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    EP300 E1A binding protein p300 [ Homo sapiens (human) ]

    Gene ID: 2033, updated on 16-Jun-2013
    Official Symbol
    EP300provided by HGNC
    Official Full Name
    E1A binding protein p300provided by HGNC
    Primary source
    HGNC:3373
    Locus tag
    RP1-85F18.1
    See related
    Ensembl:ENSG00000100393; HPRD:04078; MIM:602700; Vega:OTTHUMG00000150937
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p300; KAT3B; RSTS2
    Summary
    This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
    Location :
    22q13.2
    Sequence :
    Chromosome: 22; NC_000022.10 (41488614..41576081)
    See EP300 in Epigenomics, MapViewer

    Chromosome 22 - NC_000022.10Genomic Context describing neighboring genes Neighboring gene actin, gamma 2, smooth muscle, enteric pseudogene Neighboring gene microRNA 1281 Neighboring gene uncharacterized LOC646927 Neighboring gene uncharacterized LOC100506544 Neighboring gene l(3)mbt-like 2 (Drosophila)

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. cAMP signalling decreases p300 protein levels by promoting its ubiquitin/proteasome dependent degradation via Epac and p38 MAPK in lung cancer cells. Jeong MJ, et al. FEBS Lett, 2013 May 2. PMID 23523631.
    2. P300 regulates the human RLIP76 promoter activity and gene expression. Sehrawat A, et al. Biochem Pharmacol, 2013 Apr 15. PMID 23419874.
    3. Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. Steunou AL, et al. Mol Cell Proteomics, 2013 Mar. PMID 23275444.
    4. BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300. Liu Y, et al. Cancer Res, 2013 Feb 15. PMID 23269275.
    5. miR-150 regulates high glucose-induced cardiomyocyte hypertrophy by targeting the transcriptional co-activator p300. Duan Y, et al. Exp Cell Res, 2013 Feb 1. PMID 23211718.

    See all (759) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. p300 associates with the RLIP76 promoter via an overlapping cMYB and cETS binding site and regulates RLIP76 promoter activity and its expression.
      Title: P300 regulates the human RLIP76 promoter activity and gene expression.
    2. the intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation
      Title: An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation.
    3. We present the first evidence that the portion of E2A proteins found within the oncogenic fusion protein E2A-PBX1 and including the transcriptional activation domains can enhance the HAT activity of CBP/p300
      Title: E2A proteins enhance the histone acetyltransferase activity of the transcriptional co-activators CBP and p300.
    4. our findings show that the E2A proteins are acetylated at specific residues as a consequence of lysine acetyltranferases(CBP, p300 and PCAF ) recruitment
      Title: Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation.
    5. Data indicate that mutation of E3 ligase motif not only abolishes BRMS1-induced p300 polyubiquitination and degradation, but importantly, dramatically reduces the metastasis suppressor function of BRMS1.
      Title: BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300.
    6. Evaluated the influence of gene variant A>G rs20551 in EP300 in donor and/or recipient on clinical results after HLA-identical sibling allo-SCT.
      Title: A constitutional variant in the transcription factor EP300 strongly influences the clinical outcome of patients submitted to allo-SCT.
    7. A novel upstream role for miR-150 in p300-mediated cardiomyocyte hypertrophy.
      Title: miR-150 regulates high glucose-induced cardiomyocyte hypertrophy by targeting the transcriptional co-activator p300.
    8. GR and p300 are involved in the induction of H6PD by cortisol in human amnion fibroblasts
      Title: Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts.
    9. studies suggest that the HPV16-E7 and Ad5-E1A viral oncoproteins bind to the same p300 CH1 domain to disrupt p300 function by distinct mechanisms.
      Title: Different regions of the HPV-E7 and Ad-E1A viral oncoproteins bind competitively but through distinct mechanisms to the CH1 transactivation domain of p300.
    10. variants of the transcriptional coactivator genes (EP300 and PCAF) may influence Hepatocellular carcinoma risk in populations with low mutations or chromosomal instability rates.
      Title: Associations of genetic variants in the transcriptional coactivators EP300 and PCAF with hepatocellular carcinoma.
    Submit: New GeneRIF Correction See all (206)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Rubinstein-Taybi syndrome

    Summary from GeneReviews: Rubinstein-Taybi Syndrome Go to GeneReviews

    Disease Characteristics
    Rubinstein-Taybi syndrome (RSTS) is characterized by distinctive facial features, broad and often angulated thumbs and great toes, short stature, and moderate to severe intellectual disability. The characteristic craniofacial features are downslanting palpebral fissures, columella extending below the nares, highly arched palate, grimacing smile, and talon cusps. Prenatal growth is often normal; however, height, weight, and head circumference percentiles rapidly drop in the first few months of life. Obesity may occur in childhood or adolescence. IQ scores range from 25 to 79; average IQ is between 36 and 51. Other variable findings are coloboma, cataract, congenital heart defects, renal abnormalities, and cryptorchidism.
    Diagnosis Testing
    The diagnosis of RSTS is primarily based on clinical features. Chromosome abnormalities are occasionally observed on routine cytogenetic testing. CREBBP and EP300 are the only genes currently known to be associated with RSTS. FISH analysis of CREBBP detects microdeletions in approximately 10% of individuals with RSTS. Sequence analysis detects CREBBP mutations in another 30%-50% of affected individuals. Mutations in EP300 are identified in approximately 3% of individuals with RSTS.
    Genetic Counseling
    RSTS is inherited in an autosomal dominant manner. RSTS typically occurs as the result of a de novo mutation in the family; most individuals represent simplex cases (i.e., the only affected member in a family). In most instances, the parents of an individual with RSTS are not affected. When the parents are clinically unaffected, the empiric recurrence risk for sibs is approximately 0.1%. Individuals with RSTS rarely reproduce. The theoretical risk to offspring is 50%. Prenatal testing for pregnancies at increased risk is possible if the disease-causing mutation or deletion in the family is known.
    References

