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Ncor1 nuclear receptor co-repressor 1 [ Mus musculus (house mouse) ]

Gene ID: 20185, updated on 28-May-2016
Official Symbol
Ncor1provided by MGI
Official Full Name
nuclear receptor co-repressor 1provided by MGI
Primary source
MGI:MGI:1349717
See related
Ensembl:ENSMUSG00000018501 Vega:OTTMUSG00000005855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N-CoR; RIP13; Rxrip13; mKIAA1047; 5730405M06Rik; A230020K14Rik
Orthologs
Location:
11; 11 B2
Exon count:
49
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (62315643..62457332, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (62130192..62270834, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene adenosine A2b receptor Neighboring gene zinc finger SWIM-type containing 7 Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene predicted gene, 39989 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class L Neighboring gene centromere protein V

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ligand-dependent nuclear receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
nuclear hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
retinoic acid receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
 
retinoid X receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
thyroid hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to Thyroglobulin triiodothyronine IGI
Inferred from Genetic Interaction
more info
PubMed 
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
circadian regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
definitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of thyroid hormone mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
spindle assembly ISO
Inferred from Sequence Orthology
more info
 
thalamus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Sin3 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with Sin3 complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IPI
Inferred from Physical Interaction
more info
PubMed 
transcriptional repressor complex IPI
Inferred from Physical Interaction
more info
PubMed 
transcriptional repressor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
nuclear receptor corepressor 1
Names
N-CoR1
retinoid X receptor interacting protein 13
retinoid X receptor-interacting protein 13

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252313.1NP_001239242.1  nuclear receptor corepressor 1 isoform 1

    See identical proteins and their annotated locations for NP_001239242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL596110, BX248411
    Consensus CDS
    CCDS56781.1
    UniProtKB/TrEMBL
    Q5RIM6
    Related
    ENSMUSP00000098627, ENSMUST00000101066
    Conserved Domains (4) summary
    pfam05432
    Location:666895
    BSP_II; Bone sialoprotein II (BSP-II)
    smart00717
    Location:627672
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:627670
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam14962
    Location:713810
    AIF-MLS; Mitochondria Localisation Sequence
  2. NM_011308.3NP_035438.3  nuclear receptor corepressor 1 isoform 2

    See identical proteins and their annotated locations for NP_035438.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB093281, AK077420, BC086657, BU504661
    UniProtKB/TrEMBL
    Q5PRE9, Q8BK32, Q8CHB6
    Related
    ENSMUSP00000098628, OTTMUSP00000047847, ENSMUST00000101067, OTTMUST00000087854
    Conserved Domains (2) summary
    smart00717
    Location:627672
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:627670
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  3. NM_177229.3NP_796203.1  nuclear receptor corepressor 1 isoform 3

    See identical proteins and their annotated locations for NP_796203.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (3) is much shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK035813, AK077420, BB140234, BB673294
    Consensus CDS
    CCDS56782.1
    UniProtKB/TrEMBL
    Q8BK32
    Related
    ENSMUSP00000068974, OTTMUSP00000006061, ENSMUST00000069456, OTTMUST00000013030

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    62315643..62457332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248830.1XP_011247132.1  

    See identical proteins and their annotated locations for XP_011247132.1

    Conserved Domains (3) summary
    smart00717
    Location:637682
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:637680
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam14962
    Location:729826
    AIF-MLS; Mitochondria Localisation Sequence
  2. XM_006532625.2XP_006532688.1  

    Conserved Domains (3) summary
    pfam05432
    Location:666862
    BSP_II; Bone sialoprotein II (BSP-II)
    smart00717
    Location:627672
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:627670
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  3. XM_006532624.2XP_006532687.1  

    See identical proteins and their annotated locations for XP_006532687.1

    UniProtKB/TrEMBL
    Q5RIM6
    Related
    ENSMUSP00000018645, OTTMUSP00000006054, ENSMUST00000018645, OTTMUST00000013021
    Conserved Domains (4) summary
    pfam05432
    Location:666895
    BSP_II; Bone sialoprotein II (BSP-II)
    smart00717
    Location:627672
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:627670
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam14962
    Location:713810
    AIF-MLS; Mitochondria Localisation Sequence
  4. XM_006532628.2XP_006532691.1  

    Conserved Domains (3) summary
    pfam05432
    Location:666895
    BSP_II; Bone sialoprotein II (BSP-II)
    smart00717
    Location:627672
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:627670
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  5. XM_006532623.2XP_006532686.1  

    Conserved Domains (4) summary
    pfam05432
    Location:666895
    BSP_II; Bone sialoprotein II (BSP-II)
    smart00717
    Location:627672
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:627670
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam14962
    Location:713810
    AIF-MLS; Mitochondria Localisation Sequence
  6. XM_006532627.2XP_006532690.1  

    Conserved Domains (2) summary
    smart00717
    Location:627672
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:627670
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  7. XM_006532619.2XP_006532682.1  

    Conserved Domains (3) summary
    smart00717
    Location:627672
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:627670
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam14962
    Location:719816
    AIF-MLS; Mitochondria Localisation Sequence
  8. XM_006532618.2XP_006532681.1  

    Conserved Domains (3) summary
    pfam05432
    Location:675904
    BSP_II; Bone sialoprotein II (BSP-II)
    smart00717
    Location:636681
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:636679
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  9. XM_006532620.2XP_006532683.1  

    Conserved Domains (2) summary
    smart00717
    Location:636681
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:636679
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  10. XM_006532613.2XP_006532676.1  

    Conserved Domains (3) summary
    smart00717
    Location:636681
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:636679
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam14962
    Location:728825
    AIF-MLS; Mitochondria Localisation Sequence
  11. XM_006532621.2XP_006532684.1  

    Conserved Domains (3) summary
    smart00717
    Location:637682
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:637680
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam14962
    Location:729826
    AIF-MLS; Mitochondria Localisation Sequence
  12. XM_006532616.2XP_006532679.1  

    Conserved Domains (3) summary
    smart00717
    Location:637682
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:637680
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam14962
    Location:729826
    AIF-MLS; Mitochondria Localisation Sequence
  13. XM_006532626.2XP_006532689.1  

    Conserved Domains (3) summary
    smart00717
    Location:637682
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:637680
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam14962
    Location:729826
    AIF-MLS; Mitochondria Localisation Sequence
  14. XM_006532614.2XP_006532677.1  

    Conserved Domains (3) summary
    smart00717
    Location:637682
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:637680
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam14962
    Location:729826
    AIF-MLS; Mitochondria Localisation Sequence
  15. XM_006532615.2XP_006532678.1  

    Conserved Domains (3) summary
    smart00717
    Location:637682
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:637680
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam14962
    Location:729826
    AIF-MLS; Mitochondria Localisation Sequence
  16. XM_011248831.1XP_011247133.1  

    See identical proteins and their annotated locations for XP_011247133.1

    Conserved Domains (3) summary
    smart00717
    Location:637682
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:637680
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam14962
    Location:729826
    AIF-MLS; Mitochondria Localisation Sequence

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    69235347..69376529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)