Rrm1 ribonucleotide reductase M1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Rrm1provided by MGI
Official Full Name: ribonucleotide reductase M1provided by MGI
Primary source: MGI:98180
See related: Ensembl:ENSMUSG00000030978
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RnrM1

Genomic context

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Location :: 7 E3; 7 54.72 cM

Sequence :: Chromosome: 7; NC_000073.6 (102441695..102469771)

See Rrm1 in Epigenomics, MapViewer

Chromosome 7 - NC_000073.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

silencing RRM1 expression using siRNA could potentially be an effective strategy to overcome gemcitabine resistance.
Title: Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells.
Tip60-dependent recruitment of RNR plays an essential role in dNTP supply for DNA repair
Title: Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase.
overexpression of RRM1 in human and mouse lung cancer cell lines induced PTEN expression, reduced phosphorylation of focal adhesion kinase (FAK), suppressed migration, invasion, and metastasis formation, and increased survival in an animal model.
Title: RRM1-induced metastasis suppression through PTEN-regulated pathways.
The hexamer form of murine ribonucleotide reductase (mRR) large catalytic subunit mR1(6) predominates over the dimer form mR1(2) in the cytoplasm of normal cells, where the great majority of mRR activity is located.
Title: Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: refinements and consequences.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:203022	BioGRID:219884	Kat5		BioGRID	PubMed	Reconstituted Complex
BioGRID:203022	BioGRID:203023	Rrm2		BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Glutathione metabolism, organism-specific biosystem (from KEGG)
Glutathione metabolism, organism-specific biosystem
Glutathione metabolism
Glutathione metabolism, conserved biosystem (from KEGG)
Glutathione metabolism, conserved biosystem
Glutathione metabolism
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of nucleotides, organism-specific biosystem (from REACTOME)
Metabolism of nucleotides, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide Metabolism, organism-specific biosystem (from WikiPathways)
Nucleotide Metabolism, organism-specific biosystem
Nucleotide Metabolism
Purine metabolism, organism-specific biosystem (from KEGG)
Purine metabolism, organism-specific biosystem
Purine metabolism
Purine metabolism, organism-specific biosystem (from WikiPathways)
Purine metabolism, organism-specific biosystem
Purine metabolism
Purine metabolism, conserved biosystem (from KEGG)
Purine metabolism, conserved biosystem
Purine metabolism
Pyrimidine metabolism, organism-specific biosystem (from KEGG)
Pyrimidine metabolism, organism-specific biosystem
Pyrimidine metabolism
Pyrimidine metabolism, conserved biosystem (from KEGG)
Pyrimidine metabolism, conserved biosystem
Pyrimidine metabolism
Synthesis and interconversion of nucleotide di- and triphosphates, organism-specific biosystem (from REACTOME)
Synthesis and interconversion of nucleotide di- and triphosphates, organism-specific biosystemcomputationally inferred pathway (not manually curated)
adenosine nucleotides de novo biosynthesis, organism-specific biosystem (from BIOCYC)
adenosine nucleotides de novo biosynthesis, organism-specific biosystem
adenosine nucleotides de novo biosynthesis
pyrimidine deoxyribonucleotides de novo biosynthesis I, organism-specific biosystem (from BIOCYC)
pyrimidine deoxyribonucleotides de novo biosynthesis I, organism-specific biosystem
pyrimidine deoxyribonucleotides de novo biosynthesis I

General gene information

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Markers

Rrm1 (e-PCR), detects polymorphism
- UniSTS:507201

K02927 (e-PCR)
- UniSTS:159672

px-59h6 (e-PCR)
- UniSTS:257996

Homology

Homologs of the Rrm1 gene: The Rrm1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
Map Viewer (Human)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
catalytic activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
purine nucleotide binding	IDA Inferred from Direct Assay more info	PubMed
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IDA Inferred from Direct Assay more info	PubMed
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
DNA replication	IEA Inferred from Electronic Annotation more info
deoxyribonucleotide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
metabolic process	IEA Inferred from Electronic Annotation more info
oxidation-reduction process	IEA Inferred from Electronic Annotation more info
protein heterotetramerization	IPI Inferred from Physical Interaction more info	PubMed
protein oligomerization	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
ribonucleoside-diphosphate reductase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribonucleoside-diphosphate reductase large subunit

Names: ribonucleoside-diphosphate reductase large subunit; ribonucleotide reductase large subunit; ribonucleoside-diphosphate reductase subunit M1

NP_033129.2

EC 1.17.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009103.3 → NP_033129.2 ribonucleoside-diphosphate reductase large subunit

Status: VALIDATED

Source sequence(s)

AC132096, AK168586

Consensus CDS

CCDS40049.1

UniProtKB/Swiss-Prot

P07742

Related

ENSMUSP00000033283, ENSMUST00000033283

Conserved Domains (3) summary

cd01679
Location:167 – 741
Blast Score: 1972

RNR_I; Class I ribonucleotide reductase

PLN02437
Location:1 – 792
Blast Score: 3826

PLN02437; ribonucleoside--diphosphate reductase large subunit

pfam03477
Location:1 – 89
Blast Score: 161

ATP-cone; ATP cone domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000073.6 Reference GRCm38.p1 C57BL/6J

Range

102441695..102469771

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000029.1 Alternate Mm_Celera

Range

102809638..102837567

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01064953.1 (15271..43200)	None
genomic	AC132096.4 (63445..91521)	None
genomic	CH466531.1	EDL16601.1	mixed
		EDL16602.1	mixed
genomic	X72306.1	None	BALB/c
mRNA	AK049601.1	None	C57BL/6J
mRNA	AK082135.1	None	C57BL/6J
mRNA	AK088043.1	BAC40112.1	NOD
mRNA	AK137075.1	BAE23230.1	C57BL/6J
mRNA	AK168586.1	BAE40455.1	C57BL/6J
mRNA	AK184394.1	None
mRNA	AK186518.1	None
mRNA	AK190098.1	None
mRNA	AK192878.1	None
mRNA	AK199985.1	None
mRNA	AK200772.1	None
mRNA	AK203165.1	None
mRNA	AK207585.1	None
mRNA	AK209545.1	None
mRNA	AK209968.1	None
mRNA	AK210911.1	None
mRNA	AK211012.1	None
mRNA	AK211974.1	None
mRNA	AK213192.1	None
mRNA	AK213243.1	None
mRNA	AK215962.1	None
mRNA	AK215988.1	None
mRNA	AK218206.1	None
mRNA	AK218683.1	None
mRNA	AK219452.1	None
mRNA	AK220063.1	None
mRNA	BC003299.1	AAH03299.1	FVB/N
mRNA	BC016450.1	AAH16450.1	FVB/N
mRNA	BC066217.1	AAH66217.1	C3H/He
mRNA	K02927.1	AAA40061.1
mRNA	M14224.1	None