    Rubinstein-Taybi syndrome 2

    Summary from GeneReviews: Rubinstein-Taybi Syndrome Go to GeneReviews

    Disease Characteristics
    Rubinstein-Taybi syndrome (RSTS) is characterized by distinctive facial features, broad and often angulated thumbs and great toes, short stature, and moderate to severe intellectual disability. The characteristic craniofacial features are downslanting palpebral fissures, columella extending below the nares, highly arched palate, grimacing smile, and talon cusps. Prenatal growth is often normal; however, height, weight, and head circumference percentiles rapidly drop in the first few months of life. Obesity may occur in childhood or adolescence. IQ scores range from 25 to 79; average IQ is between 36 and 51. Other variable findings are coloboma, cataract, congenital heart defects, renal abnormalities, and cryptorchidism.
    Diagnosis Testing
    The diagnosis of RSTS is primarily based on clinical features. Chromosome abnormalities are occasionally observed on routine cytogenetic testing. CREBBP and EP300 are the only genes currently known to be associated with RSTS. FISH analysis of CREBBP detects microdeletions in approximately 10% of individuals with RSTS. Sequence analysis detects CREBBP mutations in another 30%-50% of affected individuals. Mutations in EP300 are identified in approximately 3% of individuals with RSTS.
    Genetic Counseling
    RSTS is inherited in an autosomal dominant manner. RSTS typically occurs as the result of a de novo mutation in the family; most individuals represent simplex cases (i.e., the only affected member in a family). In most instances, the parents of an individual with RSTS are not affected. When the parents are clinically unaffected, the empiric recurrence risk for sibs is approximately 0.1%. Individuals with RSTS rarely reproduce. The theoretical risk to offspring is 50%. Prenatal testing for pregnancies at increased risk is possible if the disease-causing mutation or deletion in the family is known.
    References
    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun PubMed
    env HIV-1 gp120-induced apoptosis in human proximal renal tubular cells is significantly enhanced by p300, and Smad7 and an anti-TGF-beta antibody inhibit this effect of p300 PubMed
    Tat, p14 tat HIV-1 Tat, NAP-1, and p300 synergistically activate HIV-1 transcription PubMed
    tat Tat stimulates NF-kappaB-inducing kinase IKKalpha translocation from the cytoplasm to the nucleus in monocytes, which leads to IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14) PubMed
    tat HIV-1 Tat-induced upregulation of p300 occurs at the transcriptional level through the cis-acting elements of early growth response 1 (egr-1) within its promoter PubMed
    tat HIV-1 Tat-mediated upregulation of adenovirus E1a-associated 300 kDa protein p300 regulates increased GFAP expression in astrocytes PubMed
    tat Acetylation of HIV-1 Tat by p300 at Lys50 regulates Tat binding to cyclin T1 and HIV-1 TAR RNA, as well as Tat-mediated transactivation of the HIV-1 LTR promoter, by allowing Tat to dissociate from TAR RNA PubMed
    tat HIV-1 Tat interaction with p300 increases the histone acetyl transferase (HAT) activity of p300 on histone H4, indicating Tat modulates HAT activity of co-activators to derepress the HIV-1 chromatin structure and aid in activated transcription PubMed
    tat HIV-1 Tat interaction with p300 and other histone acetyl transferases is preferentially important for Tat-mediated transactivation of integrated, but not unintegrated, HIV-1 LTR promoter PubMed
    tat HIV-1 Tat forms a ternary complex with p300 and P/CAF PubMed
    tat HIV-1 Tat is acetylated by p300 on Lys50 and Lys51 PubMed
    tat Binding of HIV-1 Tat to p300 induces a conformational change in the CBP/p300 complex such that it can acquire and bind better to basal transcription factors, indicating Tat helps CBP/p300 recruit new partners to the transcription machinery PubMed
    tat HIV-1 Tat recruits CBP/p300 to the chromosomally integrated HIV-1 LTR promoter PubMed
    tat Acetylation of the p50 subunit of NFkappaB by CBP/p300 is regulated by HIV-1 Tat PubMed
    tat INI-1 and BRG-1 synergize with the p300 acetyltransferase to activate the HIV promoter; this synergism depends on the acetyltransferase activity of p300 and on HIV-1 Tat amino acids Lys(50) and Lys(51), suggesting a regulation of Tat by these proteins PubMed
    tat HIV-1 Tat binds to the minimal histone acetyltransferase domain (amino acids 1253-1710) and E1a binding domain (amino acids 1542-1710) of p300, an effect mediated by the basic domain (amino acids 48-57) of Tat PubMed
    tat HIV-1 Tat induces the polyubiquitination and degradation of Tip60 through p300/CBP-associated E4-type ubiquitin-ligase activity, which results in a dramatic impairment of the Tip60-dependent apoptotic cell response to DNA damage PubMed
    Vpr, p15 vpr HIV-1 Vpr and p300/HAT colocalizes with CENP-A and CENP-H proteins in the centromere and arm region of chromosome PubMed
    vpr HIV-1 Vpr actively recruits p300/HAT to a range of chromatine regions including the centromere, resulting in the displacement of HP1-alpha PubMed
    vpr Data suggests that HIV-1 Vpr, Rel A, and p300 act in concert to activate HIV transcription PubMed
    vpr Transcription Factor IIH (TFIIH) and p300 act cooperatively to enhance Vpr effects on glucocorticoid receptor transactivation PubMed
    vpr The C-terminus of HIV-1 Vpr (amino acids 64-84) mediates the binding of Vpr to p300 (amino acids 2045-2191) PubMed
    vpr HIV-1 Vpr transactivation of HIV transcription and of the glucocorticoid receptor pathway is mediated by direct binding to the p300 co-activator PubMed
    vpr Adenovirus E1A protein represses activation by Vpr by competing for binding to p300, suggesting that p300 is required for activation of HIV transcription by Vpr PubMed
    pol gag-pol The interaction between HIV-1 IN and KAP1 is highly favored by HAT/p300-mediated IN acetylation PubMed
    gag-pol HAT/p300 acetylates lysine's 264, 266, and 273 of HIV-1 IN PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    AL080243.21     BIND  PubMed p300 promoter interacts with Egr1-p300 complex. 
    NP_001420.1 NP_009225.1 BRCA1    BIND  PubMed p300 interacts with BRCA1. 
    NP_001420.1 NP_040910.1 E1A    BIND  PubMed E1A interacts with p300. This interaction was modeled on a demonstrated interaction between p300 from an unspecified source and E1A from an unspecified adenovirus. 
    NP_001420.1 AJ243425.1 EGR1    BIND  PubMed p300 interacts with Egr1 promoter. 
    NP_001420.1 NP_001955.1 EGR1    BIND  PubMed p300 interacts with Egr1. 
    NP_001420.1 NP_057246.2 ING4    BIND  PubMed p300 interacts with p29ING4. 
    NP_001420.1 NP_115705.2 ING5    BIND  PubMed p300 interacts with p28ING5. 
    NP_001420.1 NP_005351.2 MAF    BIND  PubMed p300 interacts with c-Maf. This interaction was modeled on a demonstrated interaction between c-Maf from an unspecified source and human p300. 
    NP_001420.1 NP_002754.2 PROX1    BIND  PubMed p300 interacts with Prox-1. This interaction was modeled on a demonstrated interaction between Prox-1 from an unspecified source and human p300. 
    NP_001420.1 NP_005044.1 RAD23A    BIND  PubMed hHR23A interacts with p300. This interaction was modelled on a demonstrated interaction between hHR23A from human and p300 from an unspecified species. 
    NP_001420.1 NP_005893.1 SMAD3    BIND  PubMed Smad3 interacts with p300. This interaction was modeled on a demonstrated interaction between Smad3 and p300 from an unspecified sources. 
    NP_001420.1 NP_005410.1 STAT2    BIND  PubMed Stat2 interacts with p300. 
    NP_001420.1 NT_086913.1 TFF1    BIND  PubMed p300 interacts with pS2. 
    NP_001420.1 NP_000537.2 TP53    BIND  PubMed p300 interacts with p53. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human p53. 
    NP_001420.1 NP_005418.1 TP73    BIND  PubMed p73-alpha interacts with p300.This interaction was modeled on a demonstrated interaction between human p73-alpha and p300 from an unspecified species. 
    NP_001420.1 NP_057853.1 tat    BIND  PubMed Tat interacts with p300. 
    NP_001420.2 NC_000011.8 BIRC3    BIND  PubMed The cIAP-2 promoter interacts with p300. 
    NP_001420.2 NP_954592.1 CARM1    BIND  PubMed CARM1 interacts with p300. 
    NP_001420.2 NP_001319.1 CTBP1    BIND  PubMed CTBP1 interacts with EP300 (p300) 
    NP_001420.2 NC_000004.9 CXCL10    BIND  PubMed p300 interacts with promoter IP-10. 
    NP_001420.2 NP_001420.2 EP300    BIND  PubMed EP300 (p300) autoacetylates. This interaction was modeled on a demonstrated interaction using EP300 from an unspecified species. 
    NP_001420.2 NP_000116.1 ESR1    BIND  PubMed EP300 (p300) acetylates ESR1 (ER-alpha). This interaction was modeled on a demonstrated interaction between EP300 from an unspecified species and ESR1 from an unspecified species. 
    NP_001420.2 NP_001505.1 GTF2B    BIND  PubMed p300 interacts with TFIIB. This interaction is modelled on a demonstrated interaction between human p300 and TFIIB from an unspecified species. 
    NP_001420.2 NP_002098.1 H3F3A    BIND  PubMed EP300 (p300) interacts with H3F3A (histone 3). 
    NP_001420.2 BAC02464.1 HCVgp1    BIND  PubMed HCV core protein interacts with p300. 
    NP_001420.2 NP_778224.1 HIST4H4    BIND  PubMed EP300 (p300) interacts with HIST4H4 (histone 4) 
