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FAM219A family with sequence similarity 219 member A [ Homo sapiens (human) ]

Gene ID: 203259, updated on 8-May-2016
Official Symbol
FAM219Aprovided by HGNC
Official Full Name
family with sequence similarity 219 member Aprovided by HGNC
Primary source
HGNC:HGNC:19920
See related
Ensembl:ENSG00000164970 HPRD:12950; Vega:OTTHUMG00000019822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf25
Summary
The protein encoded by this gene has homologs that have been identified in mouse, macaque, etc organisms. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
Orthologs
Location:
9p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (34398184..34458610, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34398182..34458568, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene kinesin family member 24 Neighboring gene nudix hydrolase 2 Neighboring gene KIAA1161 Neighboring gene chromosome 9 open reading frame 24 Neighboring gene uncharacterized LOC105376022 Neighboring gene dynein axonemal intermediate chain 1 Neighboring gene energy homeostasis associated

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ39031
Preferred Names
protein FAM219A
Names
family with sequence similarity 219, member A
uncharacterized protein C9orf25

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027971.1 RefSeqGene

    Range
    5001..65387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184940.1NP_001171869.1  protein FAM219A isoform 1

    See identical proteins and their annotated locations for NP_001171869.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AK096350, AK299882, AL356494, BC025348
    Consensus CDS
    CCDS55304.1
    UniProtKB/Swiss-Prot
    Q8IW50
    Related
    ENSP00000392452, ENST00000445726
    Conserved Domains (1) summary
    pfam15260
    Location:54185
    FAM219A; Protein family FAM219A
  2. NM_001184941.1NP_001171870.1  protein FAM219A isoform 2

    See identical proteins and their annotated locations for NP_001171870.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) lacks an internal aa when it is compared to isoform 1.
    Source sequence(s)
    AK096350, AK299882, AL356494, BC025348
    UniProtKB/Swiss-Prot
    Q8IW50
    Related
    ENSP00000368382, OTTHUMP00000021273, ENST00000379089, OTTHUMT00000052179
    Conserved Domains (1) summary
    pfam15260
    Location:54184
    FAM219A; Protein family FAM219A
  3. NM_001184942.1NP_001171871.1  protein FAM219A isoform 3

    See identical proteins and their annotated locations for NP_001171871.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK294054, AL356494, BC025348
    UniProtKB/Swiss-Prot
    Q8IW50
    Related
    ENSP00000368371, OTTHUMP00000021279, ENST00000379080, OTTHUMT00000052185
    Conserved Domains (1) summary
    pfam15260
    Location:43173
    FAM219A; Protein family FAM219A
  4. NM_001184943.1NP_001171872.1  protein FAM219A isoform 5

    See identical proteins and their annotated locations for NP_001171872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 5) lacks a segment in the N-terminal region and an internal aa when it is compared to isoform 1.
    Source sequence(s)
    AK096350, AL356494, BC025348, DA110626
    UniProtKB/Swiss-Prot
    Q8IW50
    Related
    ENSP00000368380, OTTHUMP00000021274, ENST00000379087, OTTHUMT00000052180
    Conserved Domains (1) summary
    pfam15260
    Location:37167
    FAM219A; Protein family FAM219A
  5. NM_001184945.1NP_001171874.1  protein FAM219A isoform 7

    See identical proteins and their annotated locations for NP_001171874.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses three different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 7) lacks two segments and an internal aa when it is compared to isoform 1.
    Source sequence(s)
    AK294054, AL356494, BC025348, BC041009
    UniProtKB/Swiss-Prot
    Q8IW50
    Conserved Domains (1) summary
    pfam15260
    Location:26156
    FAM219A; Protein family FAM219A
  6. NM_147202.1NP_671735.1  protein FAM219A isoform 4

    See identical proteins and their annotated locations for NP_671735.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 4) lacks an internal segment when it is compared to isoform 1.
    Source sequence(s)
    AK096350, AL356494, BC025348
    Consensus CDS
    CCDS6556.1
    UniProtKB/Swiss-Prot
    Q8IW50
    Related
    ENSP00000297620, OTTHUMP00000159910, ENST00000297620, OTTHUMT00000251703
    Conserved Domains (1) summary
    pfam15260
    Location:37168
    FAM219A; Protein family FAM219A

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    34398184..34458610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517798.1XP_011516100.1  

    See identical proteins and their annotated locations for XP_011516100.1

    Related
    ENSP00000368372, OTTHUMP00000021276, ENST00000379081, OTTHUMT00000052182
    Conserved Domains (1) summary
    pfam15260
    Location:26157
    FAM219A; Protein family FAM219A
  2. XM_011517797.1XP_011516099.1  

    See identical proteins and their annotated locations for XP_011516099.1

    Conserved Domains (1) summary
    pfam15260
    Location:43174
    FAM219A; Protein family FAM219A
  3. XM_011517801.1XP_011516103.1  

    See identical proteins and their annotated locations for XP_011516103.1

    Conserved Domains (1) summary
    pfam15260
    Location:1116
    FAM219A; Protein family FAM219A
  4. XM_006716740.2XP_006716803.1  

    See identical proteins and their annotated locations for XP_006716803.1

    Conserved Domains (1) summary
    pfam15260
    Location:13144
    FAM219A; Protein family FAM219A
  5. XM_005251402.3XP_005251459.1  

    See identical proteins and their annotated locations for XP_005251459.1

    Conserved Domains (1) summary
    pfam15260
    Location:13144
    FAM219A; Protein family FAM219A
  6. XM_011517799.1XP_011516101.1  

    See identical proteins and their annotated locations for XP_011516101.1

    Conserved Domains (1) summary
    pfam15260
    Location:1116
    FAM219A; Protein family FAM219A
  7. XM_011517800.1XP_011516102.1  

    See identical proteins and their annotated locations for XP_011516102.1

    Conserved Domains (1) summary
    pfam15260
    Location:1116
    FAM219A; Protein family FAM219A

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    34397971..34458350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001184944.1: Suppressed sequence

    Description
    NM_001184944.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.