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    Ccl27a chemokine (C-C motif) ligand 27A [ Mus musculus (house mouse) ]

    Gene ID: 20301, updated on 18-May-2013
    Official Symbol
    Ccl27aprovided by MGI
    Official Full Name
    chemokine (C-C motif) ligand 27Aprovided by MGI
    Primary source
    MGI:1343459
    Locus tag
    RP23-167I12.8
    See related
    Ensembl:ENSMUSG00000073888; Vega:OTTMUSG00000006697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ALP; ILC; CTAK; CTACK; Ccl27; PESKY; ESkine; Scya27; Scya27a; AW558992
    Location :
    4 A5; 4 22.08 cM
    Sequence :
    Chromosome: 4; NC_000070.6 (41769467..41774176, complement)
    See Ccl27a in Epigenomics, MapViewer

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene sigma non-opioid intracellular receptor 1 Neighboring gene galactose-1-phosphate uridyl transferase Neighboring gene interleukin 11 receptor, alpha chain 1 Neighboring gene predicted gene 12407 Neighboring gene predicted pseudogene 10601

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    2. Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation. Valerius MT, et al. Gene Expr Patterns, 2008 May. PMID 18346943.
    3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559.
    4. CCL27-transgenic mice show enhanced contact hypersensitivity to Th2, but not Th1 stimuli. Kagami S, et al. Eur J Immunol, 2008 Mar. PMID 18266301.
    5. Tumor immune escape by the loss of homeostatic chemokine expression. Pivarcsi A, et al. Proc Natl Acad Sci U S A, 2007 Nov 27. PMID 18025475.

    See all (27) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results indicated that CCL27 modified inflammation by attracting CCR10-positive and CCR4-positive cells into the lesional skin, and may participate in the pathogenesis of Th2-shifted skin diseases such as atopic dermatitis.
      Title: CCL27-transgenic mice show enhanced contact hypersensitivity to Th2, but not Th1 stimuli.
    2. In mice, neutralization of CCL27 led to decreased leukocyte recruitment to cutaneous tumor sites and significantly enhanced primary tumor growth.
      Title: Tumor immune escape by the loss of homeostatic chemokine expression.
    3. We investigated the role of CCL27, a T cell skin-homing chemokine known to be elevated in sera of human AD patients, in disease development in our animal model of atopic dermatitis.
      Title: CCL27 is a critical factor for the development of atopic dermatitis in the keratin-14 IL-4 transgenic mouse model.
    4. LIGHT stimulation enhances CCL27 expression through activation of NF-kappaB in DCs.
      Title: TNF family molecule LIGHT regulates chemokine CCL27 expression on mouse embryonic stem cell-derived dendritic cells through NF-kappaB activation.
    Submit: New GeneRIF Correction
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC130150

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    Preferred Names
    C-C motif chemokine 27
    Names
    C-C motif chemokine 27
    skinkine
    skinskine
    CC chemokine ILC
    small inducible cytokine A27
    small-inducible cytokine A27
    IL-11 R-alpha-locus chemokine
    small inducible cytokine A27a
    chemokine (C-C motif) ligand 27
    cutaneous T-cell-attracting chemokine

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048179.1 → NP_001041644.1  C-C motif chemokine 27 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      CA451425
      Consensus CDS
      CCDS38721.1
      UniProtKB/TrEMBL
      A2AMS7
      Related
      ENSMUSP00000103672, OTTMUSP00000007096, ENSMUST00000108037, OTTMUST00000015389
      Conserved Domains (1) summary
      pfam00048
      Location:73 – 136
      Blast Score: 113
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    2. NM_001164044.1 → NP_001157516.1  C-C motif chemokine 27 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AK005753, AL807796
      Consensus CDS
      CCDS51144.1
      UniProtKB/TrEMBL
      A2AMS8

    3. NM_001164045.1 → NP_001157517.1  C-C motif chemokine 27 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AL807796, BC099574
      Consensus CDS
      CCDS51144.1
      UniProtKB/TrEMBL
      A2AMS8
      Related
      ENSMUSP00000133827, ENSMUST00000173865

    4. NM_011336.1 → NP_035466.1  C-C motif chemokine 27 isoform 2 precursor

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB013398
      Consensus CDS
      CCDS18072.1
      UniProtKB/Swiss-Prot
      Q9Z1X0
      Related
      ENSMUSP00000073990, ENSMUST00000074387
      Conserved Domains (1) summary
      pfam00048
      Location:32 – 92
      Blast Score: 107
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p1 C57BL/6J

      Range
      41769467..41774176, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AL807796.17 (125894..130762) None
    genomic CH466538.2 EDL05374.1 mixed
      EDL05375.1 mixed
      EDL05376.1 mixed
      EDL05377.1 mixed
      EDL05378.1 mixed
      EDL05379.1 mixed
      EDL05381.1 mixed
      EDL05382.1 mixed
    genomic CQ813009.1 CAG29884.1
    mRNA AB013398.1 BAA88474.1
    mRNA AF082392.1 AAD41237.1
    mRNA AF099931.1 AAD04163.1
    mRNA AK005398.1 BAB24001.1 C57BL/6J
    mRNA AK005753.1 None C57BL/6J
    mRNA AK146066.1 None C57BL/6J
    mRNA BC099574.1 None
    mRNA BC107226.2 AAI07227.1
    mRNA CA451425.1 None C57BL/6
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1X0.2 GenPept UniProtKB/Swiss-Prot:Q9Z1X0

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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