    NP_001420.2 NC_000004.9 IL8    BIND  PubMed The IL-8 promoter interacts with p300. 
    NP_001420.2 NP_055572.1 MAML1    BIND  PubMed p300 interacts with MAML1. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human MAML1. 
    NP_001420.2 NP_002425.1 MPG    BIND  PubMed EP300 (p300) acetylates MPG. This interaction was modeled on a demonstrated interaction between EP300 from an unspecified species and MPG from an unspecified species. 
    NP_001420.2 NP_005366.2 MYB    BIND  PubMed c-Myb interacts with p300. 
    NP_001420.2 NP_002469.2 MYOD1    BIND  PubMed p300 interacts with MyoD. This interaction is modelled on a demonstrated interaction between human and mouse p300 and MyoD from mouse and an unspecified species. 
    NP_001420.2 NP_671766.1 NCOA1    BIND  PubMed NCOA1 (SRC-1) interacts with EP300 (p300). 
    NP_001420.2 NP_006531.1 NCOA2    BIND  PubMed GRIP1 interacts with p300. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human p300. 
    NP_001420.2 NP_036517.1 NUPR1    BIND  PubMed p8 interacts with and is acetylated by p300. 
    NP_001420.2 NP_005595.2 POU3F2    BIND  PubMed Brn-2 interacts with p300. 
    NP_001420.2 NP_068810.2 RELA    BIND  PubMed p300 interacts with p65. 
    NP_001420.2 NP_068810.2 RELA    BIND  PubMed p300 interacts with p65. 
    NP_001420.2 NP_005892.1 SMAD2    BIND  PubMed p300 interacts with Smad2. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human Smad2. 
    NP_001420.2 NP_005893.1 SMAD3    BIND  PubMed SMAD3 interacts with EP300 (p300). 
    NP_001420.2 SMAD4    BIND  PubMed p300 interacts with Smad4 fragment. p300 interacting with full-length Smad4 could not be demonstrated in vitro. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human Smad4 fragment. 
    NP_001420.2 NP_644671.1 STAT1    BIND  PubMed Stat1-beta interacts with p300. This interaction is modelled on a demonstrated interaction between human Stat1-beta and p300 from an unspecified species. 
    NP_001420.2 NP_644805.1 STAT3    BIND  PubMed Stat3 interacts with p300. 
    NP_001420.2 NP_996743.1 TACC2    BIND  PubMed TACC2 interacts with p300. 
    NP_001420.2 NP_003185.1 TBP    BIND  PubMed p300 interacts with TBP. 
    NP_001420.2 NP_003196.1 TCF12    BIND  PubMed HEBb interacts with p300. 
    NP_001420.2 NP_996919.1 TCF12    BIND  PubMed HEBa interacts with p300. This interaction was modeled on a demonstrated interaction between HEBb and p300. 
    NP_001420.2 NP_000537.2 TP53    BIND  PubMed p300 interacts with and acetylates p53. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human p53. 
    NP_001420.2 NP_000537.2 TP53    BIND  PubMed p300 interacts with p53 
    NP_001420.2 NT_033899.7 TP53AIP1    BIND  PubMed p300 interacts with p53AIP1 promoter. 
    NP_001420.2 NP_044282.1 bel-1    BIND  PubMed p300 interacts with Bel1. 
    NP_001420.2 AAR06173.1     BIND  PubMed HCV core interacts with p300. 
    NP_001420.2 U24170.1     BIND  PubMed p300 interacts with p21. 
    NP_001420.2     BIND  PubMed The Survivin promoter/TCF/beta-catenin complex interacts with p300. 
    NP_001420.2     BIND  PubMed Stat1-alpha-Stat1-alpha interacts with p300. This interaction was modelled on a demonstrated interaction between human Stat1-alpha-Stat1-alpha and p300 from an unspecified species. 
    Q09472 P00519 ABL1    HPRD  PubMed  
    Q09472 P62736 ACTA2    HPRD  PubMed  
    Q09472 P35869 AHR    HPRD  PubMed  
    Q09472 P31749 AKT1    HPRD  PubMed  
    Q09472 Q15699 ALX1    HPRD  PubMed  
    Q09472 P27695 APEX1    HPRD  PubMed  
    Q09472 P10275 AR    HPRD  PubMed  
    Q09472 P27540 ARNT    HPRD  PubMed  
    Q09472 P50553 ASCL1    HPRD  PubMed  
    Q09472 P46379 BAG6    HPRD  PubMed  
    Q09472 P41182 BCL6    HPRD  PubMed  
    Q09472 P38398 BRCA1    HPRD  PubMed  
    Q09472 Calcium binding and coiled-coil domain 1 CALCOCO1    HPRD  PubMed  
    Q09472 Q86X55 CARM1    HPRD  PubMed  
    Q09472 P24385 CCND1    HPRD  PubMed  
    Q09472 P24941 CDK2    HPRD  PubMed  
    Q09472 Q99626 CDX2    HPRD  PubMed  
    Q09472 P49715 CEBPA    HPRD  PubMed  
    Q09472 P17676 CEBPB    HPRD  PubMed  
    Q09472 P49716 CEBPD    HPRD  PubMed  
    Q09472 Q14839 CHD4    HPRD  PubMed  
    Q09472 Q99966 CITED1    HPRD  PubMed  
    Q09472 Q99967 CITED2    HPRD  PubMed  
    Q09472 Q96RK1 CITED4    HPRD  PubMed  
    Q09472 Q7L5N1 COPS6    HPRD  PubMed  
    Q09472 Q92793 CREBBP    HPRD  PubMed  
    Q09472 O43186 CRX    HPRD  PubMed  
    Q09472 Q13363 CTBP1    HPRD  PubMed  
    Q09472 P56545 CTBP2    HPRD  PubMed  
    Q09472 P35222 CTNNB1    HPRD  PubMed  
    Q09472 Q10586 DBP    HPRD  PubMed  
    Q09472 Q9GZR7 DDX24    HPRD  PubMed  
    Q09472 Q86Y01 DTX1    HPRD  PubMed  
    Q09472 Q15329 E2F5    HPRD  PubMed  
    Q09472 P18146 EGR1    HPRD  PubMed  
    Q09472 EID1 EID1    HPRD  PubMed  
    Q09472 CREBBP/EP300 inhibitor 2 EID2    HPRD  PubMed  
    Q09472 E74 like factor 3 ELF3    HPRD  PubMed  
    Q09472 P19419 ELK1    HPRD  PubMed  
    Q09472 Q6PCB8 EMB    HPRD  PubMed  
    Q09472 Q09472 EP300    HPRD  PubMed  
    Q09472 Q99814 EPAS1    HPRD  PubMed  
    Q09472 P03372 ESR1    HPRD  PubMed  
    Q09472 P14921 ETS1    HPRD  PubMed  
    Q09472 P15036 ETS2    HPRD  PubMed  
    Q09472 P50549 ETV1    HPRD  PubMed  
    Q09472 P43268 ETV4    HPRD  PubMed  
    Q09472 P39748 FEN1    HPRD  PubMed  
    Q09472 Q14192 FHL2    HPRD  PubMed  
    Q09472 O43524 FOXO3    HPRD  PubMed  
    Q09472 Q06546 GABPA    HPRD  PubMed  
    Q09472 P43694 GATA4    HPRD  PubMed  
    Q09472 Q9BWX5 GATA5    HPRD  PubMed  
    Q09472 Q92908 GATA6    HPRD  PubMed  
    Q09472 Q86WP2 GPBP1    HPRD  PubMed  
    Q09472 Q13227 GPS2    HPRD  PubMed  
    Q09472 Q00403 GTF2B    HPRD  PubMed  
    Q09472 P61296 HAND2    HPRD  PubMed  
    Q09472 Q9UBN7 HDAC6    HPRD  PubMed  
    Q09472 Hect domain and RCC1 like domain 1 HERC1    HPRD  PubMed  
    Q09472 Q16665 HIF1A    HPRD  PubMed  
    Q09472 P05114 HMGN1    HPRD  PubMed  
    Q09472 P05204 HMGN2    HPRD  PubMed  
    Q09472 P20823 HNF1A    HPRD  PubMed  
    Q09472 Q00839 HNRNPU    HPRD  PubMed  
    Q09472 P31260 HOXA10    HPRD  PubMed  
    Q09472 P14653 HOXB1    HPRD  PubMed  
    Q09472 P14652 HOXB2    HPRD  PubMed  
    Q09472 P14651 HOXB3    HPRD  PubMed  
    Q09472 P17483 HOXB4    HPRD  PubMed  
    Q09472 P17509 HOXB6    HPRD  PubMed  
    Q09472 P09629 HOXB7    HPRD  PubMed  
    Q09472 P17482 HOXB9    HPRD  PubMed  
    Q09472 P09016 HOXD4    HPRD  PubMed  
    Q09472 Q9UK53 ING1    HPRD  PubMed  
    Q09472 Q9H160 ING2    HPRD  PubMed  
    Q09472 Q9UNL4 ING4    HPRD  PubMed  
    Q09472 Q8WYH8 ING5    HPRD  PubMed  
    Q09472 P10914 IRF1    HPRD  PubMed  
    Q09472 P14316 IRF2    HPRD  PubMed  
    Q09472 Q14653 IRF3    HPRD  PubMed  
    Q09472 Q92985 IRF7    HPRD  PubMed  
    Q09472 Jun dimerization protein 2 JDP2    HPRD  PubMed  
    Q09472 Junction mediating and regulatory protein JMY    HPRD  PubMed  
    Q09472 P05412 JUN    HPRD  PubMed  
    Q09472 Q92830 KAT2A    HPRD  PubMed  
    Q09472 Q92831 KAT2B    HPRD  PubMed  
    Q09472 Q92993 KAT5    HPRD  PubMed  
    Q09472 Q9Y5W3 KLF2    HPRD  PubMed  
    Q09472 Q13887 KLF5    HPRD  PubMed  
    Q09472 P52292 KPNA2    HPRD  PubMed  
    Q09472 Q9UJU2 LEF1    HPRD  PubMed  
    Q09472 O75444 MAF    HPRD  PubMed  
    Q09472 Q92585 MAML1    HPRD  PubMed  
    Q09472 Q02750 MAP2K1    HPRD  PubMed  
    Q09472 Q14676 MDC1    HPRD  PubMed  
    Q09472 Q00987 MDM2    HPRD  PubMed  
    Q09472 O15151 MDM4    HPRD  PubMed  
    Q09472 Q02078 MEF2A    HPRD  PubMed  
    Q09472 Q06413 MEF2C    HPRD  PubMed  
    Q09472 Q14814 MEF2D    HPRD  PubMed  
    Q09472 P16455 MGMT    HPRD  PubMed  
    Q09472 O75030 MITF    HPRD  PubMed  
    Q09472 Q10571 MN1    HPRD  PubMed  
    Q09472 P29372 MPG    HPRD  PubMed  
    Q09472 P49959 MRE11A    HPRD  PubMed  
    Q09472 P52701 MSH6    HPRD  PubMed  
    Q09472 P10242 MYB    HPRD  PubMed  
    Q09472 P10244 MYBL2    HPRD  PubMed  
    Q09472 P01106 MYC    HPRD  PubMed  
    Q09472 P15172 MYOD1    HPRD  PubMed  
    Q09472 Nedd4 binding protein 2 N4BP2    HPRD  PubMed  
    Q09472 P55209 NAP1L1    HPRD  PubMed  
    Q09472 Q99733 NAP1L4    HPRD  PubMed  
    Q09472 O60934 NBN    HPRD  PubMed  
    Q09472 Q15788 NCOA1    HPRD  PubMed  
    Q09472 Q15596 NCOA2    HPRD  PubMed  
    Q09472 Q9Y6Q9 NCOA3    HPRD  PubMed  
    Q09472 Q14686 NCOA6    HPRD  PubMed  
    Q09472 Q8NHV4 NEDD1    HPRD  PubMed  
    Q09472 Q969S2 NEIL2    HPRD  PubMed  
    Q09472 Q13562 NEUROD1    HPRD  PubMed  
    Q09472 O95644 NFATC1    HPRD  PubMed  
    Q09472 Q13469 NFATC2    HPRD  PubMed  
    Q09472 P25208 NFYB    HPRD  PubMed  
    Q09472 P46531 NOTCH1    HPRD  PubMed  
    Q09472 Q99743 NPAS2    HPRD  PubMed  
    Q09472 P24468 NR2F2    HPRD  PubMed  
    Q09472 P22736 NR4A1    HPRD  PubMed  
    Q09472 P52948 NUP98    HPRD  PubMed  
    Q09472 O60356 NUPR1    HPRD  PubMed  
    Q09472 Q13516 OLIG2    HPRD  PubMed  
    Q09472 P26367 PAX6    HPRD  PubMed  
    Q09472 Q06710 PAX8    HPRD  PubMed  
    Q09472 P12004 PCNA    HPRD  PubMed  
    Q09472 O00330 PDHX    HPRD  PubMed  
    Q09472 Q8IZL8 PELP1    HPRD  PubMed  
    Q09472 Q9Y6X2 PIAS3    HPRD  PubMed  
    Q09472 P29590 PML    HPRD  PubMed  
    Q09472 P20265 POU3F2    HPRD  PubMed  
    Q09472 Q07869 PPARA    HPRD  PubMed  
    Q09472 Q03181 PPARD    HPRD  PubMed  
    Q09472 Q13362 PPP2R5C    HPRD  PubMed  
    Q09472 Q05655 PRKCD    HPRD  PubMed  
    Q09472 Q92786 PROX1    HPRD  PubMed  
    Q09472 P06454 PTMA    HPRD  PubMed  
