These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_029881.1 RefSeqGene
- Range
- 5001..43079
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001184740.1 → NP_001171669.1 src substrate cortactin isoform c
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) uses different splice sites in the 3' coding region, which changes reading frame and the termination stop codon, compared to variant 1. The resulting protein (isoform c) has a longer and distinct C-terminus when it is compared to isoform a.
- Source sequence(s)
-
AA325227, BC008799, BC033889, DA716772
- Consensus CDS
-
CCDS53676.1
- Related
- ENSP00000365745, OTTHUMP00000235667, ENST00000376561, OTTHUMT00000394097
- Conserved Domains (2) summary
-
- cd00174
Location:459 – 499
Blast Score: 148
- SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
- pfam02218
Location:157 – 193
Blast Score: 182
- HS1_rep; Repeat in HS1/Cortactin
-
NM_005231.3 → NP_005222.2 src substrate cortactin isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) is the longest transcript.
- Source sequence(s)
-
AK222613, AK291097, BC008799, DA716772
- Consensus CDS
-
CCDS41680.1
- UniProtKB/Swiss-Prot
-
Q14247
- UniProtKB/TrEMBL
-
Q53HG7
- Related
- ENSP00000301843, OTTHUMP00000165962, ENST00000301843, OTTHUMT00000259233
- Conserved Domains (2) summary
-
- cd00174
Location:496 – 548
Blast Score: 184
- SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
- pfam02218
Location:157 – 193
Blast Score: 168
- HS1_rep; Repeat in HS1/Cortactin
-
NM_138565.2 → NP_612632.1 src substrate cortactin isoform b
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an internal segment of sequence, compared to variant 1. The resulting protein (isoform b) has the same N- and C- termini but is shorter when it is compared to isoform a.
- Source sequence(s)
-
AK222613, BC008799, DA716772
- Consensus CDS
-
CCDS8197.1
- UniProtKB/TrEMBL
-
Q53HG7
- Related
- ENSP00000317189, OTTHUMP00000165961, ENST00000346329, OTTHUMT00000259232
- Conserved Domains (2) summary
-
- cd00174
Location:459 – 511
Blast Score: 184
- SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
- pfam02218
Location:157 – 193
Blast Score: 171
- HS1_rep; Repeat in HS1/Cortactin
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000011.9 Reference GRCh37.p5 Primary Assembly
- Range
- 70244612..70282690
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000143.1 Alternate HuRef
- Range
- 66505811..66543873
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)