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Rpe65 retinal pigment epithelium 65 [ Mus musculus (house mouse) ]

Gene ID: 19892, updated on 24-May-2016
Official Symbol
Rpe65provided by MGI
Official Full Name
retinal pigment epithelium 65provided by MGI
Primary source
MGI:MGI:98001
See related
Ensembl:ENSMUSG00000028174 Vega:OTTMUSG00000052823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LCA2; RP20; rd12; 65kDa; Mord1; A930029L06Rik
Orthologs
Location:
3 H4; 3 82.52 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (159599075..159625307)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (159262145..159288271)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40187 Neighboring gene DEP domain containing 1a Neighboring gene wntless homolog (Drosophila) Neighboring gene succinate dehydrogenase complex, subunit B, iron sulfur (Ip) pseudogene Neighboring gene calponin 2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity ISO
Inferred from Sequence Orthology
more info
 
all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinal isomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cellular response to electrical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of light stimulus involved in visual perception ISO
Inferred from Sequence Orthology
more info
 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural retina development ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
regulation of rhodopsin gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
retina homeostasis ISO
Inferred from Sequence Orthology
more info
 
retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
retinal metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
retinal metabolic process ISO
Inferred from Sequence Orthology
more info
 
retinol metabolic process ISO
Inferred from Sequence Orthology
more info
 
visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell body ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
retinoid isomerohydrolase
Names
all-trans-retinyl-palmitate hydrolase
modifier of retinal degeneration 1
retinal pigment epithelium, 65 kDa
retinal pigment epithelium-specific 65 kDa protein
retinol isomerase
NP_084263.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029987.2NP_084263.2  retinoid isomerohydrolase

    See identical proteins and their annotated locations for NP_084263.2

    Status: VALIDATED

    Source sequence(s)
    BC090656, CJ133618
    Consensus CDS
    CCDS38683.1
    UniProtKB/Swiss-Prot
    Q91ZQ5
    Related
    ENSMUSP00000143654, OTTMUSP00000070514, ENSMUST00000196999, OTTMUST00000132202
    Conserved Domains (1) summary
    pfam03055
    Location:20530
    RPE65; Retinal pigment epithelial membrane protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

    Range
    159599075..159625307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240045.1XP_011238347.1  

    See identical proteins and their annotated locations for XP_011238347.1

    Conserved Domains (1) summary
    pfam03055
    Location:20531
    RPE65; Retinal pigment epithelial membrane protein
  2. XM_006501165.2XP_006501228.1  

    See identical proteins and their annotated locations for XP_006501228.1

    Conserved Domains (1) summary
    pfam03055
    Location:20531
    RPE65; Retinal pigment epithelial membrane protein

RNA

  1. XR_375503.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000025.1 Alternate Mm_Celera

    Range
    166038618..166064587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)