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Scnn1a sodium channel, nonvoltage-gated 1 alpha [ Mus musculus (house mouse) ]

Gene ID: 20276, updated on 8-May-2016
Official Symbol
Scnn1aprovided by MGI
Official Full Name
sodium channel, nonvoltage-gated 1 alphaprovided by MGI
Primary source
MGI:MGI:101782
See related
Ensembl:ENSMUSG00000030340 Vega:OTTMUSG00000038566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ENaC; SCNEA; Scnn1; mENaC
Orthologs
Location:
6 F3; 6 59.32 cM
Exon count:
12
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (125321340..125344943)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (125271358..125294961)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene lymphotoxin B receptor Neighboring gene predicted gene, 38897 Neighboring gene tumor necrosis factor receptor superfamily, member 1a Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
WW domain binding ISO
Inferred from Sequence Orthology
more info
 
actin binding ISO
Inferred from Sequence Orthology
more info
 
ligand-gated sodium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
ligand-gated sodium channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
ligand-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to ligand-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to sodium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ion transport IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal water homeostasis ISO
Inferred from Sequence Orthology
more info
 
regulation of body fluid levels ISO
Inferred from Sequence Orthology
more info
 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
sensory perception of taste IEA
Inferred from Electronic Annotation
more info
 
sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
ciliary membrane ISO
Inferred from Sequence Orthology
more info
 
cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
motile cilium ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
sodium channel complex IGI
Inferred from Genetic Interaction
more info
PubMed 
sodium channel complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
amiloride-sensitive sodium channel subunit alpha
Names
ENaC alpha
alpha-ENaC
alpha-NaCH
amiloride-sensitive epithelial sodium channel
epithelial Na(+) channel subunit alpha
epithelial sodium channel alpha subunit
nonvoltage-gated sodium channel 1 subunit alpha
sodium channel, nonvoltage-gated, type I, alpha polypeptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011324.2NP_035454.2  amiloride-sensitive sodium channel subunit alpha

    See identical proteins and their annotated locations for NP_035454.2

    Status: VALIDATED

    Source sequence(s)
    AC140324, AF112185, AK140389
    Consensus CDS
    CCDS39641.2
    UniProtKB/Swiss-Prot
    Q61180
    UniProtKB/TrEMBL
    Q3USG4
    Related
    ENSMUSP00000080164, OTTMUSP00000055834, ENSMUST00000081440, OTTMUST00000099477
    Conserved Domains (2) summary
    TIGR00859
    Location:80677
    ENaC; sodium channel transporter
    TIGR00867
    Location:88600
    deg-1; degenerin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    125321340..125344943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    126992384..127015966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)