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MARK2 microtubule affinity regulating kinase 2 [ Homo sapiens (human) ]

Gene ID: 2011, updated on 8-May-2016
Official Symbol
MARK2provided by HGNC
Official Full Name
microtubule affinity regulating kinase 2provided by HGNC
Primary source
HGNC:HGNC:3332
See related
Ensembl:ENSG00000072518 HPRD:02753; MIM:600526
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMK1; EMK-1; PAR-1; Par1b; Par-1b
Summary
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Orthologs
Location:
11q13.1
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (63838928..63911020)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63606400..63678492)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 84 Neighboring gene atherin-like Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex subunit G pseudogene 1 Neighboring gene uncharacterized LOC105369336 Neighboring gene transfer RNA-Arg (CCT) 9-1 Neighboring gene REST corepressor 2 Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC99619

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
establishment of cell polarity IDA
Inferred from Direct Assay
more info
PubMed 
establishment of cell polarity TAS
Traceable Author Statement
more info
PubMed 
establishment or maintenance of epithelial cell apical/basal polarity IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion localization NAS
Non-traceable Author Statement
more info
PubMed 
mitophagy NAS
Non-traceable Author Statement
more info
PubMed 
neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-threonine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule bundle IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase MARK2
Names
ELKL motif kinase 1
MAP/microtubule affinity-regulating kinase 2
MARK2
PAR1 homolog b
Ser/Thr protein kinase PAR-1B
serine/threonine protein kinase EMK
testicular tissue protein Li 117
NP_001034558.2
NP_001156768.1
NP_001156769.1
NP_004945.4
NP_059672.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029771.1 RefSeqGene

    Range
    5001..77093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039469.2NP_001034558.2  serine/threonine-protein kinase MARK2 isoform d

    See identical proteins and their annotated locations for NP_001034558.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AB188493, AK225766, AP003780, BC008771, BM719402
    Consensus CDS
    CCDS53649.1
    UniProtKB/Swiss-Prot
    Q7KZI7
    Related
    ENSP00000385751, ENST00000402010
    Conserved Domains (4) summary
    cd12201
    Location:689787
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:53304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:322363
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:52304
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  2. NM_001163296.1NP_001156768.1  serine/threonine-protein kinase MARK2 isoform e

    See identical proteins and their annotated locations for NP_001156768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 3' coding region, compared to variant 4. The resulting isoform (e) lacks two internal segments, compared to isoform d.
    Source sequence(s)
    AB188493, AK225766, AP003780, BM719402
    Consensus CDS
    CCDS53650.1
    UniProtKB/Swiss-Prot
    Q7KZI7
    Related
    ENSP00000355091, OTTHUMP00000236749, ENST00000361128, OTTHUMT00000396087
    Conserved Domains (4) summary
    cd12201
    Location:620718
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:53304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:322363
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:52304
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  3. NM_001163297.1NP_001156769.1  serine/threonine-protein kinase MARK2 isoform f

    See identical proteins and their annotated locations for NP_001156769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks three alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (f) lacks two internal segments and 1 internal residue, compared to isoform d.
    Source sequence(s)
    AB188493, AK225766, AP003780, BM719402
    Consensus CDS
    CCDS53651.1
    UniProtKB/Swiss-Prot
    Q7KZI7
    Related
    ENSP00000294247, OTTHUMP00000236750, ENST00000350490, OTTHUMT00000396088
    Conserved Domains (4) summary
    cd12201
    Location:610708
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:53304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:322363
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:52304
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  4. NM_004954.4NP_004945.4  serine/threonine-protein kinase MARK2 isoform c

    See identical proteins and their annotated locations for NP_004945.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (c) lacks two internal segments and 1 internal residue, compared to isoform d.
    Source sequence(s)
    AB188493, AK225766, AP003780, BC084540, BM719402
    Consensus CDS
    CCDS8051.2
    UniProtKB/Swiss-Prot
    Q7KZI7
    Related
    ENSP00000425765, OTTHUMP00000218338, ENST00000508192, OTTHUMT00000360860
    Conserved Domains (4) summary
    cd12201
    Location:625723
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:53304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:322363
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:52304
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  5. NM_017490.3NP_059672.2  serine/threonine-protein kinase MARK2 isoform a

    See identical proteins and their annotated locations for NP_059672.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, lacks an in-frame exon, and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (a) has a shorter N-terminus and lacks an internal segment and 1 internal residue, compared to isoform d.
    Source sequence(s)
    AK290339, AP003780, BM719402, BT007342, DA855402
    Consensus CDS
    CCDS41665.1
    UniProtKB/Swiss-Prot
    Q7KZI7
    UniProtKB/TrEMBL
    A8K2S4
    Related
    ENSP00000423974, OTTHUMP00000218340, ENST00000509502, OTTHUMT00000360862
    Conserved Domains (4) summary
    cd12201
    Location:646744
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:20271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:289330
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:19271
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    63838928..63911020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544789.1XP_011543091.1  

    Conserved Domains (4) summary
    cd12201
    Location:709807
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  2. XM_011544792.1XP_011543094.1  

    Conserved Domains (4) summary
    cd12201
    Location:694792
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  3. XM_011544790.1XP_011543092.1  

    Conserved Domains (4) summary
    cd12201
    Location:700798
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  4. XM_011544793.1XP_011543095.1  

    Conserved Domains (4) summary
    cd12201
    Location:685783
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  5. XM_011544797.1XP_011543099.1  

    Conserved Domains (4) summary
    cd12201
    Location:640738
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  6. XM_011544795.1XP_011543097.1  

    Conserved Domains (4) summary
    cd12201
    Location:646744
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  7. XM_011544791.1XP_011543093.1  

    Conserved Domains (4) summary
    cd12201
    Location:699797
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  8. XM_011544794.1XP_011543096.1  

    Conserved Domains (4) summary
    cd12201
    Location:654752
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  9. XM_011544796.1XP_011543098.1  

    Conserved Domains (4) summary
    cd12201
    Location:645743
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  10. XM_011544798.1XP_011543100.1  

    Conserved Domains (4) summary
    cd12201
    Location:630728
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RNA

  1. XR_949802.1 RNA Sequence

  2. XR_949801.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    63489428..63561505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)