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Msr1 macrophage scavenger receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 20288, updated on 8-May-2016
Official Symbol
Msr1provided by MGI
Official Full Name
macrophage scavenger receptor 1provided by MGI
Primary source
MGI:MGI:98257
See related
Ensembl:ENSMUSG00000025044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MSR; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1
Orthologs
Location:
8 A4; 8 23.89 cM
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (39543232..39642751, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (40667054..40728032, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene 6213 Neighboring gene voltage-dependent anion channel 3 pseudogene Neighboring gene copine VIII pseudogene Neighboring gene predicted gene, 36741 Neighboring gene predicted gene 2033 Neighboring gene predicted gene, 36795

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
low-density lipoprotein particle binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cholesterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cholesterol storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macrophage derived foam cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
macrophage scavenger receptor types I and II
Names
SR-A
macrophage acetylated LDL receptor I and II
scavenger receptor type A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113326.1NP_001106797.1  macrophage scavenger receptor types I and II isoform b

    See identical proteins and their annotated locations for NP_001106797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes alternate exons in the 5' coding region, compared to variant 1. The resulting protein (isoform b) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AF203781, AK150518
    Consensus CDS
    CCDS52542.1
    UniProtKB/Swiss-Prot
    P30204
    UniProtKB/TrEMBL
    Q8CED7
    Related
    ENSMUSP00000026021, ENSMUST00000026021
    Conserved Domains (6) summary
    pfam01391
    Location:277338
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:357457
    SR; Scavenger receptor Cys-rich
    COG0840
    Location:118275
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    pfam03523
    Location:125173
    Macscav_rec; Macrophage scavenger receptor
    pfam05615
    Location:154253
    THOC7; Tho complex subunit 7
    pfam15240
    Location:276342
    Pro-rich; Proline-rich
  2. NM_031195.2NP_112472.2  macrophage scavenger receptor types I and II isoform a

    See identical proteins and their annotated locations for NP_112472.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (a).
    Source sequence(s)
    AC111028, AK151855, AK155589
    Consensus CDS
    CCDS52543.1
    UniProtKB/TrEMBL
    Q8CED7
    Related
    ENSMUSP00000132535, ENSMUST00000170091
    Conserved Domains (5) summary
    pfam01391
    Location:277338
    Collagen; Collagen triple helix repeat (20 copies)
    COG0840
    Location:118275
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    pfam03523
    Location:125173
    Macscav_rec; Macrophage scavenger receptor
    pfam05615
    Location:154253
    THOC7; Tho complex subunit 7
    pfam15240
    Location:276342
    Pro-rich; Proline-rich

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    39543232..39642751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509311.2XP_006509374.1  

    Conserved Domains (5) summary
    pfam01391
    Location:306367
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:386443
    SR; Scavenger receptor Cys-rich
    COG0840
    Location:147304
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    pfam03523
    Location:154202
    Macscav_rec; Macrophage scavenger receptor
    pfam05615
    Location:183282
    THOC7; Tho complex subunit 7
  2. XM_006509312.2XP_006509375.1  

    Conserved Domains (6) summary
    pfam01391
    Location:273334
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:353453
    SR; Scavenger receptor Cys-rich
    COG0840
    Location:114271
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    pfam03523
    Location:121169
    Macscav_rec; Macrophage scavenger receptor
    pfam05615
    Location:150249
    THOC7; Tho complex subunit 7
    pfam15240
    Location:272338
    Pro-rich; Proline-rich

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    42254529..42315500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)