Sin3a transcriptional regulator, SIN3A (yeast) [Mus musculus (house mouse)] - Gene

Summary

Go to the top of the page Help

Official Symbol: Sin3aprovided by MGI
Official Full Name: transcriptional regulator, SIN3A (yeast)provided by MGI
Primary source: MGI:107157
See related: Ensembl:ENSMUSG00000042557; Vega:OTTMUSG00000036738
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sin3; mSin3A; AW553200; mKIAA4126

Genomic context

Go to the top of the page Help

Location :: 9 B; 9 30.89 cM

Sequence :: Chromosome: 9; NC_000075.6 (57072040..57128368)

See Sin3a in Epigenomics, MapViewer

Chromosome 9 - NC_000075.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Within the male germline, Sin3a is required for the mitotic reentry of gonocytes, but is dispensable for the maintenance of differentiating spermatogonia and subsequent spermatogenic processes.
Title: Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia.
Sin3A-deleted testes exhibit a Sertoli-cell only phenotype, consistent with the absolute requirement for Sin3A in germ cells' development and/or viability.
Title: Chromatin associated Sin3A is essential for male germ cell lineage in the mouse.
Sin3 has an important role in the regulation of cell cycle kinetics of the myogenic progenitor cell population
Title: Sin3 interacts with Foxk1 and regulates myogenic progenitors.
ARID4B physically interacts with the breast cancer metastasis suppressor BRMS1, and we detected differential binding of the Arid4b alleles to mSIN3A and mSDS3
Title: Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis.
Results indicate that Sin3a protects the genomic integrity of pluripotent embryonic cells and governs their unusual cell cycle.
Title: Sin3a is essential for the genome integrity and viability of pluripotent cells.
Sin3a causes deacetylation of c-Myc protein to directly repress c-Myc activity.
Title: The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.
show using NMR that the mSin3A PAH3-SAP30 SID complex can bind to nucleic acids, hinting at a role for a nucleolar localization sequence in the SID alphaA helix in targeting the Rpd3L/Sin3L complex for silencing ribosomal RNA genes
Title: Structure of the 30-kDa Sin3-associated protein (SAP30) in complex with the mammalian Sin3A corepressor and its role in nucleic acid binding.
analysis indicates PSF within the PER complex recruits SIN3A, a scaffold for assembly of transcriptional inhibitory complexes, and the PER complex thereby rhythmically delivers histone deacetylases to the Per1 promoter, which repress Per1 transcription
Title: A molecular mechanism for circadian clock negative feedback.
Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation.
Title: Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation.
Results describe a novel transcriptional role for Sin3A and Sin3B proteins associated with maintenance of differentiated muscle cells.
Title: The mammalian Sin3 proteins are required for muscle development and sarcomere specification.

Submit: New GeneRIF Correction See all (20)

