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Ros1 Ros1 proto-oncogene [ Mus musculus (house mouse) ]

Gene ID: 19886, updated on 28-May-2016
Official Symbol
Ros1provided by MGI
Official Full Name
Ros1 proto-oncogeneprovided by MGI
Primary source
MGI:MGI:97999
See related
Ensembl:ENSMUSG00000019893 Vega:OTTMUSG00000026453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ros-1; c-ros
Orthologs
Location:
10 B3; 10 26.18 cM
Exon count:
44
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (52044865..52195397, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (51765732..51915050, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40646 Neighboring gene vestigial like family member 2 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene discoidin, CUB and LCCL domain containing 1 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene golgi associated PDZ and coiled-coil motif containing

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
cell growth ISO
Inferred from Sequence Orthology
more info
 
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
columnar/cuboidal epithelial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of phosphate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction by protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
proto-oncogene tyrosine-protein kinase ROS
Names
c-Ros receptor tyrosine kinase
c-ros-1
proto-oncogene c-Ros
proto-oncogene c-Ros-1
receptor tyrosine kinase c-ros oncogene 1
NP_035412.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011282.2NP_035412.2  proto-oncogene tyrosine-protein kinase ROS precursor

    See identical proteins and their annotated locations for NP_035412.2

    Status: VALIDATED

    Source sequence(s)
    AC153950, AC155831
    Consensus CDS
    CCDS23838.1
    UniProtKB/Swiss-Prot
    Q78DX7
    Related
    ENSMUSP00000020045, OTTMUSP00000032607, ENSMUST00000020045, OTTMUST00000065421
    Conserved Domains (3) summary
    cd00063
    Location:207291
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:19482208
    Pkinase_Tyr; Protein tyrosine kinase
    cd05044
    Location:19482209
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    52044865..52195397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243147.1XP_011241449.1  

    Conserved Domains (3) summary
    cd00063
    Location:207291
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:19492209
    Pkinase_Tyr; Protein tyrosine kinase
    cd05044
    Location:19492210
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    52882450..53031104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)