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    HIPK1 homeodomain interacting protein kinase 1 [ Homo sapiens ]

    Gene ID: 204851, updated on 11-May-2012
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    Summary

    Official Symbol
    HIPK1provided by HGNC
    Official Full Name
    homeodomain interacting protein kinase 1provided by HGNC
    Primary source
    HGNC:19006
    Locus tag
    RP4-786G8.2
    See related
    Ensembl:ENSG00000163349; HPRD:06418; MIM:608003; Vega:OTTHUMG00000011983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Myak; Nbak2; KIAA0630; MGC26642; MGC33446; MGC33548
    Summary
    The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1p13.2
    Sequence :
    Chromosome: 1; NC_000001.10 (114471996..114520491)
    See HIPK1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100287722 Neighboring gene adaptor-related protein complex 4, beta 1 subunit Neighboring gene DNA cross-link repair 1B Neighboring gene olfactomedin-like 3 Neighboring gene ribosomal protein L13a pseudogene 10

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779.
    4. HIPK1 interacts with c-Myb and modulates its activity through phosphorylation. Matre V, et al. Biochem Biophys Res Commun, 2009 Oct 9. PMID 19646965.
    5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.

    See all (16) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. c-Myb appears to be phosphorylated by HIPK1 in its negative regulatory domain as supported by both in vivo and in vitro data.
      Title: HIPK1 interacts with c-Myb and modulates its activity through phosphorylation.
    2. TNFalpha-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha-induced ASK1-JNK/p38 activation
      Title: Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q86Z02 Q9UER7 DAXX    HPRD  PubMed  
    Q86Z02 P09016 HOXD4    HPRD  PubMed  
    Q86Z02 P52952 NKX2-5    HPRD  PubMed  
    Q86Z02 Q01196 RUNX1    HPRD  PubMed  
    Q86Z02 P12757 SKIL    HPRD  PubMed  
    Q86Z02 Q8TAD8 SNIP1    HPRD  PubMed  
    Q86Z02 P04637 TP53    HPRD  PubMed  
    BioGRID:128490 BioGRID:107985 DAXX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:128490 BioGRID:109014 GLUL    BioGRID  PubMed Two-hybrid 
    BioGRID:128490 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:128490 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128490 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    definitive hemopoiesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    homeodomain-interacting protein kinase 1
    Names
    homeodomain-interacting protein kinase 1
    nuclear body-associated kinase 2
    nuclear body associated kinase 2b
    homeodomain interacting protein kinase 1-like protein
    NP_689909.2
    NP_852003.1
    NP_938009.1
    NP_938010.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152696.3 → NP_689909.2  homeodomain-interacting protein kinase 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a distinct 3' UTR and coding region, compared to variant 1. This results in a protein (isoform 2) which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB089957, BC033012
      Consensus CDS
      CCDS868.1
      UniProtKB/Swiss-Prot
      Q86Z02
      Related
      ENSP00000358572, OTTHUMP00000013764, ENST00000369559, OTTHUMT00000033128
      Conserved Domains (2) summary
      pfam00069
      Location:190 – 518
      Blast Score: 477
      Pkinase; Protein kinase domain
      cl09925
      Location:190 – 517
      Blast Score: 501
      PKc_like; Protein Kinases, catalytic domain

    2. NM_181358.2 → NP_852003.1  homeodomain-interacting protein kinase 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks one 5' coding exon, compared to variant 1. These differences result in the use of a downstream translation initiation site and a protein (isoform 4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA995033, AK302726, AL731797, BC033012, BC036057
      Consensus CDS
      CCDS869.1
      UniProtKB/TrEMBL
      B4DZ33
      UniProtKB/Swiss-Prot
      Q86Z02
      Related
      ENSP00000358566, OTTHUMP00000013768, ENST00000369553, OTTHUMT00000033134
      Conserved Domains (1) summary
      cl09925
      Location:47 – 128
      Blast Score: 125
      PKc_like; Protein Kinases, catalytic domain

    3. NM_198268.2 → NP_938009.1  homeodomain-interacting protein kinase 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA995033, AK302726, AL731797, BC033012
      Consensus CDS
      CCDS867.1
      UniProtKB/TrEMBL
      B4DZ33
      UniProtKB/Swiss-Prot
      Q86Z02
      Related
      ENSP00000409673, ENST00000443627
      Conserved Domains (2) summary
      pfam00069
      Location:190 – 518
      Blast Score: 481
      Pkinase; Protein kinase domain
      cl09925
      Location:190 – 517
      Blast Score: 502
      PKc_like; Protein Kinases, catalytic domain

    4. NM_198269.2 → NP_938010.1  homeodomain-interacting protein kinase 1 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks one 5' coding exon, compared to variant 1. These differences result in the use of a downstream translation initiation site and a protein (isoform 3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA995033, AK302726, AL731797, BC028408
      Consensus CDS
      CCDS41370.1
      UniProtKB/TrEMBL
      B4DZ33
      UniProtKB/Swiss-Prot
      Q86Z02
      Related
      ENSP00000340956, OTTHUMP00000218034, ENST00000340480, OTTHUMT00000033133
      Conserved Domains (1) summary
      cl09925
      Location:1 – 143
      Blast Score: 199
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      114471996..114520491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      112330056..112378556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL137856.24 (136459..143617) None
    genomic AL731797.9 CAI22792.1
      CAI22793.1
      CAI22794.1
      CAI22795.1
      CAI22796.1
    genomic CH471122.1 EAW56585.1
      EAW56586.1
      EAW56587.1
      EAW56588.1
      EAW56589.1
      EAW56590.1
      EAW56591.1
      EAW56592.1
      EAW56593.1
    mRNA AA995033.1 None
    mRNA AB014530.1 BAA31605.1
    mRNA AB089957.1 BAC57075.1
    mRNA AK122662.1 BAG53650.1
    mRNA AK302726.1 BAG63945.1
    mRNA AL833829.1 CAD38689.1
    mRNA BC028408.1 AAH28408.1
    mRNA BC033012.2 AAH33012.1
    mRNA BC033339.1 None
    mRNA BC036057.1 AAH36057.1
    mRNA BC052493.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SQL1 GenPept UniProtKB/TrEMBL:Q5SQL1
    Q5SQL3 GenPept UniProtKB/TrEMBL:Q5SQL3
    Q86Z02.1 GenPept UniProtKB/Swiss-Prot:Q86Z02
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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