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LIPH lipase, member H [ Homo sapiens (human) ]

Gene ID: 200879, updated on 30-Oct-2014
Official Symbol
LIPHprovided by HGNC
Official Full Name
lipase, member Hprovided by HGNC
Primary source
HGNC:HGNC:18483
See related
Ensembl:ENSG00000163898; HPRD:07392; MIM:607365; Vega:OTTHUMG00000156657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AH; LAH2; ARWH2; HYPT7; LPDLR; PLA1B; mPA-PLA1
Summary
This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]
See LIPH in Epigenomics, MapViewer
Location:
3q27
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (185507782..185552588, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185225570..185270369, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 13 Neighboring gene uncharacterized LOC101929018 Neighboring gene transmembrane protein 41A Neighboring gene ribosomal protein L34 pseudogene 10 Neighboring gene SUMO1/sentrin/SMT3 specific peptidase 2 Neighboring gene insulin-like growth factor 2 mRNA binding protein 2 Neighboring gene IGF2BP2 antisense RNA 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
lipase member H
Names
lipase member H
lipase H
mPA-PLA1 alpha
phospholipase A1 member B
LPD lipase-related protein
membrane-bound phosphatidic acid-selective phospholipase A1
membrane-associated phosphatidic acid-selective phospholipase A1-alpha
NP_640341.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012183.1 

    Range
    5001..49800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139248.2NP_640341.1  lipase member H precursor

    See proteins identical to NP_640341.1

    Status: REVIEWED

    Source sequence(s)
    AK122651, BC064941, BI965988
    Consensus CDS
    CCDS3272.1
    UniProtKB/Swiss-Prot
    Q8WWY8
    Conserved Domains (1) summary
    cd00707
    Location:39303
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    185507782..185552588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713530.1XP_006713593.1  

    See proteins identical to XP_006713593.1

    UniProtKB/TrEMBL
    A2IBA6
    Related
    ENSP00000396384, OTTHUMP00000210344, ENST00000424591, OTTHUMT00000345154
    Conserved Domains (1) summary
    cd00707
    Location:39269
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation, ...
  2. XM_006713529.1XP_006713592.1  

    Conserved Domains (1) summary
    cd00707
    Location:39273
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation, ...

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    182635165..182680037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    185188581..185233458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)