These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_021188.1 RefSeqGene
- Range
- 5001..97485
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001178000.1 → NP_001171471.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform 4
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) lacks all of the 3' coding region and UTR, compared to variant 2. The encoded protein (isoform 4) has an identical N-terminus but a short novel C-terminus, compared to isoform 2.
- Source sequence(s)
-
BC032389, BC125053
- Consensus CDS
-
CCDS54431.1
- UniProtKB/Swiss-Prot
-
Q9Y2I7
- Related
- ENSP00000384356, OTTHUMP00000198101, ENST00000407449, OTTHUMT00000319312
- Conserved Domains (3) summary
-
- cd00065
Location:161 – 213
Blast Score: 192
- FYVE; FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1;
- cd04448
Location:357 – 438
Blast Score: 401
- DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
- pfam01363
Location:154 – 219
Blast Score: 223
- FYVE; FYVE zinc finger
-
NM_015040.3 → NP_055855.2 1-phosphatidylinositol 3-phosphate 5-kinase isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
- Source sequence(s)
-
AB023198, AC012362, AY457063
- Consensus CDS
-
CCDS2382.1
- UniProtKB/Swiss-Prot
-
Q9Y2I7
- Related
- ENSP00000264380, OTTHUMP00000163872, ENST00000264380, OTTHUMT00000256477
- Conserved Domains (5) summary
-
- cd00065
Location:161 – 213
Blast Score: 202
- FYVE; FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1;
- cd03334
Location:633 – 877
Blast Score: 970
- Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
- cd00139
Location:1772 – 2085
Blast Score: 914
- PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
- cd04448
Location:357 – 438
Blast Score: 403
- DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
- pfam01363
Location:154 – 219
Blast Score: 233
- FYVE; FYVE zinc finger
-
NM_152671.3 → NP_689884.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks two in-frame exons in the 5' coding region and all of the 3' coding region and UTR, compared to variant 2. The encoded protein (isoform 3) has a shorter N-terminus and a short novel C-terminus, compared to isoform 2.
- Source sequence(s)
-
BC032389
- Consensus CDS
-
CCDS33368.1
- UniProtKB/Swiss-Prot
-
Q9Y2I7
- Related
- ENSP00000376038, OTTHUMP00000198099, ENST00000392202, OTTHUMT00000319310
- Conserved Domains (1) summary
-
- cd04448
Location:260 – 341
Blast Score: 405
- DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000002.11 Reference GRCh37.p5 Primary Assembly
- Range
- 209130991..209223475
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000134.1 Alternate HuRef
- Range
- 200978970..201070591
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the cited
reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links,
or BLAST links (BLink), but may still be retrieved by clicking on their
accession.version below.
-
NM_001002881.1: Suppressed sequence
- Description
- NM_001002881.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.