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Sim1 single-minded homolog 1 (Drosophila) [ Mus musculus (house mouse) ]

Gene ID: 20464, updated on 28-May-2016
Official Symbol
Sim1provided by MGI
Official Full Name
single-minded homolog 1 (Drosophila)provided by MGI
Primary source
MGI:MGI:98306
See related
Ensembl:ENSMUSG00000019913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mSIM1; bHLHe14
Orthologs
Location:
10 B3; 10 24.87 cM
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (50894673..50989156)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (50615457..50708958)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene activating signal cointegrator 1 complex subunit 3 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene uncharacterized LOC105245152 Neighboring gene predicted gene, 35917 Neighboring gene ribosomal protein L7A pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor activity, sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
single-minded homolog 1
Names
single-minded 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011376.3NP_035506.2  single-minded homolog 1

    See identical proteins and their annotated locations for NP_035506.2

    Status: VALIDATED

    Source sequence(s)
    AC152948, AC153951
    Consensus CDS
    CCDS48556.1
    UniProtKB/Swiss-Prot
    Q61045
    Related
    ENSMUSP00000020071, ENSMUST00000020071
    Conserved Domains (5) summary
    cd00083
    Location:252
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:229328
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:79158
    PAS; PAS fold
    pfam06621
    Location:359669
    SIM_C; Single-minded protein C-terminus
    pfam08447
    Location:243329
    PAS_3; PAS fold

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    50894673..50989156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512626.2XP_006512689.1  

    Conserved Domains (5) summary
    cd00083
    Location:252
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:265364
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:115194
    PAS; PAS fold
    pfam06621
    Location:395705
    SIM_C; Single-minded protein C-terminus
    pfam08447
    Location:279365
    PAS_3; PAS fold
  2. XM_011243148.1XP_011241450.1  

    See identical proteins and their annotated locations for XP_011241450.1

    Conserved Domains (4) summary
    cd00083
    Location:252
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:265364
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:115194
    PAS; PAS fold
    pfam08447
    Location:279365
    PAS_3; PAS fold
  3. XM_006512632.2XP_006512695.1  

    See identical proteins and their annotated locations for XP_006512695.1

    Conserved Domains (4) summary
    cd00083
    Location:252
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:265364
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:115194
    PAS; PAS fold
    pfam08447
    Location:279365
    PAS_3; PAS fold
  4. XM_006512627.2XP_006512690.1  

    See identical proteins and their annotated locations for XP_006512690.1

    UniProtKB/Swiss-Prot
    Q61045
    Conserved Domains (5) summary
    cd00083
    Location:252
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:229328
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:79158
    PAS; PAS fold
    pfam06621
    Location:359669
    SIM_C; Single-minded protein C-terminus
    pfam08447
    Location:243329
    PAS_3; PAS fold
  5. XM_006512629.2XP_006512692.1  

    See identical proteins and their annotated locations for XP_006512692.1

    Conserved Domains (3) summary
    cd00130
    Location:128227
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam06621
    Location:258568
    SIM_C; Single-minded protein C-terminus
    pfam08447
    Location:142228
    PAS_3; PAS fold
  6. XM_006512628.2XP_006512691.1  

    See identical proteins and their annotated locations for XP_006512691.1

    Conserved Domains (3) summary
    cd00130
    Location:128227
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam06621
    Location:258568
    SIM_C; Single-minded protein C-terminus
    pfam08447
    Location:142228
    PAS_3; PAS fold
  7. XM_006512630.1XP_006512693.1  

    Conserved Domains (3) summary
    cd00130
    Location:94193
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam06621
    Location:224534
    SIM_C; Single-minded protein C-terminus
    pfam08447
    Location:108194
    PAS_3; PAS fold
  8. XM_006512631.1XP_006512694.1  

    Conserved Domains (3) summary
    cd00130
    Location:32131
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam06621
    Location:162472
    SIM_C; Single-minded protein C-terminus
    pfam08447
    Location:46132
    PAS_3; PAS fold

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    51744683..51838475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)