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    FAM219A family with sequence similarity 219, member A [ Homo sapiens ]

    Gene ID: 203259, updated on 11-May-2012
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    Summary

    Official Symbol
    FAM219Aprovided by HGNC
    Official Full Name
    family with sequence similarity 219, member Aprovided by HGNC
    Primary source
    HGNC:19920
    Locus tag
    RP11-573M23.5
    See related
    Ensembl:ENSG00000164970; HPRD:12950; Vega:OTTHUMG00000019822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C9orf25; bA573M23.5; FLJ39031
    Summary
    The protein encoded by this gene has homologs that have been identified in mouse, macaque, etc organisms. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
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    Genomic context

    Location :
    9p13.3
    Sequence :
    Chromosome: 9; NC_000009.11 (34398182..34458568, complement)
    See FAM219A in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene KIAA1161 Neighboring gene chromosome 9 open reading frame 24 Neighboring gene dynein, axonemal, intermediate chain 1 Neighboring gene energy homeostasis associated

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
    5. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.

    See all (11) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8IW50 O43924 PDE6D    HPRD  PubMed  
    Q8IW50 Q14181 POLA2    HPRD  PubMed  
    Q8IW50 Q8IX03 WWC1    HPRD  PubMed  
    BioGRID:128461 BioGRID:119824 CSNK1G1    BioGRID  PubMed Two-hybrid 
    BioGRID:128461 BioGRID:117432 NIPSNAP3A    BioGRID  PubMed Two-hybrid 
    BioGRID:128461 BioGRID:111173 PDE6D    BioGRID  PubMed Two-hybrid 
    BioGRID:128461 BioGRID:117176 POLA2    BioGRID  PubMed Two-hybrid 
    BioGRID:128461 BioGRID:115547 SPRY2    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

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    General protein information

    Preferred Names
    uncharacterized protein C9orf25
    Names
    uncharacterized protein C9orf25
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027971.1 RefSeqGene

      Range
      5001..65387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184940.1 → NP_001171869.1  uncharacterized protein C9orf25 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AK096350, AK299882, AL356494, BC025348
      Consensus CDS
      CCDS55304.1
      UniProtKB/Swiss-Prot
      Q8IW50
      Related
      ENSP00000392452, ENST00000445726

    2. NM_001184941.1 → NP_001171870.1  uncharacterized protein C9orf25 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) lacks an internal aa when it is compared to isoform 1.
      Source sequence(s)
      AK096350, AK299882, AL356494, BC025348
      UniProtKB/Swiss-Prot
      Q8IW50
      Related
      ENSP00000368382, OTTHUMP00000021273, ENST00000379089, OTTHUMT00000052179

    3. NM_001184942.1 → NP_001171871.1  uncharacterized protein C9orf25 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK294054, AL356494, BC025348
      UniProtKB/Swiss-Prot
      Q8IW50
      Related
      ENSP00000368371, OTTHUMP00000021279, ENST00000379080, OTTHUMT00000052185

    4. NM_001184943.1 → NP_001171872.1  uncharacterized protein C9orf25 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 5) lacks a segment in the N-terminal region and an internal aa when it is compared to isoform 1.
      Source sequence(s)
      AK096350, AL356494, BC025348, DA110626
      UniProtKB/Swiss-Prot
      Q8IW50
      Related
      ENSP00000368380, OTTHUMP00000021274, ENST00000379087, OTTHUMT00000052180

    5. NM_001184945.1 → NP_001171874.1  uncharacterized protein C9orf25 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses three different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 7) lacks two segments and an internal aa when it is compared to isoform 1.
      Source sequence(s)
      AK294054, AL356494, BC025348, BC041009
      UniProtKB/Swiss-Prot
      Q8IW50
      Related
      ENSP00000368372, OTTHUMP00000021276, ENST00000379081, OTTHUMT00000052182

    6. NM_147202.1 → NP_671735.1  uncharacterized protein C9orf25 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 4) lacks an internal segment when it is compared to isoform 1.
      Source sequence(s)
      AK096350, AL356494, BC025348
      Consensus CDS
      CCDS6556.1
      UniProtKB/Swiss-Prot
      Q8IW50
      Related
      ENSP00000297620, OTTHUMP00000159910, ENST00000297620, OTTHUMT00000251703

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      34398182..34458568, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      34353280..34412900, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001184944.1: Suppressed sequence

      Description
      NM_001184944.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL160270.19 CAI13146.1
      CAI13147.1
      CAI13149.1
      CAI13150.1
      CAI13151.1
      CAI13152.1
      CAI13153.1
      CAM16095.1
    genomic AL160270.19 CAI13146.1
      CAI13147.1
      CAI13149.1
      CAI13150.1
      CAI13151.1
      CAI13152.1
      CAI13153.1
      CAM16095.1
    genomic AL160270.19 CAI13146.1
      CAI13147.1
      CAI13149.1
      CAI13150.1
      CAI13151.1
      CAI13152.1
      CAI13153.1
      CAM16095.1
    genomic AL356494.13 CAI15967.1
      CAI15969.1
      CAI15970.1
      CAI15971.1
      CAI15972.1
      CAI15973.1
      CAI15974.1
      CAM22385.1
    genomic AL356494.13 CAI15967.1
      CAI15969.1
      CAI15970.1
      CAI15971.1
      CAI15972.1
      CAI15973.1
      CAI15974.1
      CAM22385.1
    genomic AL356494.13 CAI15967.1
      CAI15969.1
      CAI15970.1
      CAI15971.1
      CAI15972.1
      CAI15973.1
      CAI15974.1
      CAM22385.1
    genomic CH471071.2 EAW58454.1
      EAW58455.1
    mRNA AF131828.1 None
    mRNA AK022819.1 None
    mRNA AK026087.1 None
    mRNA AK091262.1 None
    mRNA AK096350.1 BAG53270.1
    mRNA AK123887.1 None
    mRNA AK294054.1 BAG57402.1
    mRNA AK299882.1 BAG61730.1
    mRNA AL833397.1 None
    mRNA BC015785.1 None
    mRNA BC025348.1 AAH25348.1
    mRNA BC041009.2 AAH41009.1
    mRNA DA110626.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T593 GenPept UniProtKB/TrEMBL:Q5T593
    Q8IW50.3 GenPept UniProtKB/Swiss-Prot:Q8IW50
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    Additional Links

    Gene LinkOut

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