Alleles

Go to the top of the page Help

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (1) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
NP_035508.1	NP_035770.1	Trp53	BIND	PubMed	p53 interacts with mSin3a.
BioGRID:203256	BioGRID:197981	Add1	BioGRID	PubMed	Reconstituted Complex
BioGRID:203256	BioGRID:198145	Apex1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:220298	Arid1a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:114729	COPS2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:203256	BioGRID:198669	Cebpb	BioGRID	PubMed	Reconstituted Complex
BioGRID:203256	BioGRID:207545	Ddx20	BioGRID	PubMed	Reconstituted Complex
BioGRID:203256	BioGRID:108317	ELK1	BioGRID	PubMed	Reconstituted Complex
BioGRID:203256	BioGRID:199540	Etv6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:108997	GLI1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:108999	GLI3	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:203256	BioGRID:231518	Gatad2a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:217912	Gon4l	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:109314	HTT	BioGRID	PubMed	Reconstituted Complex
BioGRID:203256	BioGRID:241423	Hdac1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:200260	Hdac2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:115604	IKZF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:115904	KLF1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:203256	BioGRID:217610	Kdm5b	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:228800	Klf11	BioGRID	PubMed	Co-localization
BioGRID:203256	BioGRID:206125	Klf13	BioGRID	PubMed	Reconstituted Complex
BioGRID:203256	BioGRID:229554	L3mbtl2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:203256	BioGRID:110478	MNT	BioGRID	PubMed	Two-hybrid
BioGRID:203256	BioGRID:110259	MXD1	BioGRID	PubMed	Far Western; Reconstituted Complex
BioGRID:203256	BioGRID:201380	Mecp2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:201461	Mnt	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:215050	Nanog	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:203256	BioGRID:201752	Nfkb2	BioGRID	PubMed	Co-localization
BioGRID:203256	BioGRID:202111	Per1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:202112	Per2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:111860	RB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:203256	BioGRID:111910	REST	BioGRID	PubMed	Reconstituted Complex
BioGRID:203256	BioGRID:198519	Runx1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:203256	BioGRID:115573	SAP18	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex
BioGRID:203256	BioGRID:112319	SFPQ	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:203256	BioGRID:112389	SKIL	BioGRID	PubMed	Reconstituted Complex
BioGRID:203256	BioGRID:110263	SMAD3	BioGRID	PubMed	Reconstituted Complex
BioGRID:203256	BioGRID:112499	SNAI1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:112476	SNAI2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:130614	SNAI3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:203184	Sfpi1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:203256	BioGRID:214752	Sfpq	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:203220	Shh	BioGRID	PubMed	Phenotypic Suppression
BioGRID:203256	BioGRID:203257	Sin3b	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:201277	Smad4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:58618	Smr	BioGRID	PubMed	Two-hybrid
BioGRID:203256	BioGRID:203418	Sp3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:215053	Suds3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:204881	Sufu	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Enhancement
BioGRID:203256	BioGRID:112771	TBP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:203962	Tal1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203256	BioGRID:206599	Tet1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:203256	BioGRID:229496	Tet2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:203256	BioGRID:219895	Tfcp2l1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:203256	BioGRID:204323	Trp53	BioGRID	PubMed	Two-hybrid
BioGRID:203256	BioGRID:204624	Yy1	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

Go to the top of the page Help

Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
Factors involved in megakaryocyte development and platelet production, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hedgehog Signaling Pathway, organism-specific biosystem (from WikiPathways)
Hedgehog Signaling Pathway, organism-specific biosystemThe Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, pre...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Huntington's disease, organism-specific biosystem (from KEGG)
Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Huntington's disease, conserved biosystem (from KEGG)
Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PluriNetWork, organism-specific biosystem (from WikiPathways)
PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer
estrogen signalling, organism-specific biosystem (from WikiPathways)
estrogen signalling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17&amp;#x3b2;-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...

General gene information

Go to the top of the page Help

Markers

Sin3a (e-PCR), detects polymorphism
- UniSTS:472919

Sin3a (e-PCR), detects polymorphism
- UniSTS:472920

AW553200 (e-PCR)
- UniSTS:163460

Homology

Homologs of the Sin3a gene: The Sin3a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and A.thaliana.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II activating transcription factor binding	ISO Inferred from Sequence Orthology more info
RNA polymerase II repressing transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
RNA polymerase II transcription corepressor activity	IGI Inferred from Genetic Interaction more info	PubMed
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	ISO Inferred from Sequence Orthology more info
protein deacetylase activity	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
activation of innate immune response	ISO Inferred from Sequence Orthology more info
aging	ISO Inferred from Sequence Orthology more info
cellular protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of histone H3-K27 acetylation	ISO Inferred from Sequence Orthology more info
negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
negative regulation of transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of chromatin silencing	ISO Inferred from Sequence Orthology more info
positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
protein deacetylation	ISO Inferred from Sequence Orthology more info
regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
response to methylglyoxal	IDA Inferred from Direct Assay more info	PubMed
response to organic nitrogen	ISO Inferred from Sequence Orthology more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Sin3 complex	ISO Inferred from Sequence Orthology more info
chromatin	ISO Inferred from Sequence Orthology more info
kinetochore	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
protein complex	ISO Inferred from Sequence Orthology more info
transcription factor complex	IPI Inferred from Physical Interaction more info	PubMed
transcriptional repressor complex	IDA Inferred from Direct Assay more info	PubMed
transcriptional repressor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: paired amphipathic helix protein Sin3a

