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SPRED2 sprouty related EVH1 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 200734, updated on 26-May-2016
Official Symbol
SPRED2provided by HGNC
Official Full Name
sprouty related EVH1 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:17722
See related
Ensembl:ENSG00000198369 HPRD:18100; MIM:609292; Vega:OTTHUMG00000152737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Spred-2
Summary
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
2p14
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (65307435..65432637, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (65534580..65659733, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 2 pseudogene Neighboring gene ARP2 actin-related protein 2 homolog (yeast) Neighboring gene WAS/WASL-interacting protein family member 1-like Neighboring gene uncharacterized LOC105374780 Neighboring gene uncharacterized LOC440867 Neighboring gene uncharacterized LOC105369166 Neighboring gene uncharacterized LOC105374781 Neighboring gene DnaJ heat shock protein family (Hsp40) member B12 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
NHGRI GWA Catalog
Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.
NHGRI GWA Catalog
  • ARMS-mediated activation, organism-specific biosystem (from REACTOME)
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  • FRS-mediated FGFR3 signaling, organism-specific biosystem (from REACTOME)
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    Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
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    Frs2-mediated activation, organism-specific biosystemThe adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.
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    GRB2 events in EGFR signaling, organism-specific biosystemAutophosphorylated EGFR tyrosine residues are docking sites for many downstream effectors in EGFR signaling. The adaptor protein GRB2 binds to phosphotyrosine residues in the C-tail of EGFR through i...
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    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
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    IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
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    IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
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    Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
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    Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
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    Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
  • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
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    MAPK1/MAPK3 signaling, organism-specific biosystemThe extracellular signal regulated kinases (ERKs) 1 and 2, also known as MAPK3 and MAPK1, are phosphorylated by the MAP2Ks 1 and 2 in response to a wide range of extracellular stimuli to promote diff...
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    NCAM signaling for neurite out-growth, organism-specific biosystemThe neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the n...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, organism-specific biosystem (from REACTOME)
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  • Prolonged ERK activation events, organism-specific biosystem (from REACTOME)
    Prolonged ERK activation events, organism-specific biosystemAfter NGF binding, activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich Membrane Spanning protein (ARMS/Kidins220) and Fibro...
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    Regulation of RAS by GAPs, organism-specific biosystemThe intrinsic GTPase activity of RAS proteins is stimulated by the GAP proteins, of which there are at least 10 in the human genome (reviewed in King et al, 2013).
  • SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
    SHC1 events in EGFR signaling, organism-specific biosystemGRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.
  • SHC1 events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
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  • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
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  • Signal Transduction, organism-specific biosystem (from REACTOME)
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  • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
    Signaling events mediated by Stem cell factor receptor (c-Kit)
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
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  • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ21897, FLJ31917, MGC163164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
stem cell factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
inactivation of MAPK activity ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA damage response, signal transduction by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of protein deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
sprouty-related, EVH1 domain-containing protein 2
Names
sprouty protein with EVH-1 domain 2, related sequence
sprouty related, EVH1 domain containing 2
sprouty-related, EVH1 domain containing 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128210.1NP_001121682.1  sprouty-related, EVH1 domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_001121682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK056479, AY299090, BC130292, DC335282
    Consensus CDS
    CCDS46308.1
    UniProtKB/Swiss-Prot
    Q7Z698
    UniProtKB/TrEMBL
    B3KPL5
    Related
    ENSP00000393697, OTTHUMP00000225519, ENST00000443619, OTTHUMT00000376661
    Conserved Domains (2) summary
    pfam05210
    Location:303408
    Sprouty; Sprouty protein (Spry)
    cd10574
    Location:9121
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
  2. NM_181784.2NP_861449.2  sprouty-related, EVH1 domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_861449.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK056479, AY299090, BC130292, DA102390
    Consensus CDS
    CCDS33211.1
    UniProtKB/Swiss-Prot
    Q7Z698
    UniProtKB/TrEMBL
    B3KPL5
    Related
    ENSP00000348753, OTTHUMP00000202294, ENST00000356388, OTTHUMT00000327632
    Conserved Domains (2) summary
    pfam05210
    Location:306411
    Sprouty; Sprouty protein (Spry)
    cd10574
    Location:12124
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    65307435..65432637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264200.3XP_005264257.2  

    Conserved Domains (1) summary
    cd10574
    Location:12124
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
  2. XM_005264202.3XP_005264259.1  

    Conserved Domains (1) summary
    cd10574
    Location:12124
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
  3. XM_006711966.1XP_006712029.1  

    See identical proteins and their annotated locations for XP_006712029.1

    UniProtKB/Swiss-Prot
    Q7Z698
    Conserved Domains (2) summary
    pfam05210
    Location:306411
    Sprouty; Sprouty protein (Spry)
    cd10574
    Location:12124
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
  4. XM_005264201.1XP_005264258.1  

    Conserved Domains (1) summary
    pfam05210
    Location:109212
    Sprouty; Sprouty protein (Spry)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    65469340..65590964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)