    Q09472 P54725 RAD23A    HPRD  PubMed  
    Q09472 Q92878 RAD50    HPRD  PubMed  
    Q09472 P62826 RAN    HPRD  PubMed  
    Q09472 P06400 RB1    HPRD  PubMed  
    Q09472 Q96PK6 RBM14    HPRD  PubMed  
    Q09472 Q04206 RELA    HPRD  PubMed  
    Q09472 P35398 RORA    HPRD  PubMed  
    Q09472 O75582 RPS6KA5    HPRD  PubMed  
    Q09472 Q01196 RUNX1    HPRD  PubMed  
    Q09472 Q13950 RUNX2    HPRD  PubMed  
    Q09472 Q13761 RUNX3    HPRD  PubMed  
    Q09472 Q01826 SATB1    HPRD  PubMed  
    Q09472 Q9H4L4 SENP3    HPRD  PubMed  
    Q09472 Q01105 SET    HPRD  PubMed  
    Q09472 Q96EB6 SIRT1    HPRD  PubMed  
    Q09472 Q15797 SMAD1    HPRD  PubMed  
    Q09472 Q15796 SMAD2    HPRD  PubMed  
    Q09472 P84022 SMAD3    HPRD  PubMed  
    Q09472 Q13485 SMAD4    HPRD  PubMed  
    Q09472 O15105 SMAD7    HPRD  PubMed  
    Q09472 Q8TAD8 SNIP1    HPRD  PubMed  
    Q09472 Q13573 SNW1    HPRD  PubMed  
    Q09472 P48436 SOX9    HPRD  PubMed  
    Q09472 P08047 SP1    HPRD  PubMed  
    Q09472 Q02447 SP3    HPRD  PubMed  
    Q09472 Q12772 SREBF2    HPRD  PubMed  
    Q09472 Q15532 SS18    HPRD  PubMed  
    Q09472 O75177 SS18L1    HPRD  PubMed  
    Q09472 P42224 STAT1    HPRD  PubMed  
    Q09472 P40763 STAT3    HPRD  PubMed  
    Q09472 P42229 STAT5A    HPRD  PubMed  
    Q09472 P51692 STAT5B    HPRD  PubMed  
    Q09472 P42226 STAT6    HPRD  PubMed  
    Q09472 P53999 SUB1    HPRD  PubMed  
    Q09472 O43463 SUV39H1    HPRD  PubMed  
    Q09472 O95359 TACC2    HPRD  PubMed  
    Q09472 O75528 TADA3    HPRD  PubMed  
    Q09472 P17542 TAL1    HPRD  PubMed  
    Q09472 Q99081 TCF12    HPRD  PubMed  
    Q09472 P15923 TCF3    HPRD  PubMed  
    Q09472 P15884 TCF4    HPRD  PubMed  
    Q09472 Q9NQB0 TCF7L2    HPRD  PubMed  
    Q09472 Q13569 TDG    HPRD  PubMed  
    Q09472 P05549 TFAP2A    HPRD  PubMed  
    Q09472 HIC5 TGFB1I1    HPRD  PubMed  
    Q09472 Q96RS0 TGS1    HPRD  PubMed  
    Q09472 P04637 TP53    HPRD  PubMed  
    Q09472 Q12888 TP53BP1    HPRD  PubMed  
    Q09472 Q9H3D4 TP63    HPRD  PubMed  
    Q09472 O15350 TP73    HPRD  PubMed  
    Q09472 Q96PN7 TRERF1    HPRD  PubMed  
    Q09472 Q15650 TRIP4    HPRD  PubMed  
    Q09472 Q99816 TSG101    HPRD  PubMed  
    Q09472 Q15672 TWIST1    HPRD  PubMed  
    Q09472 P63279 UBE2I    HPRD  PubMed  
    Q09472 Q15853 USF2    HPRD  PubMed  
    Q09472 P25490 YY1    HPRD  PubMed  
    Q09472 Q05516 ZBTB16    HPRD  PubMed  
    Q09472 Q13105 ZBTB17    HPRD  PubMed  
    Q09472 P37275 ZEB1    HPRD  PubMed  
    Q09472 Q8WW38 ZFPM2    HPRD  PubMed  
    Q09472 Q9UQR1 ZNF148    HPRD  PubMed  
    Q09472 P36508 ZNF76    HPRD  PubMed  
    Q09472 O95218 ZRANB2    HPRD  PubMed  
    BioGRID:108347 BioGRID:120323 ACSM5    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:106573 ACTA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:106574 ACTA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:106575 ACTB    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:106699 AHR    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108347 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:118937 ANAPC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:119537 ANAPC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:119538 ANAPC7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:106799 ANXA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:106825 APEX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:106898 ARNT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:106899 ARNTL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:106909 ARSF    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:106921 ASCL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:106922 ASCL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:107776 ATF2    BioGRID  PubMed Co-purification 
    BioGRID:108347 BioGRID:106958 ATF4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:116487 ATF5    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:115787 ATG7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:107027 ATR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:110433 ATXN3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:112221 ATXN7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:113647 BAG6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:115575 BCAS2    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:107074 BCL3    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:107076 BCL6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:108347 BioGRID:117036 BRD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:107176 C1R    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:121692 CALCOCO1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108347 BioGRID:115760 CARM1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:121487 CBX8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:107067 CCND1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:107398 CD44    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:114400 CDC16    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:107427 CDC20    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:107434 CDH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:107452 CDK2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:123555 CDT1    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:107475 CDX2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:107479 CEBPA    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:108347 BioGRID:107480 CEBPB    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:109324 CFH    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:107569 CHUK    BioGRID  PubMed Co-localization 
    BioGRID:108347 BioGRID:110572 CITED1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:115649 CITED2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:127875 CITED4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:114944 CLOCK    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:107623 CLTC    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:110912 CNOT4    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:112763 CNTN2    BioGRID  PubMed Phenotypic Suppression; Reconstituted Complex 
    BioGRID:108347 BioGRID:116176 COPS6    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:107775 CREB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:128308 CRTC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:107796 CRX    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:107869 CTBP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:107870 CTBP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:107871 CTF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Luminescence; Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex 
    BioGRID:108347 BioGRID:108332 CTTN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:223714 Cdk9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:107980 DAO    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:108010 DDB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:115776 DDX17    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:121353 DDX24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:108021 DDX5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:117525 DECR2    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:113643 DEK    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:108173 DTX1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108347 BioGRID:108278 EGR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:117243 EID1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:108317 ELK1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex 
    BioGRID:108347 BioGRID:122060 ELSPBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:108348 EPAS1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:108347 BioGRID:108370 EPO    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:107581 ERCC8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:108404 ESR2    BioGRID  PubMed Affinity Capture-Western; FRET 
    BioGRID:108347 BioGRID:108414 ETS1    BioGRID  PubMed Phenotypic Enhancement; Protein-peptide; Reconstituted Complex 
    BioGRID:108347 BioGRID:108415 ETS2    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Protein-peptide; Reconstituted Complex 
    BioGRID:108347 BioGRID:108416 ETV1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:236625 Ep300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:117625 FBXL5    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:117657 FBXO3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:117603 FBXW2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:117645 FBXW8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:108528 FEN1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:108636 FOS    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:108637 FOSB    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:113742 FOSL1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:108638 FOSL2    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:108598 FOXO3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:108823 GAA    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:108826 GABPA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:108868 GAPDH    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:676699 GATA1    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:108894 GATA2    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:108896 GATA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:108897 GATA6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:109063 GOLGA2    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:109132 GPS2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:109142 GRB2    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:116995 GRIP1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:109214 GTF2B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:109230 GTF3C1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:109231 GTF3C2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:114739 GTF3C3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:114737 GTF3C5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:199841 Gata4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:114850 HAND2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:117927 HBP1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:1205534 HCVgp1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Positive Genetic; Reconstituted Complex 