Names: paired amphipathic helix protein Sin3a; transcriptional corepressor Sin3a; histone deacetylase complex subunit Sin3a; transcriptional regulator, SIN3 yeast homolog A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110350.1 → NP_001103820.1 paired amphipathic helix protein Sin3a isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a segment in the 5' UTR and uses a different splice site in the 3' CDS, compared to variant 1. The resulting protein (isoform 2) is longer than isoform 1.

Source sequence(s)

AC132406, AK220292, BC078454

Consensus CDS

CCDS52805.1

UniProtKB/Swiss-Prot

Q60520

Related

ENSMUSP00000130221, OTTMUSP00000052360, ENSMUST00000168177, OTTMUST00000094224

Conserved Domains (3) summary

COG5602
Location:8 – 823
Blast Score: 1130

SIN3; Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]

pfam08295
Location:551 – 651
Blast Score: 457

Sin3_corepress; Sin3 family co-repressor

pfam02671
Location:141 – 187
Blast Score: 197

PAH; Paired amphipathic helix repeat
NM_001110351.1 → NP_001103821.1 paired amphipathic helix protein Sin3a isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein.

Source sequence(s)

AK032209, BC078454, BY020498

Consensus CDS

CCDS23216.1

UniProtKB/Swiss-Prot

Q60520

Related

ENSMUSP00000130641, OTTMUSP00000052361, ENSMUST00000167715, OTTMUST00000094225

Conserved Domains (3) summary

COG5602
Location:8 – 823
Blast Score: 1128

SIN3; Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]

pfam08295
Location:551 – 651
Blast Score: 457

Sin3_corepress; Sin3 family co-repressor

pfam02671
Location:141 – 187
Blast Score: 197

PAH; Paired amphipathic helix repeat
NM_011378.2 → NP_035508.2 paired amphipathic helix protein Sin3a isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 3 encode the same protein.

Source sequence(s)

AC132406, AK032209, AK220292, BC078454, L38620

Consensus CDS

CCDS23216.1

UniProtKB/Swiss-Prot

Q60520

Related

ENSMUSP00000126601, OTTMUSP00000052359, ENSMUST00000168678, OTTMUST00000094223

Conserved Domains (3) summary

COG5602
Location:8 – 823
Blast Score: 1128

SIN3; Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]

pfam08295
Location:551 – 651
Blast Score: 457

Sin3_corepress; Sin3 family co-repressor

pfam02671
Location:141 – 187
Blast Score: 197

PAH; Paired amphipathic helix repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000075.6 Reference GRCm38.p1 C57BL/6J

Range

57072040..57128368

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000031.1 Alternate Mm_Celera

Range

54295792..54352077

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01078381.1 (39380..95665)	None
genomic	AC132406.4 (38906..90682)	None
genomic	CH466522.1	EDL25883.1	mixed
		EDL25884.1	mixed
		EDL25885.1	mixed
mRNA	AK032209.1	None	C57BL/6J
mRNA	AK037537.1	None	C57BL/6J
mRNA	AK136347.1	None	C57BL/6J
mRNA	AK136972.1	BAE23192.1	C57BL/6J
mRNA	AK211749.1	None
mRNA	AK220292.1	BAD90217.1
mRNA	BC052716.1	AAH52716.1	C57BL/6
mRNA	BC053385.1	AAH53385.1	C57BL/6J
mRNA	BC078454.1	None	C57BL/6
mRNA	BY020498.1	None
mRNA	L36831.1	AAB01610.1	129
mRNA	L38620.2	AAA69773.2
mRNA	L38621.2	AAA69772.2
mRNA	U22394.1	AAA89119.1	ICR