Ryk receptor-like tyrosine kinase [Mus musculus] - Gene

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Summary

Official Symbol: Rykprovided by MGI
Official Full Name: receptor-like tyrosine kinaseprovided by MGI
Primary source: MGI:101766
See related: Ensembl:ENSMUSG00000032547
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vik; ERK-3; AW536699

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Genomic context

Location :: 9 F1; 9 61.0 cM

Sequence :: Chromosome: 9; NC_000075.6 (102834920..102908307)

See Ryk in Epigenomics, MapViewer

Chromosome 9 - NC_000075.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results identify Ryk as a multi-functional receptor that is able to transduce extrinsic cues into progenitor cells, promote GABAergic neuron formation, and inhibit oligodendrogenesis during ventral embryonic brain development.
Title: The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development.
Results demonstrate an unexpected mechanism of Ryk as a Wnt receptor, where the intracellular domain itself functions as the transducing molecule to bring signals from the cell surface into the nucleus, to regulate neural cell differentiation.
Title: Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis.
Wnt3 repulsion is mediated by Ryk, expressed in a ventral-to-dorsal decreasing gradient
Title: Wnt-Ryk signalling mediates medial-lateral retinotectal topographic mapping.
summary, this study expands the emerging role for Wnts in axon guidance and identifies Ryk as a key guidance receptor in the establishment of the corpus callosum.
Title: The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum.
Mammalian Ryk, unlike the Drosophila Ryk homolog Derailed, functions as a coreceptor along with Frizzled for Wnt ligands.
Title: Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.
RYK regulates cell migration during mammalian cortical development through the binding to Eph receptors
Title: Receptor related to tyrosine kinase RYK regulates cell migration during cortical development.

Submit: New GeneRIF Correction

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Reporter) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:203044	BioGRID:198626	Cdc37	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:203044	BioGRID:199342	Dvl1	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Enhancement
BioGRID:203044	BioGRID:199781	Fzd8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203044	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203044	BioGRID:204567	Wnt1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203044	BioGRID:204575	Wnt3a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:203044	BioGRID:204577	Wnt5a	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
Wnt-activated receptor activity	IPI Inferred from Physical Interaction more info	PubMed
Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	IEA Inferred from Electronic Annotation more info
NOT protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
Wnt receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
Wnt receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
axon guidance	IDA Inferred from Direct Assay more info	PubMed
axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
commissural neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
corpus callosum development	IMP Inferred from Mutant Phenotype more info	PubMed
negative chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info
signal transduction	IEA Inferred from Electronic Annotation more info
skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IDA Inferred from Direct Assay more info	PubMed
membrane fraction	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: tyrosine-protein kinase RYK

Names: tyrosine-protein kinase RYK; NYK-R; kinase VIK; met-related kinase; growth factor receptor

NP_001036072.1

EC 2.7.10.1

NP_038677.3

EC 2.7.10.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042607.1 → NP_001036072.1 tyrosine-protein kinase RYK isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AK144355, BB704205, L02210, L21707

UniProtKB/Swiss-Prot

Q01887

Conserved Domains (3) summary

cd05043
Location:307 – 587
Blast Score: 1456

PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)

cl02623
Location:51 – 180
Blast Score: 522

WIF; WIF domain

pfam07714
Location:314 – 580
Blast Score: 880

Pkinase_Tyr; Protein tyrosine kinase
NM_013649.3 → NP_038677.3 tyrosine-protein kinase RYK isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AK076449, AK144355, BB704205, L02210, L21707

Consensus CDS

CCDS40747.1

UniProtKB/Swiss-Prot

Q01887

Related

ENSMUSP00000035142, ENSMUST00000035142

Conserved Domains (3) summary

cd05043
Location:310 – 590
Blast Score: 1457

PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)

cl02623
Location:51 – 180
Blast Score: 522

WIF; WIF domain

pfam07714
Location:317 – 583
Blast Score: 881

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000075.6 Reference GRCm38 C57BL/6J

Range

102834920..102908307

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000031.1 Alternate Mm_Celera

Range

102375302..102457932

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC164161.2 (9135..81674)	None
genomic	AF080624.1	AAC29495.1	129/SvJ
mRNA	AK076449.1	None	C57BL/6J
mRNA	AK144355.1	None	C57BL/6J
mRNA	BB704205.1	None	C57BL/6J
mRNA	BC006963.1	AAH06963.1	FVB/N
mRNA	BC032275.1	AAH32275.1	FVB/N-3
mRNA	L02210.1	AAA40579.1
mRNA	L10915.1	None	129/Sv
mRNA	L21707.1	AAA02913.1
mRNA	L38394.1	AAA67060.1
mRNA	M98547.1	AAA40079.1	BALB/c
mRNA	S52036.1	AAB24703.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q01887.2	GenPept	UniProtKB/Swiss-Prot:Q01887
Q71UK0	GenPept	UniProtKB/TrEMBL:Q71UK0
Q8K272	GenPept	UniProtKB/TrEMBL:Q8K272