Format

Send to:

Choose Destination

RDM1 RAD52 motif containing 1 [ Homo sapiens (human) ]

Gene ID: 201299, updated on 8-May-2016
Official Symbol
RDM1provided by HGNC
Official Full Name
RAD52 motif containing 1provided by HGNC
Primary source
HGNC:HGNC:19950
See related
Ensembl:ENSG00000278023 HPRD:15205; MIM:612896; Vega:OTTHUMG00000188399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAD52B
Summary
This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (35918080..35930811, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34245084..34257780, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat containing 37 member A9, pseudogene Neighboring gene leucine rich repeat containing 37, member A3 pseudogene Neighboring gene lysozyme like 6 Neighboring gene C-C motif chemokine ligand 16

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC33977

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Cajal body IEA
Inferred from Electronic Annotation
more info
 
PML body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
RAD52 motif-containing protein 1
Names
RAD52 homolog B
RAD52 motif 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034836.1NP_001030008.1  RAD52 motif-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001030008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant(2) differs in the 3' coding region and UTR, compared to variant 1. This results in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC004675, BM559857
    Consensus CDS
    CCDS42299.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000482288, OTTHUMP00000276514, ENST00000613308, OTTHUMT00000477108
    Conserved Domains (2) summary
    smart00360
    Location:3593
    RRM; RNA recognition motif
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  2. NM_001163120.1NP_001156592.1  RAD52 motif-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001156592.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (3, also known as zeta) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BU599050, BX376188, EF488478
    Consensus CDS
    CCDS54110.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000483387, OTTHUMP00000276509, ENST00000612980, OTTHUMT00000477103
    Conserved Domains (2) summary
    smart00360
    Location:3593
    RRM; RNA recognition motif
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  3. NM_001163121.1NP_001156593.1  RAD52 motif-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001156593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4, also known as gamma) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BU599050, BX376188, EF488475
    Consensus CDS
    CCDS54111.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000478915, OTTHUMP00000276502, ENST00000616596, OTTHUMT00000477095
    Conserved Domains (2) summary
    smart00360
    Location:3593
    RRM; RNA recognition motif
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  4. NM_001163122.1NP_001156594.1  RAD52 motif-containing protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001156594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5, also known as DeltaN-gamma) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AW138754, BX376188, EF488481
    Consensus CDS
    CCDS59281.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000483933, OTTHUMP00000276507, ENST00000619828, OTTHUMT00000477101
    Conserved Domains (2) summary
    smart00360
    Location:1270
    RRM; RNA recognition motif
    cd12364
    Location:1072
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  5. NM_001163124.1NP_001156596.1  RAD52 motif-containing protein 1 isoform 6

    See identical proteins and their annotated locations for NP_001156596.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (6, also known as DeltaN-zeta) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AW138754, BX376188, EF488473
    Consensus CDS
    CCDS59280.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000479622, OTTHUMP00000276505, ENST00000617591, OTTHUMT00000477099
    Conserved Domains (3) summary
    smart00360
    Location:1270
    RRM; RNA recognition motif
    cd12364
    Location:1072
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
    cl01936
    Location:52113
    Rad52_Rad22; Rad52/22 family double-strand break repair protein
  6. NM_001163125.1NP_001156597.1  RAD52 motif-containing protein 1 isoform 7

    See identical proteins and their annotated locations for NP_001156597.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' and 3' UTRs and coding sequence and lacks an alternate internal coding exon compared to variant 1. The resulting isoform (7) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AA761980, AC244100, AW138754
    Consensus CDS
    CCDS54108.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000480131, OTTHUMP00000276515, ENST00000615378, OTTHUMT00000477109
    Conserved Domains (2) summary
    smart00360
    Location:1270
    RRM; RNA recognition motif
    cd12364
    Location:1072
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  7. NM_001163130.1NP_001156602.1  RAD52 motif-containing protein 1 isoform 8

    See identical proteins and their annotated locations for NP_001156602.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (8, also known as DeltaN-alpha) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AW138754, BX376188, EF488479
    Consensus CDS
    CCDS54109.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000479310, OTTHUMP00000276504, ENST00000619262, OTTHUMT00000477097
    Conserved Domains (2) summary
    smart00360
    Location:1270
    RRM; RNA recognition motif
    cd12364
    Location:1072
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  8. NM_145654.3NP_663629.1  RAD52 motif-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_663629.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1, also known as isoform alpha).
    Source sequence(s)
    AB080728, BU599050, BX376188
    Consensus CDS
    CCDS11301.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000483549, OTTHUMP00000276503, ENST00000620284, OTTHUMT00000477096
    Conserved Domains (2) summary
    smart00360
    Location:3593
    RRM; RNA recognition motif
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins

RNA

  1. NR_027996.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as delta) lacks two alternate coding exons compared to variant 1. The lack of one of the exons causes a frameshift and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
    Source sequence(s)
    BU599050, BX376188, EF488476
  2. NR_027997.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10, also known as beta) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
    Source sequence(s)
    BU599050, BX376188, EF488474
  3. NR_027998.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11, also known as epsilon) lacks two alternate coding exons compared to variant 1. The lack of one of the exons causes a frameshift and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
    Source sequence(s)
    BU599050, BX376188, EF488477
  4. NR_027999.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12, also known as DeltaN-epsilon) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1. The lack of one of the exons causes a frameshift and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
    Source sequence(s)
    AW138754, BX376188, EF488482
  5. NR_028000.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13, also known as DeltaN-beta) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
    Source sequence(s)
    AW138754, BX376188, EF488480

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    35918080..35930811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524509.1XP_011522811.1  

    See identical proteins and their annotated locations for XP_011522811.1

    Conserved Domains (2) summary
    smart00360
    Location:3593
    RRM; RNA recognition motif
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  2. XM_011524510.1XP_011522812.1  

    See identical proteins and their annotated locations for XP_011522812.1

    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000482981, OTTHUMP00000276512, ENST00000619193, OTTHUMT00000477106
    Conserved Domains (2) summary
    smart00360
    Location:3593
    RRM; RNA recognition motif
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    152612..165343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011546795.1XP_011545097.1  

    See identical proteins and their annotated locations for XP_011545097.1

    Conserved Domains (2) summary
    smart00360
    Location:3593
    RRM; RNA recognition motif
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  2. XM_011546796.1XP_011545098.1  

    See identical proteins and their annotated locations for XP_011545098.1

    UniProtKB/Swiss-Prot
    Q8NG50
    Conserved Domains (2) summary
    smart00360
    Location:3593
    RRM; RNA recognition motif
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    34309651..34322347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)