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HTRA4 HtrA serine peptidase 4 [ Homo sapiens (human) ]

Gene ID: 203100, updated on 4-Jul-2015
Official Symbol
HTRA4provided by HGNC
Official Full Name
HtrA serine peptidase 4provided by HGNC
Primary source
HGNC:HGNC:26909
See related
Ensembl:ENSG00000169495; HPRD:08818; MIM:610700; Vega:OTTHUMG00000164070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
Orthologs
See HTRA4 in Epigenomics, MapViewer
Location:
8p11.22
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (38974149..38988662)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38831668..38846181)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene transforming, acidic coiled-coil containing protein 1 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 Neighboring gene TM2 domain containing 2 Neighboring gene ADAM metallopeptidase domain 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • FLJ90724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
serine protease HTRA4
Names
high-temperature requirement factor A4
probable serine protease HTRA4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153692.3NP_710159.1  serine protease HTRA4 precursor

    See identical proteins and their annotated locations for NP_710159.1

    Status: REVIEWED

    Source sequence(s)
    AC108863, AK075205, AY188774, DC423042
    Consensus CDS
    CCDS6110.1
    UniProtKB/Swiss-Prot
    P83105
    Related
    ENSP00000305919, OTTHUMP00000225766, ENST00000302495, OTTHUMT00000377077
    Conserved Domains (5) summary
    smart00121
    Location:4094
    IB; Insulin growth factor-binding protein homologues
    COG0265
    Location:156470
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00104
    Location:108152
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00987
    Location:380470
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam13365
    Location:202340
    Trypsin_2; Trypsin-like peptidase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    38974149..38988662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544430.1XP_011542732.1  

    Conserved Domains (5) summary
    smart00121
    Location:4094
    IB; Insulin growth factor-binding protein homologues
    COG0265
    Location:156438
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00104
    Location:108152
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00987
    Location:348438
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam13365
    Location:194308
    Trypsin_2; Trypsin-like peptidase domain
  2. XM_011544431.1XP_011542733.1  

    Conserved Domains (3) summary
    smart00121
    Location:4094
    IB; Insulin growth factor-binding protein homologues
    cd00104
    Location:108152
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam13365
    Location:202340
    Trypsin_2; Trypsin-like peptidase domain
  3. XM_011544432.1XP_011542734.1  

    Conserved Domains (3) summary
    smart00121
    Location:4094
    IB; Insulin growth factor-binding protein homologues
    cd00104
    Location:108152
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam13365
    Location:202332
    Trypsin_2; Trypsin-like peptidase domain

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    39033728..39048258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)