    BioGRID:108347 BioGRID:109316 HDAC2    BioGRID  PubMed Positive Genetic 
    BioGRID:108347 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:115330 HDAC6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:119613 HDAC7    BioGRID  PubMed Positive Genetic 
    BioGRID:108347 BioGRID:114439 HERC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:118815 HIPK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:109275 HIST1H1A    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:109262 HIST1H1D    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:113931 HIST1H2AB    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:109271 HIST1H2BB    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:113946 HIST1H3A    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:113955 HIST1H4A    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:130469 HIST2H2AB    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:113934 HIST2H2AC    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:113945 HIST2H2BE    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:126025 HIST2H3C    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:113966 HIST2H4A    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:113895 HIST3H3    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:125732 HIST4H4    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:109393 HMGN1    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:109394 HMGN2    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:112789 HNF1A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:109433 HNRNPU    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:108347 BioGRID:116281 HNRNPUL1    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:109476 HOXD10    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:109473 HOXD4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:122900 HPS6    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:109556 HSP90AA2    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:109790 IL8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:116185 IMMT    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:109833 ING1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:109834 ING2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:119331 ING4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:124016 ING5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:109867 IRF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:109868 IRF2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:109869 IRF3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:108347 BioGRID:109871 IRF5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:109873 IRF7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:109905 ITIH3    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:126372 JMY    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-fractionation; Reconstituted Complex 
    BioGRID:108347 BioGRID:109929 JUNB    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:109930 JUND    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:113703 KAT6A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:119958 KCTD5    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:116667 KDM1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:114040 KLF11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:119642 KLF13    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:123771 KLF16    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:114726 KLF4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:107153 KLF5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:116435 KLF8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:110036 KPNA2    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:110073 KRT18    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:119354 LEF1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:114642 LRRFIP1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:108347 BioGRID:110269 MAF    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108347 BioGRID:110284 MAGEA11    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:114879 MAGED1    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:115138 MAML1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:110381 MAP3K5    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:122969 MAP9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:107819 MAPK14    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:110308 MAPT    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:110319 MAX    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:114406 MCM3AP    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:115014 MDC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-fractionation; Reconstituted Complex 
    BioGRID:108347 BioGRID:110359 MDM4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:110369 MEF2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:110372 MEF2C    BioGRID  PubMed Phenotypic Enhancement; Reconstituted Complex 
    BioGRID:108347 BioGRID:110373 MEF2D    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:110501 MRE11A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:109211 MSH6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:120457 MSTO1    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:114562 MTA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:110620 MTF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:110687 MYB    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:108347 BioGRID:110690 MYBL2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:108347 BioGRID:110737 MYOD1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Phenotypic Enhancement; Reconstituted Complex 
    BioGRID:108347 BioGRID:120848 N4BP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:122500 NABP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:110754 NAP1L1    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:110757 NAP1L4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:110763 NBN    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:108347 BioGRID:114200 NCOA1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:108347 BioGRID:115761 NCOA2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108347 BioGRID:113841 NCOA3    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:116691 NCOA6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:114974 NCOR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:125728 NEDD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:110833 NEUROD1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:110835 NEUROG1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:108347 BioGRID:110845 NFATC1    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:110846 NFATC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:110857 NFKB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:110866 NFYA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:110867 NFYB    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:110913 NOTCH1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:108347 BioGRID:116025 NOXA1    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:110923 NPAS2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:110929 NPM1    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:115296 NR1H4    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:109165 NR3C1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:109407 NR4A1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:110982 NUP98    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:117695 NUPR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:129174 NUTM1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:111098 PAK2    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:111113 PAX5    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:111114 PAX6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:116625 PAXIP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:111136 PCK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:111137 PCK2    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:117973 PELP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:111260 PGR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:115673 PIAS3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:111317 PIN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:111332 PKM    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:108347 BioGRID:111341 PLAGL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:111356 PLG    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:111373 PLSCR1    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:121340 PLSCR2    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:111421 POLD2    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:111426 POLR2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:111450 POU3F2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:111461 PPARA    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:111463 PPARD    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:111464 PPARG    BioGRID  PubMed Affinity Capture-Luminescence; Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:116097 PPARGC1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:113575 PRDM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:111549 PRKAA1    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:109512 PRMT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:111613 PROX1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108347 BioGRID:111724 PTMA    BioGRID  PubMed Phenotypic Enhancement; Reconstituted Complex 
