CRTC2 CREB regulated transcription coactivator 2 [Homo sapiens] - Gene

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Summary

Official Symbol: CRTC2provided by HGNC
Official Full Name: CREB regulated transcription coactivator 2provided by HGNC
Primary source: HGNC:27301
Locus tag: RP11-422P24.6
See related: Ensembl:ENSG00000160741; HPRD:12347; MIM:608972; Vega:OTTHUMG00000037156
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TORC2; TORC-2
Summary: This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]

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Genomic context

Location :: 1q21.3

Sequence :: Chromosome: 1; NC_000001.10 (153920148..153931132, complement)

See CRTC2 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our findings provide new mechanistic insights into the role of mTORC2 in BCR-ABL(+) cells and indicate that regulation by GILZ may influence TKI sensitivity.
Title: GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells.
multiple-site acetylation of Rictor signals for increased activation of mTORC2, providing a critical link between nutrient-sensitive deacetylases and mTORC2 signaling to Akt
Title: Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein.
Data show that mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) are up-regulated in neoplastic and developing immature mast cells compared with their terminally differentiated counterparts.
Title: mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells.
Studies form the basis for further clinical testing of mammalian target of rapamycin (mTOR) complexes TORC1/2 inhibitors in multiple myeloma.
Title: Defining the role of TORC1/2 in multiple myeloma.
mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel
Title: mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.
Selective activation of Akt1 through mTORC2 and P-Rex1 regulates cancer cell migration, invasion and metastasis.
Title: Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.
reconstituted high-density lipoprotein inhibits senescence onset in circulating angiogenic cells through mTOR complex 2 pathway activation
Title: mTOR complex 2 activation by reconstituted high-density lipoprotein prevents senescence in circulating angiogenic cells.
mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif
Title: mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif.
mTORC2-addicted cells require mitochondrial functions that may be novel drug targets in human cancer.
Title: Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction.
The activation with overexpression of components of the mTORC2-PLD1 pathway in ULMS and to a lesser degree in STUMP provides insight into their tumorigenic mechanisms.
Title: Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications.

Submit: New GeneRIF Correction See all (24)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_859066.1	NP_000935.1	PPP3CA	BIND	PubMed	TORC2 interacts with CnA.
NP_859066.1	NP_056006.1	SIK2	BIND	PubMed	TORC2 interacts with SIK2.
NP_859066.1	NP_003395.1	YWHAB	BIND	PubMed	TORC2 interacts with 14-3-3-beta.
Transducer of regulated cAMP response element binding protein 2	Q08209	PPP3CA	HPRD	PubMed
Transducer of regulated cAMP response element binding protein 2	P57059	SIK1	HPRD	PubMed
Transducer of regulated cAMP response element binding protein 2	Q9H0K1	SIK2	HPRD	PubMed
Transducer of regulated cAMP response element binding protein 2	KIAA0999 protein	SIK3	HPRD	PubMed
Transducer of regulated cAMP response element binding protein 2	P31946	YWHAB	HPRD	PubMed
Transducer of regulated cAMP response element binding protein 2	P61981	YWHAG	HPRD	PubMed
Transducer of regulated cAMP response element binding protein 2	P63104	YWHAZ	HPRD	PubMed
BioGRID:128308	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western
BioGRID:128308	BioGRID:113954	HIST1H3B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:128308	BioGRID:122136	RFWD2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:128308	BioGRID:116840	SIK2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:128308	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:128308	BioGRID:113361	YWHAB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:128308	BioGRID:113364	YWHAG	BioGRID	PubMed	Affinity Capture-MS
BioGRID:128308	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
cAMP response element binding protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
interspecies interaction between organisms	IEA Inferred from Electronic Annotation more info
positive regulation of CREB transcription factor activity	IEA Inferred from Electronic Annotation more info
positive regulation of CREB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
protein homotetramerization	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: CREB-regulated transcription coactivator 2

Names: CREB-regulated transcription coactivator 2; transducer of regulated cAMP response element-binding protein (CREB) 2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181715.2 → NP_859066.1 CREB-regulated transcription coactivator 2

Status: REVIEWED

Source sequence(s)

AY360172, AY726597, BC053562, BI550818, BM987537

Consensus CDS

CCDS30875.1

UniProtKB/Swiss-Prot

Q53ET0

Related

ENSP00000357622, OTTHUMP00000035255, ENST00000368633, OTTHUMT00000090272

Conserved Domains (3) summary

pfam12884
Location:18 – 72
Blast Score: 223

TORC_N; Transducer of regulated CREB activity, N terminus

pfam12885
Location:168 – 320
Blast Score: 367

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:615 – 692
Blast Score: 237

TORC_C; Transducer of regulated CREB activity, C terminus

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

153920148..153931132, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

125282734..125293718, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL358472.54	CAI14017.1
		CAI14018.1
mRNA	AF289574.1	AAL55758.1
mRNA	AK096382.1	BAG53277.1
mRNA	AK223559.1	BAD97279.1
mRNA	AY360172.1	AAQ98857.1
mRNA	AY726597.1	None
mRNA	BC028886.1	AAH28886.1
mRNA	BC033304.1	None
mRNA	BC053562.1	AAH53562.1
mRNA	BI550818.1	None
mRNA	BM987537.1	None

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q53ET0.2	GenPept	UniProtKB/Swiss-Prot:Q53ET0
Q5T4K5	GenPept	UniProtKB/TrEMBL:Q5T4K5
Q8N332	GenPept	UniProtKB/TrEMBL:Q8N332
Q8WZ18	GenPept	UniProtKB/TrEMBL:Q8WZ18