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Sgpl1 sphingosine phosphate lyase 1 [ Mus musculus (house mouse) ]

Gene ID: 20397, updated on 28-May-2016
Official Symbol
Sgpl1provided by MGI
Official Full Name
sphingosine phosphate lyase 1provided by MGI
Primary source
MGI:MGI:1261415
See related
Ensembl:ENSMUSG00000020097 Vega:OTTMUSG00000031946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spl; S1PL; AI428538; D10Xrf456
Orthologs
Location:
10 B4; 10 32.14 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (61098642..61147686, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (60561390..60610413, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene 20611 Neighboring gene pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 Neighboring gene thymus, brain and testes associated Neighboring gene a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 Neighboring gene predicted gene, 29861

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
sphinganine-1-phosphate aldolase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Leydig cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
androgen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
 
estrogen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
face morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
female gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
luteinization IMP
Inferred from Mutant Phenotype
more info
PubMed 
nitrogen compound metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
sphingolipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
sphingosine-1-phosphate lyase 1
Names
SP-lyase 1
SPL 1
sphingosine-1-phosphate aldolase
NP_033189.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316673.1NP_001303602.1  sphingosine-1-phosphate lyase 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC123530, AI428538, AK049342, BB854743
    UniProtKB/Swiss-Prot
    Q8R0X7
    Conserved Domains (1) summary
    cd06450
    Location:146507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  2. NM_001316674.1NP_001303603.1  sphingosine-1-phosphate lyase 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC123530, AI428538, AK036747, BB854743, CD554088
    UniProtKB/Swiss-Prot
    Q8R0X7
    Conserved Domains (1) summary
    cd06450
    Location:146507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  3. NM_009163.4NP_033189.2  sphingosine-1-phosphate lyase 1

    See identical proteins and their annotated locations for NP_033189.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC123530, AI428538, AK036747, BB620054, BB854743
    Consensus CDS
    CCDS35914.1
    UniProtKB/Swiss-Prot
    Q8R0X7
    Related
    ENSMUSP00000112975, OTTMUSP00000042253, ENSMUST00000122259, OTTMUST00000079254
    Conserved Domains (1) summary
    cd06450
    Location:146507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    61098642..61147686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513402.2XP_006513465.1  

    Related
    ENSMUSP00000090155, OTTMUSP00000042252, ENSMUST00000092498, OTTMUST00000079253
    Conserved Domains (1) summary
    cd06450
    Location:146507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  2. XM_006513403.1XP_006513466.1  

    Conserved Domains (1) summary
    cd06450
    Location:146507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    62199269..62248215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)