    BioGRID:108347 BioGRID:111730 PTMS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:115417 RAD50    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:111849 RARA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:115700 RBM14    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:114798 RECQL4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:111898 REL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:112022 RORA    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:112074 RPL27    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:114676 RPS6KA5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:112112 RPS6KB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:112113 RPS6KB2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:107309 RUNX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:107308 RUNX2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:107312 RUNX3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:112168 RXRA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:121917 SAV1    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:112313 SEPP1    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:118987 SERTAD1    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:112343 SGCG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:116983 SIRT1    BioGRID  PubMed Positive Genetic 
    BioGRID:108347 BioGRID:116593 SIRT2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Positive Genetic 
    BioGRID:108347 BioGRID:116982 SIRT3    BioGRID  PubMed Negative Genetic 
    BioGRID:108347 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:110261 SMAD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108347 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:110264 SMAD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:110265 SMAD5    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108347 BioGRID:110267 SMAD7    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:112479 SMARCA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:122864 SNIP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:116597 SNW1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:112542 SOX4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:112545 SOX9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:112553 SP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:114396 SPHK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:112592 SRC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:116058 SRCAP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:112598 SREBF1    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:108347 BioGRID:112599 SREBF2    BioGRID  PubMed Far Western 
    BioGRID:108347 BioGRID:112614 SRY    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:112638 SS18    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:117505 SS18L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:112649 STAT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:112650 STAT2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:112653 STAT5A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:112655 STAT6    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex 
    BioGRID:108347 BioGRID:116342 STRAP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:116127 SUB1    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:203522 Stat2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:203523 Stat3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:115830 TACC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:115737 TADA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:114483 TAF1B    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:112749 TAL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:112771 TBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:119027 TBX21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:112798 TCF12    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108347 BioGRID:112791 TCF3    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-fractionation; Co-localization; Phenotypic Enhancement; Two-hybrid 
    BioGRID:108347 BioGRID:112787 TCF4    BioGRID  PubMed Affinity Capture-Luminescence; Affinity Capture-Western 
    BioGRID:108347 BioGRID:112795 TCF7L2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:108347 BioGRID:113783 TCL1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:112855 TDG    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:112878 TFAP2A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108347 BioGRID:112904 TGFBR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:125179 TGS1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:112922 THPO    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:112923 THRA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:122078 TINAGL1    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:122573 TNIP2    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:115485 TNK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Luminescence; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-fractionation; Co-localization; Phenotypic Suppression; Protein-peptide; Reconstituted Complex 
    BioGRID:108347 BioGRID:113011 TP53BP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108347 BioGRID:113014 TP73    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Co-purification; Reconstituted Complex 
    BioGRID:108347 BioGRID:113038 TRAF2    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:120919 TRERF1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex 
    BioGRID:108347 BioGRID:114735 TRIP4    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:113102 TSG101    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108347 BioGRID:113142 TWIST1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:108347 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108347 BioGRID:119007 UBQLN1    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:113237 USF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:113238 USF2    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:113264 VDR    BioGRID  PubMed Co-localization 
    BioGRID:108347 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:121664 VPS18    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:122841 WDR59    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:113344 XPA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:108822 XRCC6    BioGRID  PubMed Biochemical Activity 
    BioGRID:108347 BioGRID:115684 YAP1    BioGRID  PubMed Co-localization 
    BioGRID:108347 BioGRID:110959 YBX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:108347 BioGRID:113498 ZBTB16    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:113503 ZBTB17    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:119242 ZBTB7B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:123141 ZC3H12A    BioGRID  PubMed Two-hybrid 
    BioGRID:108347 BioGRID:113501 ZNF148    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108347 BioGRID:113448 ZNF76    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108347 BioGRID:59388 fliI    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:108347 BioGRID:1205538 gag-pol    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; FRET; Reconstituted Complex 
    BioGRID:108347 BioGRID:37329 pop-1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:1205541 tat    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108347 BioGRID:1776967 vIRF-1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108347 BioGRID:1776996 vIRF-3    BioGRID  PubMed Affinity Capture-Western 
    • ATF-2 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      ATF-2 transcription factor network, organism-specific biosystem
      ATF-2 transcription factor network
    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
    • BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem (from REACTOME)
      BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK and BMAL1:NPAS2 heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz...
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cellular response to hypoxia, organism-specific biosystem (from REACTOME)
