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    ELF4 E74-like factor 4 (ets domain transcription factor) [ Homo sapiens ]

    Gene ID: 2000, updated on 11-May-2012
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    Summary

    Official Symbol
    ELF4provided by HGNC
    Official Full Name
    E74-like factor 4 (ets domain transcription factor)provided by HGNC
    Primary source
    HGNC:3319
    Locus tag
    RP3-510O21.2
    See related
    Ensembl:ENSG00000102034; HPRD:06499; MIM:300775; Vega:OTTHUMG00000022390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEF; ELFR
    Summary
    The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
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    Genomic context

    Location :
    Xq26
    Sequence :
    Chromosome: X; NC_000023.10 (129198895..129244688, complement)
    See ELF4 in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) Neighboring gene BCL6 corepressor-like 1 Neighboring gene apoptosis-inducing factor, mitochondrion-associated, 1 Neighboring gene RAB33A, member RAS oncogene family

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. PTH regulates myleoid ELF-1-like factor (MEF)-induced MAB-21-like-1 (MAB21L1) expression through the JNK1 pathway. Kim BG, et al. J Cell Biochem, 2011 Aug. PMID 21465527.
    3. The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow. Sivina M, et al. Arterioscler Thromb Vasc Biol, 2011 May. PMID 21350194.
    4. Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2. Yamada T, et al. Nat Immunol, 2009 Jun. PMID 19412182.
    5. The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor. Zhou W, et al. BMB Rep, 2009 Mar 31. PMID 19336002.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. MEF is involved in PTH suppression of osteoblasts through activating the MKK4/JNK1 pathway and subsequently up-regulating Mab21l1 expression.
      Title: PTH regulates myleoid ELF-1-like factor (MEF)-induced MAB-21-like-1 (MAB21L1) expression through the JNK1 pathway.
    2. Loss of ELF4 leads to increased quiescence in bone marrow endothelial cells by the deregulation of cyclin-dependent kinase-4 expression and to enhanced regeneration of sinusoidal blood vessels.
      Title: The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow.
    3. regulation in epithelial cells by Sp1
      Title: Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells.
    4. RT-PCR analysis of RNA isolated from bone marrow samples from the patient demonstrates that the translocation occurs within intron 1 of ERG isoform 1 and intron 2 of ELF4 resulting in an in-frame fusion joining exon 2 from ELF4 with exon 2 of ERG.
      Title: ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22).
    5. MEF activated HBD2 promoter activity, and increased the endogenous HBD2 transcription level. The activated HBD2 promoter activity was attenuated by the antisense MEF RNA input and the loss of the ETS binding site in the HBD2 promoter
      Title: MEF up-regulates human beta-defensin 2 expression in epithelial cells.
    6. promyelocytic leukemia protein, but not Sp100, induced the accumulation of MEF in PML nuclear bodies and MEF and PML physically interacted, stimulating MEF transcriptional activity, resulting in the up-regulation of endogenous lysozyme expression.
      Title: Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein.
    7. MEF is an important regulator of IL-8 expression
      Title: Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells.
    8. Functional dissection of the transactivation mechanisms of the ETS transcription factor MEF
      Title: Functional dissection of the ETS transcription factor MEF.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q99607 Q9UKT5 FBXO4    HPRD  PubMed  
    Q99607 Q9Y3I1 FBXO7    HPRD  PubMed  
    Q99607 P29590 PML    HPRD  PubMed  
    Q99607 Q01196 RUNX1    HPRD  PubMed  
    Q99607 Q13309 SKP2    HPRD  PubMed  
    Q99607 Ubiquitin B UBB    HPRD  PubMed  
    BioGRID:108315 BioGRID:115984 KDM5B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108315 BioGRID:107309 RUNX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108315 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108315 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    NK T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    natural killer cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    ETS-related transcription factor Elf-4
    Names
    ETS-related transcription factor Elf-4
    myeloid Elf-1-like factor
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016388.1 RefSeqGene

      Range
      5001..50794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001127197.1 → NP_001120669.1  ETS-related transcription factor Elf-4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK314972, BC017194
      Consensus CDS
      CCDS14617.1
      UniProtKB/Swiss-Prot
      Q99607
      Related
      ENSP00000338608, OTTHUMP00000024004, ENST00000335997, OTTHUMT00000058244
      Conserved Domains (2) summary
      pfam12310
      Location:1 – 104
      Blast Score: 373
      Elf-1_N; Transcription factor protein N terminal
      cl02599
      Location:208 – 290
      Blast Score: 400
      Ets; Ets-domain

    2. NM_001421.3 → NP_001412.1  ETS-related transcription factor Elf-4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL136450, CD364651, CN314421, DN999740, U32645
      Consensus CDS
      CCDS14617.1
      UniProtKB/Swiss-Prot
      Q99607
      Related
      ENSP00000311280, OTTHUMP00000024003, ENST00000308167, OTTHUMT00000058243
      Conserved Domains (2) summary
      pfam12310
      Location:1 – 104
      Blast Score: 373
      Elf-1_N; Transcription factor protein N terminal
      cl02599
      Location:208 – 290
      Blast Score: 400
      Ets; Ets-domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      129198895..129244688, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      118596924..118641306, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL136450.8 CAI42882.1
      CAI42883.1
    genomic AL136450.8 CAI42882.1
      CAI42883.1
    genomic CH471107.2 EAX11813.1
      EAX11814.1
    genomic Z81363.2 CAI42371.1
      CAI42372.1
    mRNA AF000670.1 AAC17452.1
    mRNA AK314972.1 None
    mRNA BC017194.2 AAH17194.1
    mRNA BC114355.1 None
    mRNA BC114356.1 None
    mRNA CD364651.1 None
    mRNA CN314421.1 None
    mRNA DN999740.1 None
    mRNA U32645.1 AAB53693.1
    other-genetic DQ892234.2 ABM83160.1
    other-genetic DQ895435.2 ABM86361.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99607.1 GenPept UniProtKB/Swiss-Prot:Q99607
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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