ELF1 E74-like factor 1 (ets domain transcription factor) [Homo sapiens] - Gene

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Summary

Official Symbol: ELF1provided by HGNC
Official Full Name: E74-like factor 1 (ets domain transcription factor)provided by HGNC
Primary source: HGNC:3316
Locus tag: RP11-2P5.1
See related: Ensembl:ENSG00000120690; HPRD:01808; MIM:189973; Vega:OTTHUMG00000016783
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

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Genomic context

Location :: 13q13

Sequence :: Chromosome: 13; NC_000013.10 (41506055..41593508, complement)

See ELF1 in Epigenomics, MapViewer

Chromosome 13 - NC_000013.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that Elf-1 may modulate breast cancer progression to some extent without having an impact on survival of breast cancer patients.
Title: Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome.
Expression of FLI-1, ELF-1, and GABP activated the PF4 promoter in HepG2 cells.
Title: Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site.
The expression of Elf-1 and survivin in non-small cell lung cancer is related to differentiation, lymphatic metastasis, clinical stage, and prognosis, and both are positively correlated with microvessel density.
Title: Expression of Elf-1 and survivin in non-small cell lung cancer and their relationship to intratumoral microvessel density.
the results indicate that insufficient O-GlcNAc modification prevents Elf-1-mediated transcriptional repression and thereby upregulates Tollip gene expression in intestinal epithelial cells.
Title: Transcription of the Tollip gene is elevated in intestinal epithelial cells through impaired O-GlcNAcylation-dependent nuclear translocation of the negative regulator Elf-1.
through a genome-wide association in a Hong Kong Chinese cohort and replication in 2 other Asian populations, identified association of ELF1 with systemic lupus erythematosus
Title: ELF1 is associated with systemic lupus erythematosus in Asian populations.
The expression levels of both Elf-1 and VEGF were significantly related with tumor differentiation, lymphatic metastasis, clinical stage, and postoperative survival time in non-small cell lung cancer.
Title: [Expression and significance of Elf-1 and vascular endothelial growth factor in non-small cell lung cancer].
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: ELF1 is associated with systemic lupus erythematosus in Asian populations.
ETS transcription factor ELF1 is an important positive regulator of MEIS1 expression
Title: Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Data show that VEGFR1 promoter binding sites for ELF-1, CREB and EGR-1/3 play a positive role in gene transcription in endothelial cells.
Title: Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo.

Submit: New GeneRIF Correction See all (15)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

ELF1 is associated with systemic lupus erythematosus in Asian populations.

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Products	Interactant	Other Gene	Source	Pubs	Description
P32519	P17096	HMGA1	HPRD	PubMed
P32519	P19838	NFKB1	HPRD	PubMed
P32519	P25208	NFYB	HPRD	PubMed
P32519	P06400	RB1	HPRD	PubMed
P32519	Q04864	REL	HPRD	PubMed
P32519	P08047	SP1	HPRD	PubMed
BioGRID:108312	BioGRID:109402	HMGA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108312	BioGRID:110857	NFKB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108312	BioGRID:110866	NFYA	BioGRID	PubMed	Reconstituted Complex
BioGRID:108312	BioGRID:111898	REL	BioGRID	PubMed	Reconstituted Complex
BioGRID:108312	BioGRID:112550	SP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108312	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108312	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
negative regulation of T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
regulation of cytokine production	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IC Inferred by Curator more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: ETS-related transcription factor Elf-1

Names: ETS-related transcription factor Elf-1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145353.1 → NP_001138825.1 ETS-related transcription factor Elf-1 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the mid coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AK304289, AL157877, BX640798, M82882

Consensus CDS

CCDS45043.1

UniProtKB/TrEMBL

B4E2I5

UniProtKB/TrEMBL

E9PDQ9

UniProtKB/TrEMBL

Q6MZZ4

Related

ENSP00000405580, ENST00000442101

Conserved Domains (2) summary

pfam12310
Location:1 – 111
Blast Score: 271

Elf-1_N; Transcription factor protein N terminal

cl02599
Location:183 – 265
Blast Score: 405

Ets; Ets-domain
NM_172373.3 → NP_758961.1 ETS-related transcription factor Elf-1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AL157877, BC030507, BX640798, DC418141, M82882

Consensus CDS

CCDS9374.1

UniProtKB/Swiss-Prot

P32519

UniProtKB/TrEMBL

Q6MZZ4

Related

ENSP00000239882, OTTHUMP00000018310, ENST00000239882, OTTHUMT00000044654

Conserved Domains (2) summary

pfam12310
Location:1 – 111
Blast Score: 269

Elf-1_N; Transcription factor protein N terminal

cl02599
Location:207 – 289
Blast Score: 407

Ets; Ets-domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000013.10 Reference GRCh37.p5 Primary Assembly

Range

41506055..41593508, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000145.1 Alternate HuRef

Range

22305948..22394169, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL157877.11	CAI13220.1
		CAI13221.1
genomic	CH471075.1	EAX08640.1
		EAX08641.1
mRNA	AK095466.1	BAG53061.1
mRNA	AK304289.1	BAG65147.1
mRNA	BC010575.1	None
mRNA	BC030507.2	AAH30507.1
mRNA	BQ722965.1	None
mRNA	BX640798.1	CAE45881.1
mRNA	DC418141.1	None
mRNA	M82882.1	None
other-genetic	DQ891709.2	ABM82635.1
other-genetic	DQ894886.2	ABM85812.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P32519.2	GenPept	UniProtKB/Swiss-Prot:P32519
Q5T9E7	GenPept	UniProtKB/TrEMBL:Q5T9E7
Q6MZZ4	GenPept	UniProtKB/TrEMBL:Q6MZZ4