My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4 [ Homo sapiens ]

    Gene ID: 199746, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    U2AF1L4provided by HGNC
    Official Full Name
    U2 small nuclear RNA auxiliary factor 1-like 4provided by HGNC
    Primary source
    HGNC:23020
    See related
    Ensembl:ENSG00000161265; HPRD:03050; MIM:601080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    U2af26; U2AF1L3; U2AF1RS3; U2AF1-RS3; U2AF1L3V1; FLJ35525; MGC33901
    Help top of page

    Genomic context

    Location :
    19q13.12
    Sequence :
    Chromosome: 19; NC_000019.9 (36233428..36236336, complement)
    See U2AF1L4 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia 4 Neighboring gene IGF-like family receptor 1 Neighboring gene presenilin enhancer 2 homolog (C. elegans) Neighboring gene lin-37 homolog (C. elegans)

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Functional dissection of an enhancer-like element located within the second intron of the human U2AF1L4 gene. Didych DA, et al. Biochemistry (Mosc), 2011 Aug. PMID 22022969.
    2. Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes. Ash MR, et al. Structure, 2010 Aug 11. PMID 20696395.
    3. Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26. Heyd F, et al. J Biol Chem, 2008 Jul 11. PMID 18460468.
    4. Cloning and characterization of a novel splice variant of human Rab18 gene (RAB18). Dou T, et al. DNA Seq, 2005 Jun. PMID 16147880.
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.

    See all (10) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. One of the conservative regions is responsible for the enhancer activity and is able to interact with proteins of HeLa cell nuclear extract.
      Title: Functional dissection of an enhancer-like element located within the second intron of the human U2AF1L4 gene.
    2. Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26
      Title: Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:128270 BioGRID:117520 GIGYF2    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    splicing factor U2AF 26 kDa subunit
    Names
    splicing factor U2AF 26 kDa subunit
    U2AF1-like protein 3
    U2 auxiliary factor 26
    U2 small nuclear RNA auxiliary factor 1-like 3
    U2(RNU2) small nuclear RNA auxiliary factor 1-like 3
    U2 small nuclear RNA auxiliary factor 1-like protein 3
    U2 small nuclear RNA auxiliary factor 1-like protein 4
    U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040425.1 → NP_001035515.1  splicing factor U2AF 26 kDa subunit isoform 1

      Status: VALIDATED

      Source sequence(s)
      AI767079, AY569437, BM696851
      Consensus CDS
      CCDS42551.1
      UniProtKB/Swiss-Prot
      Q8WU68
      Related
      ENSP00000368258, ENST00000378975
      Conserved Domains (2) summary
      cd00590
      Location:40 – 102
      Blast Score: 102
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      cl11592
      Location:13 – 39
      Blast Score: 77
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    2. NM_144987.2 → NP_659424.2  splicing factor U2AF 26 kDa subunit isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI767079, BC021186, BM696851, CD175846
      Consensus CDS
      CCDS12473.1
      UniProtKB/Swiss-Prot
      Q8WU68
      Related
      ENSP00000292879, ENST00000292879
      Conserved Domains (2) summary
      cd00590
      Location:40 – 102
      Blast Score: 108
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      cl11592
      Location:13 – 39
      Blast Score: 88
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      36233428..36236336, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      32738416..32741324, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AD000671.1 (38039..40912) None
    mRNA AI767079.1 None
    mRNA AK092844.1 BAC03988.1
    mRNA AK094213.1 None
    mRNA AK303983.1 BAG64901.1
    mRNA AY461582.1 None
    mRNA AY569437.3 AAT72770.3
    mRNA BC010865.1 None
    mRNA BC021186.1 AAH21186.1
    mRNA BC049208.1 None
    mRNA BC062474.1 None
    mRNA BM696851.1 None
    mRNA CD175846.1 None
    other-genetic DQ892422.2 ABM83348.1
    other-genetic DQ895636.2 ABM86562.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NAD5 GenPept UniProtKB/TrEMBL:Q8NAD5
    Q8WU68.2 GenPept UniProtKB/Swiss-Prot:Q8WU68
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...