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    NRK Nik related kinase [ Homo sapiens ]

    Gene ID: 203447, updated on 11-May-2012
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    Summary

    Official Symbol
    NRKprovided by HGNC
    Official Full Name
    Nik related kinaseprovided by HGNC
    Primary source
    HGNC:25391
    Locus tag
    RP1-82J11.1
    See related
    Ensembl:ENSG00000123572; HPRD:14841; MIM:300791; Vega:OTTHUMG00000022143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NESK; FLJ16788; MGC131849; DKFZp686A17109
    Summary
    The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]
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    Genomic context

    Location :
    Xq22.3
    Sequence :
    Chromosome: X; NC_000023.10 (105066536..105202602)
    See NRK in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein-like 2 Neighboring gene testis expressed 13A Neighboring gene potassium channel tetramerisation domain containing 9 pseudogene 2 Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 pseudogene Neighboring gene serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901.
    2. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651.
    3. From ORFeome to biology: a functional genomics pipeline. Wiemann S, et al. Genome Res, 2004 Oct. PMID 15489336.
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q7Z2Y5 P23528 CFL1    HPRD  PubMed  
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    small GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    nik-related protein kinase
    Names
    nik-related protein kinase
    NP_940867.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021425.1 RefSeqGene

      Range
      5001..141067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_198465.2 → NP_940867.2  nik-related protein kinase

      Status: REVIEWED

      Source sequence(s)
      BX538345, Z68339, Z69734, Z83850
      UniProtKB/Swiss-Prot
      Q7Z2Y5
      Related
      ENSP00000434830, OTTHUMP00000043367, ENST00000243300, OTTHUMT00000106480
      Conserved Domains (3) summary
      cd06608
      Location:18 – 313
      Blast Score: 1237
      STKc_myosinIII_like; Catalytic domain of Class III myosin-like Protein Serine/Threonine Kinases
      smart00220
      Location:25 – 313
      Blast Score: 633
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02434
      Location:1213 – 1549
      Blast Score: 323
      CNH; CNH domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      105066536..105202602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      94691867..94829421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic CH471120.2 EAX02749.1
      EAX02750.1
      EAX02751.1
    genomic Z68339.2 (104..11828) None
    genomic Z69734.2 (104..23605) None
    genomic Z70274.1 None
    genomic Z83850.1 (101..49116) None
    genomic Z97356.1 (102..21847) None
    mRNA AK131549.1 BAD18683.1
    mRNA AK293500.1 BAH11523.1
    mRNA AK300377.1 BAH13273.1
    mRNA BC108702.1 AAI08703.1
    mRNA BX538345.1 CAD98108.1
    other-genetic AM392900.1 CAL37778.1
    other-genetic AM393343.1 CAL38221.1
    other-genetic BC172241.1 AAI72241.1
    other-genetic BC172556.1 AAI72556.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z2Y5.2 GenPept UniProtKB/Swiss-Prot:Q7Z2Y5
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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