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LIPH lipase, member H [ Homo sapiens (human) ]

Gene ID: 200879, updated on 19-Apr-2015
Official Symbol
LIPHprovided by HGNC
Official Full Name
lipase, member Hprovided by HGNC
Primary source
HGNC:HGNC:18483
See related
Ensembl:ENSG00000163898; HPRD:07392; MIM:607365; Vega:OTTHUMG00000156657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AH; LAH2; ARWH2; HYPT7; LPDLR; PLA1B; mPA-PLA1
Summary
This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]
Orthologs
See LIPH in MapViewer
Location:
3q27
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (185506866..185552655, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185225570..185270369, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 13 Neighboring gene uncharacterized LOC105374254 Neighboring gene transmembrane protein 41A Neighboring gene ribosomal protein L34 pseudogene 10 Neighboring gene SUMO1/sentrin/SMT3 specific peptidase 2 Neighboring gene insulin-like growth factor 2 mRNA binding protein 2 Neighboring gene IGF2BP2 antisense RNA 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
lipase member H
Names
lipase member H
LPD lipase-related protein
lipase H
mPA-PLA1 alpha
membrane-associated phosphatidic acid-selective phospholipase A1-alpha
membrane-bound phosphatidic acid-selective phospholipase A1
phospholipase A1 member B
NP_640341.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012183.1 RefSeqGene

    Range
    5001..49800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139248.2NP_640341.1  lipase member H precursor

    See identical proteins and their annotated locations for NP_640341.1

    Status: REVIEWED

    Source sequence(s)
    AK122651, BC064941, BI965988
    Consensus CDS
    CCDS3272.1
    UniProtKB/Swiss-Prot
    Q8WWY8
    Related
    ENSP00000396384, OTTHUMP00000210344, ENST00000424591, OTTHUMT00000345154
    Conserved Domains (1) summary
    cd00707
    Location:39303
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    185506866..185552655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512530.1XP_011510832.1  

    See identical proteins and their annotated locations for XP_011510832.1

    Conserved Domains (1) summary
    cd00707
    Location:1260
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation, ...
  2. XM_006713529.2XP_006713592.1  

    Related
    ENSP00000296252, OTTHUMP00000210343, ENST00000296252, OTTHUMT00000345153
    Conserved Domains (1) summary
    cd00707
    Location:39273
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation, ...
  3. XM_011512531.1XP_011510833.1  

    See identical proteins and their annotated locations for XP_011510833.1

    Conserved Domains (1) summary
    cd00707
    Location:1260
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation, ...

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    185188581..185233458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)