      Cellular response to hypoxia, organism-specific biosystemOxygen plays a central role in the functioning of human cells: it is both essential for normal metabolism and toxic. To begin the annotation of stress responses in Reactome, we have annotated one asp...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Circadian Clock, organism-specific biosystem (from REACTOME)
      Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 heterodimer transactivates CRY and PER genes by binding E-box element...
    • Circadian Repression of Expression by REV-ERBA, organism-specific biosystem (from REACTOME)
      Circadian Repression of Expression by REV-ERBA, organism-specific biosystemREV-ERBA binds DNA elements very similar to those bound by the transcription activator RORA. RORAREV-ERBA bound to DNA and heme recruits the corepressors NCoR and HDAC3 to repress transcription. Thu...
    • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystemWhen found in cis, HD and PEST domain mutations act synergistically, increasing NOTCH1 transcriptional activity up to ~40-fold, compared with up to ~10-fold and up to ~2-fold increase with HD mutatio...
    • Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystemAs NOTCH1 PEST domain is intracellular, NOTCH1 PEST domain mutants are expected to behave as the wild-type NOTCH1 with respect to ligand binding and proteolytic cleavage mediated activation of signal...
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • Energy Metabolism, organism-specific biosystem (from WikiPathways)
      Energy Metabolism, organism-specific biosystemThe PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of ...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • FBXW7 Mutants and NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
      FBXW7 Mutants and NOTCH1 in Cancer, organism-specific biosystemFBXW7 (FBW7) is a component of the SCF (SKP1, CUL1, and F-box protein) ubiquitin ligase complex SCF-FBW7 which is involved in the degradation of NOTCH1 (Oberg et al. 2001, Wu et al. 2001, Fryer et al...
    • FOXA1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXA1 transcription factor network, organism-specific biosystem
      FOXA1 transcription factor network
    • FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXM1 transcription factor network, organism-specific biosystem
      FOXM1 transcription factor network
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
      HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
    • HIF-1-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      HIF-1-alpha transcription factor network, organism-specific biosystem
      HIF-1-alpha transcription factor network
    • HIF-2-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      HIF-2-alpha transcription factor network, organism-specific biosystem
      HIF-2-alpha transcription factor network
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
      IFN-gamma pathway, organism-specific biosystem
      IFN-gamma pathway
    • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-4 signaling Pathway, organism-specific biosystemInterleukin-4 belongs to the IL-2 family of cytokines, which includes IL-2, IL-7, IL-9, IL-15 and IL-21. It signals through 2 different receptor complexes; Receptor complex 1 comprises of IL-4 recept...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Melanogenesis, organism-specific biosystem (from KEGG)
      Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Melanogenesis, conserved biosystem (from KEGG)
      Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
      NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
    • Notch signaling pathway, organism-specific biosystem (from KEGG)
      Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Notch signaling pathway, organism-specific biosystem
      Notch signaling pathway
    • Notch signaling pathway, conserved biosystem (from KEGG)
      Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
      Notch-mediated HES/HEY network, organism-specific biosystem
      Notch-mediated HES/HEY network
    • PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
      PPARA Activates Gene Expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Pre-NOTCH Expression and Processing, organism-specific biosystem (from REACTOME)
      Pre-NOTCH Expression and Processing, organism-specific biosystemIn humans and other mammals the NOTCH gene family has four members, NOTCH1, NOTCH2, NOTCH3 and NOTCH4, encoded on four different chromosomes. Their transcription is developmentally regulated and tiss...
    • Pre-NOTCH Transcription and Translation, organism-specific biosystem (from REACTOME)
      Pre-NOTCH Transcription and Translation, organism-specific biosystemIn humans, the NOTCH protein family has four members: NOTCH1, NOTCH2, NOTCH3 and NOTCH4. NOTCH1 protein was identified first, as the product of a chromosome 9 gene translocated in T-cell acute lympho...
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • RORA Activates Circadian Expression, organism-specific biosystem (from REACTOME)
      RORA Activates Circadian Expression, organism-specific biosystemAs inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.
    • Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Androgen receptor activity, organism-specific biosystem
      Regulation of Androgen receptor activity
    • Regulation of Gene Expression by Hypoxia-inducible Factor, organism-specific biosystem (from REACTOME)
      Regulation of Gene Expression by Hypoxia-inducible Factor, organism-specific biosystemHIF-alpha (HIF1A, HIF2A (EPAS1), HIF3A) is translocated to the nucleus, possibly by two pathways: importin 4/7 (Chachami et al. 2009) and importin alpha/beta (Depping et al. 2008). Once in the nucleu...
    • Regulation of Hypoxia-inducible Factor (HIF) by Oxygen, organism-specific biosystem (from REACTOME)
      Regulation of Hypoxia-inducible Factor (HIF) by Oxygen, organism-specific biosystemIn the presence of oxygen members of the transcription factor family HIF-alpha, comprising HIF1A, HIF2A (EPAS1), and HIF3A, are hydroxylated on proline residues by PHD1 (EGLN2), PHD2 (EGLN1), and PHD...
    • Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
      Role of Calcineurin-dependent NFAT signaling in lymphocytes
    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
      Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • Signaling by NOTCH1 HD Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 HD Domain Mutants in Cancer, organism-specific biosystemNOTCH1 heterodimerization domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL) (Weng et al. 2004) and result in constitutive activity of NOTCH1 mutants (Malecki et al....
    • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystemMutations in the heterodimerization domain (HD) and PEST domain of NOTCH1 are frequently found in cis in T-cell acute lymphoblastic leukemia. While HD mutations alone result in up to ~10-fold increas...
    • Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystemNOTCH1 PEST domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL). PEST domain mutations interfere with ubiquitination-mediated NOTCH1 downregulation and result in prol...
    • Signaling by NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 in Cancer, organism-specific biosystemHuman NOTCH1 was cloned as a chromosome 9 gene, translocated to the T-cell beta receptor (TCBR) promoter on chromosome 7 in T-cell acute lymphoblastic leukemia (T-ALL) (Ellisen et al. 1991). This tra...
    • Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, organism-specific biosystemHuman NOTCH1 was cloned as a chromosome 9 gene, translocated to the T-cell beta receptor (TCBR) promoter on chromosome 7 in T-cell acute lymphoblastic leukemia (T-ALL) (Ellisen et al. 1991). The tran...
    • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class I, organism-specific biosystem
      Signaling events mediated by HDAC Class I
    • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class III, organism-specific biosystem
      Signaling events mediated by HDAC Class III
    • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TRAF3-dependent IRF activation pathway, organism-specific biosystem (from REACTOME)
      TRAF3-dependent IRF activation pathway, organism-specific biosystemIPS-1/MAVS/Cardif/VISA with its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the RIG-I/MDA5 signaling complex. TRAF3 acts as a scaffold for the assembly of a signa...
    • TRAF6 mediated IRF7 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated IRF7 activation, organism-specific biosystemTRAF6 is crucial for both RIG-I- and MDA5-mediated antiviral responses. The absence of TRAF6 resulted in enhanced viral replication and a significant reduction in the production of type I IFNs and IL...
    • Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional activation, organism-specific biosystem
      Validated targets of C-MYC transcriptional activation
    • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional repression, organism-specific biosystem
      Validated targets of C-MYC transcriptional repression
    • Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway Interaction Database)
      Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
      Validated transcriptional targets of AP1 family members Fra1 and Fra2
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
      p53 pathway, organism-specific biosystem
      p53 pathway

