Il8 interleukin 8 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Il8provided by MGI
Official Full Name: interleukin 8provided by MGI
Primary source: MGI:1339941
See related: Ensembl:ENSMUSG00000029375
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: weche; Cxcl15; Scyb15; lungkine

Genomic context

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Location :: 5 E1; 5 44.78 cM

Sequence :: Chromosome: 5; NC_000071.6 (90794534..90803067)

See Il8 in Epigenomics, MapViewer

Chromosome 5 - NC_000071.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

ExoU activates NF-kappaB, stimulating IL-8 expression and secretion during P. aeruginosa infection
Title: ExoU activates NF-κB and increases IL-8/KC secretion during Pseudomonas aeruginosa infection.
Met signaling regulates the secretion of the pro-angiogenic chemokine interleukin-8/CXCL8
Title: Met receptor tyrosine kinase signaling induces secretion of the angiogenic chemokine interleukin-8/CXCL8 in pancreatic cancer.

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

Pathways from BioSystems

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Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...

General gene information

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Markers

Cxcl15 (e-PCR), detects polymorphism
- UniSTS:528219

Homology

OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
chemokine activity	IDA Inferred from Direct Assay more info	PubMed
cytokine activity	IEA Inferred from Electronic Annotation more info
interleukin-8 receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
cell cycle arrest	ISO Inferred from Sequence Orthology more info
cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
chemotaxis	IDA Inferred from Direct Assay more info	PubMed
hemopoiesis	IDA Inferred from Direct Assay more info	PubMed
immune response	IEA Inferred from Electronic Annotation more info
induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
inflammatory response	IDA Inferred from Direct Assay more info	PubMed
intracellular signal transduction	ISO Inferred from Sequence Orthology more info
negative regulation of G-protein coupled receptor protein signaling pathway	ISO Inferred from Sequence Orthology more info
neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
receptor internalization	ISO Inferred from Sequence Orthology more info
regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
regulation of retroviral genome replication	ISO Inferred from Sequence Orthology more info
response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
response to molecule of bacterial origin	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
extracellular region	IDA Inferred from Direct Assay more info	PubMed
extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C motif chemokine 15

Names: C-X-C motif chemokine 15; small-inducible cytokine B15; chemokine (C-X-C motif) ligand 15; small inducible cytokine subfamily B, member 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011339.2 → NP_035469.1 C-X-C motif chemokine 15 precursor

Status: VALIDATED

Source sequence(s)

AK142955

Consensus CDS

CCDS19418.1

UniProtKB/TrEMBL

Q3UQ15

UniProtKB/Swiss-Prot

Q9WVL7

Related

ENSMUSP00000031322, ENSMUST00000031322

Conserved Domains (1) summary

cd00273
Location:27 – 90
Blast Score: 209

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 129S1/SvImJ

Genomic

NT_109599.1 Reference GRCm38.p1 129S1/SvImJ

Range

23698..32212, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000071.6 Reference GRCm38.p1 C57BL/6J

Range

90794534..90803067

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000027.1 Alternate Mm_Celera

Range

88946158..88954669

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01046746.1 (8608..17119)	None
genomic	AC105995.9 (116396..123713)	None
genomic	AC113262.29 (24870..32174)	None	129/Sv
genomic	CH466617.2	EDL05302.1	mixed
mRNA	AF082859.1	AAD38079.1
mRNA	AK019412.2	None	C57BL/6J
mRNA	AK142955.1	BAE25229.1	C57BL/6J
mRNA	BC061138.1	AAH61138.1