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LGI3 leucine-rich repeat LGI family member 3 [ Homo sapiens (human) ]

Gene ID: 203190, updated on 12-May-2016
Official Symbol
LGI3provided by HGNC
Official Full Name
leucine-rich repeat LGI family member 3provided by HGNC
Primary source
HGNC:HGNC:18711
See related
Ensembl:ENSG00000168481 HPRD:06432; MIM:608302; Vega:OTTHUMG00000131599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LGIL4
Orthologs
Location:
8p21.3
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (22146830..22156831, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22004343..22014344, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene hair growth associated Neighboring gene receptor accessory protein 4 Neighboring gene surfactant protein C Neighboring gene bone morphogenetic protein 1 Neighboring gene uncharacterized LOC105379319

NHGRI GWAS Catalog

Description
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
NHGRI GWA Catalog
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • LGI-ADAM interactions, organism-specific biosystem (from REACTOME)
    LGI-ADAM interactions, organism-specific biosystemSynapse formation and maturation require multiple interactions between presynaptic and postsynaptic neurons. These interactions are mediated by a diverse set of synaptogenic proteins (Kegel et al. 20...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
exocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
leucine-rich repeat LGI family member 3
Names
LGI1-like protein 4
leucine-rich glioma-inactivated protein 3
leucine-rich repeat LGI family, member 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139278.2NP_644807.1  leucine-rich repeat LGI family member 3 precursor

    See identical proteins and their annotated locations for NP_644807.1

    Status: VALIDATED

    Source sequence(s)
    AJ487961, BC042542
    Consensus CDS
    CCDS6025.1
    UniProtKB/Swiss-Prot
    Q8N145
    Related
    ENSP00000302297, OTTHUMP00000162355, ENST00000306317, OTTHUMT00000254482
    Conserved Domains (5) summary
    pfam03736
    Location:454497
    EPTP; EPTP domain
    smart00082
    Location:170218
    LRRCT; Leucine rich repeat C-terminal domain
    pfam12799
    Location:113152
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:112172
    LRR_8; Leucine rich repeat
    sd00031
    Location:6889
    LRR_1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    22146830..22156831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    22206009..22216003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)