These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_029771.1 RefSeqGene
- Range
- 5001..77093
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001039469.2 → NP_001034558.2 serine/threonine-protein kinase MARK2 isoform d
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
- Source sequence(s)
-
AB188493, AK225766, AP003780, BC008771, BM719402
- Consensus CDS
-
CCDS53649.1
- UniProtKB/Swiss-Prot
-
Q7KZI7
- Related
- ENSP00000385751, ENST00000402010
- Conserved Domains (4) summary
-
- cd00194
Location:325 – 362
Blast Score: 98
- UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
- cd05123
Location:59 – 304
Blast Score: 675
- STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
- pfam02149
Location:746 – 788
Blast Score: 181
- KA1; Kinase associated domain 1
- smart00220
Location:53 – 304
Blast Score: 880
- S_TKc; Serine/Threonine protein kinases, catalytic domain
-
NM_001163296.1 → NP_001156768.1 serine/threonine-protein kinase MARK2 isoform e
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 3' coding region, compared to variant 4. The resulting isoform (e) lacks two internal segments, compared to isoform d.
- Source sequence(s)
-
AB188493, AK225766, AP003780, BM719402
- Consensus CDS
-
CCDS53650.1
- UniProtKB/Swiss-Prot
-
Q7KZI7
- Related
- ENSP00000355091, OTTHUMP00000236749, ENST00000361128, OTTHUMT00000396087
- Conserved Domains (4) summary
-
- cd05123
Location:59 – 304
Blast Score: 673
- STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
- pfam02149
Location:677 – 719
Blast Score: 180
- KA1; Kinase associated domain 1
- smart00220
Location:53 – 304
Blast Score: 878
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cl00153
Location:325 – 361
Blast Score: 112
- UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
-
NM_001163297.1 → NP_001156769.1 serine/threonine-protein kinase MARK2 isoform f
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) lacks three alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (f) lacks two internal segments and 1 internal residue, compared to isoform d.
- Source sequence(s)
-
AB188493, AK225766, AP003780, BM719402
- Consensus CDS
-
CCDS53651.1
- UniProtKB/Swiss-Prot
-
Q7KZI7
- Related
- ENSP00000294247, OTTHUMP00000236750, ENST00000350490, OTTHUMT00000396088
- Conserved Domains (4) summary
-
- cd00194
Location:325 – 362
Blast Score: 98
- UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
- cd05123
Location:59 – 304
Blast Score: 673
- STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
- pfam02149
Location:667 – 709
Blast Score: 180
- KA1; Kinase associated domain 1
- smart00220
Location:53 – 304
Blast Score: 877
- S_TKc; Serine/Threonine protein kinases, catalytic domain
-
NM_004954.4 → NP_004945.4 serine/threonine-protein kinase MARK2 isoform c
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (c) lacks two internal segments and 1 internal residue, compared to isoform d.
- Source sequence(s)
-
AB188493, AK225766, AP003780, BC084540, BM719402
- Consensus CDS
-
CCDS8051.2
- UniProtKB/Swiss-Prot
-
Q7KZI7
- Related
- ENSP00000425765, OTTHUMP00000218338, ENST00000508192, OTTHUMT00000360860
- Conserved Domains (4) summary
-
- cd05123
Location:59 – 304
Blast Score: 673
- STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
- pfam02149
Location:682 – 724
Blast Score: 180
- KA1; Kinase associated domain 1
- smart00220
Location:53 – 304
Blast Score: 877
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cl00153
Location:325 – 361
Blast Score: 112
- UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
-
NM_017490.3 → NP_059672.2 serine/threonine-protein kinase MARK2 isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, lacks an in-frame exon, and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (a) has a shorter N-terminus and lacks an internal segment and 1 internal residue, compared to isoform d.
- Source sequence(s)
-
AK290339, AP003780, BM719402, BT007342, DA855402
- Consensus CDS
-
CCDS41665.1
- UniProtKB/TrEMBL
-
A8K2S4
- UniProtKB/Swiss-Prot
-
Q7KZI7
- Related
- ENSP00000423974, OTTHUMP00000218340, ENST00000509502, OTTHUMT00000360862
- Conserved Domains (4) summary
-
- cd00194
Location:292 – 329
Blast Score: 98
- UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
- cd05123
Location:26 – 271
Blast Score: 674
- STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
- pfam02149
Location:703 – 745
Blast Score: 180
- KA1; Kinase associated domain 1
- smart00220
Location:20 – 271
Blast Score: 878
- S_TKc; Serine/Threonine protein kinases, catalytic domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000011.9 Reference GRCh37.p5 Primary Assembly
- Range
- 63606400..63678492
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000143.1 Alternate HuRef
- Range
- 59934874..60007522
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)