Cxcl12 chemokine (C-X-C motif) ligand 12 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Cxcl12provided by MGI
Official Full Name: chemokine (C-X-C motif) ligand 12provided by MGI
Primary source: MGI:103556
See related: Ensembl:ENSMUSG00000061353; Vega:OTTMUSG00000022768
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pbsf; Sdf1; Tlsf; Tpar1; Scyb12
Summary: This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Genomic context

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Location :: 6 F1; 6 54.81 cM

Sequence :: Chromosome: 6; NC_000072.6 (117168535..117181368)

See Cxcl12 in Epigenomics, MapViewer

Chromosome 6 - NC_000072.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12
Title: Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12.
AKT-dependent upregulation of AP-2alpha is essential for carbon monoxide-induced SDF-1alpha expression and myocardial repair after ischemic injury.
Title: Activator protein-2α mediates carbon monoxide-induced stromal cell-derived factor-1α expression and vascularization in ischemic heart.
expression of CXCL12 from stromal cells in the perivascular region, including endothelial cells and mesenchymal progenitors, supports hematopoietic stem cells
Title: CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance.
These results demonstrated a novel role of SDF-1 signaling in regulating BMP2-induced chondrogenic differentiation in vitro.
Title: Regulatory role of stromal cell-derived factor-1 in bone morphogenetic protein-2-induced chondrogenic differentiation in vitro.
Hypoxic preconditioning may improve the survival and retention of c-kit+ CPCs in the ischemic heart tissue through activating the SDF-1alpha/CXCR4 axis
Title: Hypoxic preconditioning improves survival of cardiac progenitor cells: role of stromal cell derived factor-1α-CXCR4 axis.
overexpression of SDF-1alpha enhanced cardiac stem cellss migration in vitro and engraftment of transplanted cardiac stem cells and reduced infarcted size via CXCR4/PI3K pathway
Title: Overexpression of SDF-1α enhanced migration and engraftment of cardiac stem cells and reduced infarcted size via CXCR4/PI3K pathway.
spermatogonial stem cell chemotactic factor in vitro and in vivo
Title: Reconstitution of mouse spermatogonial stem cell niches in culture.
Expression of CXCL12 by tumor cells results in increased macrophage and microvessel density and in vivo invasiveness.
Title: Contribution of CXCL12 secretion to invasion of breast cancer cells.
G-CSF/SCF can effectively induce bone marrow mononuclear cell mobilization by disrupting the balance of CXCL12/CXCR4 signaling.
Title: Mobilization efficiency of granulocyte colony-stimulating factor and stem cell factor to bone marrow mononuclear cells and mechanisms.
SDF-1alpha played a crucial role in the intimal hyperplasia after carotid artery injury.
Title: Role of stromal-derived factor-1<alpha>/CXCR4 in neo-intimal repair.

Submit: New GeneRIF Correction See all (221)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (2) 1 citation
Targeted (knock-out) (1) 1 citation
Targeted (other) (1) 1 citation
Targeted (Reporter) (1) 1 citation
Targeted (knock-in) (1) 1 citation

Pathways from BioSystems

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Axon guidance, organism-specific biosystem (from KEGG)
Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, conserved biosystem (from KEGG)
Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
Chemokine receptors bind chemokines, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
Intestinal immune network for IgA production, conserved biosystem (from KEGG)
Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
Leukocyte transendothelial migration, conserved biosystem (from KEGG)
Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
Nuclear signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Rheumatoid arthritis, conserved biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB4, organism-specific biosystem (from REACTOME)
Signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