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    RNA polymerase II activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		  
    acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		  
    androgen receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lysine N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		  
    p53 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transferase activity, transferring acyl groups IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    N-terminal peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Notch signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to hypoxia TAS
    Traceable Author Statement
    more info
    		  
    heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone H4 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    internal peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lung development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation by host of viral transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
    Traceable Author Statement
    more info
    		  
    regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    virus-host interaction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    histone acetyltransferase p300
    Names
    histone acetyltransferase p300
    p300 HAT
    E1A-binding protein, 300kD
    E1A-associated protein p300
    NP_001420.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009817.1 RefSeqGene

      Range
      5001..92468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001429.3 → NP_001420.2  histone acetyltransferase p300

      Status: REVIEWED

      Source sequence(s)
      AL035658, BC053889, CN278277, CN278282, DB047746, N57495, U01877
      Consensus CDS
      CCDS14010.1
      UniProtKB/Swiss-Prot
      Q09472
      UniProtKB/TrEMBL
      Q7Z6C1
      Related
      ENSP00000263253, OTTHUMP00000198754, ENST00000263253, OTTHUMT00000320600
      Conserved Domains (7) summary
      cd02337
      Location:1668 – 1708
      Blast Score: 241
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd05495
      Location:1051 – 1158
      Blast Score: 623
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      pfam02172
      Location:566 – 646
      Blast Score: 399
      KIX; KIX domain
      pfam09030
      Location:2010 – 2096
      Blast Score: 155
      Creb_binding; Creb binding
      pfam02135
      Location:336 – 416
      Blast Score: 277
      zf-TAZ; TAZ zinc finger
      pfam06001
      Location:1155 – 1196
      Blast Score: 240
      DUF902; Domain of Unknown Function (DUF902)
      pfam08214
      Location:1306 – 1608
      Blast Score: 869
      KAT11; Histone acetylation protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000022.10 Reference GRCh37.p10 Primary Assembly

      Range
      41488614..41576081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000154.1 Alternate HuRef

      Range
      24453007..24540433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018933.1 Alternate CHM1_1.0

      Range
      25403423..25491038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01055620.1 (7443..34620) None
    genomic ABBA01055621.1 None
    genomic AL035658.7 (102..15316) None
    genomic AL080243.21 (116992..176287) None
    genomic AL096765.12 (101..13053) None
    genomic AMYH01012797.1 (27649..45346) None
    genomic AMYH01012798.1 None
    genomic AMYH01012799.1 None
    genomic CH471095.1 EAW60408.1
    genomic CS498706.1 CAM82745.1
    genomic DQ229147.1 ABB16440.1
    mRNA AA235167.1 None
    mRNA AI302618.1 None
    mRNA BC053889.1 AAH53889.1
    mRNA BQ428177.1 None
    mRNA BQ921059.1 None
    mRNA BQ930911.1 None
    mRNA CA393789.1 None
    mRNA CB132795.1 None
    mRNA CB155618.1 None
    mRNA CF130065.1 None
    mRNA CN278277.1 None
    mRNA CN278282.1 None
    mRNA D53020.1 None
    mRNA DB047746.1 None
    mRNA N57495.1 None
    mRNA U01877.1 AAA18639.1
    other-genetic AB385004.1 BAG10860.1
    other-genetic BC172280.1 AAI72280.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09472.2 GenPept UniProtKB/Swiss-Prot:Q09472

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
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        3D structure of a gene
      • BioAssay
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      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • GTR
        GTR associated with a gene
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
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        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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