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LIPH lipase H [ Homo sapiens (human) ]

Gene ID: 200879, updated on 3-Jul-2016
Official Symbol
LIPHprovided by HGNC
Official Full Name
lipase Hprovided by HGNC
Primary source
HGNC:HGNC:18483
See related
Ensembl:ENSG00000163898 HPRD:07392; MIM:607365; Vega:OTTHUMG00000156657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AH; LAH2; ARWH2; HYPT7; LPDLR; PLA1B; mPA-PLA1
Summary
This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3q27
Exon count:
12
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (185506262..185552661, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185225570..185270369, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 13 Neighboring gene uncharacterized LOC105374254 Neighboring gene transmembrane protein 41A Neighboring gene uncharacterized LOC107986055 Neighboring gene SUMO1/sentrin/SMT3 specific peptidase 2 Neighboring gene ribosomal protein L34 pseudogene 10

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Digestion of dietary lipid, organism-specific biosystem (from REACTOME)
    Digestion of dietary lipid, organism-specific biosystemDietary lipids such as long-chain triacylglycerols and cholesterol esters are digested in the stomach and small intestine to yield long-chain fatty acids, monoacylglycerols, glycerol and cholesterol ...
  • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
    Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid digestion TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
lipase member H
Names
LPD lipase-related protein
lipase, member H
mPA-PLA1 alpha
membrane-associated phosphatidic acid-selective phospholipase A1-alpha
membrane-bound phosphatidic acid-selective phospholipase A1
phospholipase A(1)
phospholipase A1 member B
NP_640341.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012183.1 RefSeqGene

    Range
    5001..49800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139248.2NP_640341.1  lipase member H precursor

    See identical proteins and their annotated locations for NP_640341.1

    Status: REVIEWED

    Source sequence(s)
    AK122651, BC064941, BI965988
    Consensus CDS
    CCDS3272.1
    UniProtKB/Swiss-Prot
    Q8WWY8
    Related
    ENSP00000296252, OTTHUMP00000210343, ENST00000296252, OTTHUMT00000345153
    Conserved Domains (1) summary
    cd00707
    Location:39303
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

    Range
    185506262..185552661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512530.2XP_011510832.1  

    See identical proteins and their annotated locations for XP_011510832.1

    Conserved Domains (1) summary
    cd00707
    Location:1260
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
  2. XM_017005852.1XP_016861341.1  

    Related
    ENSP00000396384, OTTHUMP00000210344, ENST00000424591, OTTHUMT00000345154
  3. XM_006713529.3XP_006713592.1  

    Conserved Domains (1) summary
    cd00707
    Location:39273
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
  4. XM_011512531.2XP_011510833.1  

    See identical proteins and their annotated locations for XP_011510833.1

    Conserved Domains (1) summary
    cd00707
    Location:1260
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    185188581..185233458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)