosine kinase receptors
    smart00454
    Location:922989
    Blast Score: 221
    SAM; Sterile alpha motif
    cd10478
    Location:39211
    Blast Score: 1047
    EphR_LBD_B3; Ligand Binding Domain of Ephrin type-B Receptor 3
    cd00063
    Location:473542
    Blast Score: 163
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00185
    Location:256336
    Blast Score: 106
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    pfam07699
    Location:284316
    Blast Score: 115
    GCC2_GCC3; GCC2 and GCC3
    pfam07714
    Location:633892
    Blast Score: 1068
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:559630
    Blast Score: 220
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    184561799..184582408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    181691476..181712092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    184243646..184264249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)