Sdf1 (e-PCR), detects polymorphism
- UniSTS:144384

Sdf1 (e-PCR), detects polymorphism
- UniSTS:144385

NoName (e-PCR)
- UniSTS:235532

L12030 (e-PCR)
- UniSTS:159562

Cxcl12 (e-PCR), detects polymorphism
- UniSTS:470615

Cxcl12 (e-PCR), detects polymorphism
- UniSTS:525662

Cxcl12 (e-PCR), detects polymorphism
- UniSTS:525663

Cxcl12 (e-PCR), detects polymorphism
- UniSTS:502723

Cxcl12 (e-PCR), detects polymorphism
- UniSTS:506829

AI174028 (e-PCR)
- UniSTS:179445

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
CXCR chemokine receptor binding	ISO Inferred from Sequence Orthology more info
chemokine activity	IDA Inferred from Direct Assay more info	PubMed
cytokine activity	IEA Inferred from Electronic Annotation more info
growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
adult locomotory behavior	ISO Inferred from Sequence Orthology more info
ameboidal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
brain development	IDA Inferred from Direct Assay more info	PubMed
chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
chemotaxis	IEA Inferred from Electronic Annotation more info
germ cell development	IDA Inferred from Direct Assay more info	PubMed
germ cell migration	IDA Inferred from Direct Assay more info	PubMed
immune response	IEA Inferred from Electronic Annotation more info
induction of positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of leukocyte apoptotic process	ISO Inferred from Sequence Orthology more info
neuron migration	ISO Inferred from Sequence Orthology more info
organ regeneration	ISO Inferred from Sequence Orthology more info
patterning of blood vessels	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
telencephalon cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	ISO Inferred from Sequence Orthology more info
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stromal cell-derived factor 1

Names: stromal cell-derived factor 1; pre-B-cell growth-stimulating factor; thymic lymphoma cell-stimulating factor; 12-O-tetradecanoylphorbol 13-acetate repressed protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012477.2 → NP_001012495.1 stromal cell-derived factor 1 isoform gamma precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (gamma).

Source sequence(s)

AC155646, BC046827

Consensus CDS

CCDS20463.1

UniProtKB/TrEMBL

H7BX38

Related

ENSMUSP00000072800, OTTMUSP00000026114, ENSMUST00000073043, OTTMUST00000054664

Conserved Domains (1) summary

cd00273
Location:27 – 88
Blast Score: 128

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...
NM_013655.4 → NP_038683.1 stromal cell-derived factor 1 isoform beta precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 3. The resulting isoform (beta) is shorter and has a distinct C-terminus compared to isoform gamma.

Source sequence(s)

AC155646, BB840704

Consensus CDS

CCDS39605.1

UniProtKB/Swiss-Prot

P40224

Related

ENSMUSP00000108492, OTTMUSP00000026113, ENSMUST00000112871, OTTMUST00000054663

Conserved Domains (1) summary

cd00273
Location:27 – 88
Blast Score: 127

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...
NM_021704.3 → NP_068350.1 stromal cell-derived factor 1 isoform alpha precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 3' UTR and 3' coding region compared to variant 3. The resulting isoform (alpha) is shorter at the C-terminus, compared to isoform gamma.

Source sequence(s)

AC155646, AK045092

Consensus CDS

CCDS39606.1

UniProtKB/Swiss-Prot

P40224

Related

ENSMUSP00000108487, OTTMUSP00000026112, ENSMUST00000112866, OTTMUST00000054662

Conserved Domains (1) summary

cd00273
Location:27 – 88
Blast Score: 127

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000072.6 Reference GRCm38.p1 C57BL/6J

Range

117168535..117181368

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000028.1 Alternate Mm_Celera

Range

118991272..119004105

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01056844.1 (11843..24676)	None
genomic	AC155646.4 (113302..126135)	None
genomic	CAAA01066961.1	None
genomic	CH466523.1	EDK99571.1	mixed
		EDK99572.1	mixed
		EDK99573.1	mixed
mRNA	AK045092.1	BAC32216.1	C57BL/6J
mRNA	AK075596.1	BAC35845.1	C57BL/6J
mRNA	AK157553.1	BAE34120.1	NOD
mRNA	BB610070.1	None	C57BL/6J
mRNA	BB840704.1	None	C57BL/6J
mRNA	BC006640.1	AAH06640.1
mRNA	BC020297.1	None	FVB/N
mRNA	BC029335.1	None
mRNA	BC046827.1	None	C57BL/6
mRNA	CT010389.1	CAJ18596.1
mRNA	D21072.1	BAA04648.1
mRNA	D43804.1	BAA07862.1	AKR/J
mRNA	D43805.1	BAA07863.1	AKR/J
mRNA	L12029.1	AAA40100.1
mRNA	L12030.1	AAA40101.1
mRNA	S74318.1	AAB32650.1