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Rfx3 regulatory factor X, 3 (influences HLA class II expression) [ Mus musculus (house mouse) ]

Gene ID: 19726, updated on 8-May-2016
Official Symbol
Rfx3provided by MGI
Official Full Name
regulatory factor X, 3 (influences HLA class II expression)provided by MGI
Primary source
MGI:MGI:106582
See related
Ensembl:ENSMUSG00000040929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRFX3; C230093O12Rik
Orthologs
Location:
19; 19 C1
Exon count:
20
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (27761718..28011698, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (27836211..28085656, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C030016D13 gene Neighboring gene predicted gene, 35697 Neighboring gene THO complex 3 pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene chr19_428.1 Neighboring gene UPF0729 protein C18orf32 homolog

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cilium-dependent cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cilium movement involved in determination of left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
type B pancreatic cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
transcription factor complex IC
Inferred by Curator
more info
PubMed 
Preferred Names
transcription factor RFX3
Names
regulatory factor X 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166414.1NP_001159886.1  transcription factor RFX3

    See identical proteins and their annotated locations for NP_001159886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC118005, AK030008, AK140928
    Consensus CDS
    CCDS29725.1
    UniProtKB/Swiss-Prot
    P48381
    Related
    ENSMUSP00000126313, ENSMUST00000165566
    Conserved Domains (2) summary
    pfam02257
    Location:184260
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:1140
    RFX1_trans_act; RFX1 transcription activation region
  2. NM_011265.3NP_035395.2  transcription factor RFX3

    See identical proteins and their annotated locations for NP_035395.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AC118005, AK030008, AK041120, AK140928
    Consensus CDS
    CCDS29725.1
    UniProtKB/Swiss-Prot
    P48381
    Related
    ENSMUSP00000133461, OTTMUSP00000054439, ENSMUST00000174850, OTTMUST00000097173
    Conserved Domains (2) summary
    pfam02257
    Location:184260
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:1140
    RFX1_trans_act; RFX1 transcription activation region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    27761718..28011698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526783.2XP_006526846.1  

    See identical proteins and their annotated locations for XP_006526846.1

    UniProtKB/TrEMBL
    G5E890
    Related
    ENSMUSP00000038760, OTTMUSP00000054438, ENSMUST00000046898, OTTMUST00000097172
    Conserved Domains (2) summary
    pfam02257
    Location:150235
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:1140
    RFX1_trans_act; RFX1 transcription activation region
  2. XM_006526784.2XP_006526847.1  

    See identical proteins and their annotated locations for XP_006526847.1

    UniProtKB/TrEMBL
    G5E890
    Conserved Domains (2) summary
    pfam02257
    Location:150235
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:1140
    RFX1_trans_act; RFX1 transcription activation region
  3. XM_011247169.1XP_011245471.1  

    See identical proteins and their annotated locations for XP_011245471.1

    UniProtKB/Swiss-Prot
    P48381
    Conserved Domains (2) summary
    pfam02257
    Location:184260
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:1140
    RFX1_trans_act; RFX1 transcription activation region
  4. XM_006526778.2XP_006526841.1  

    See identical proteins and their annotated locations for XP_006526841.1

    Conserved Domains (2) summary
    pfam02257
    Location:210286
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:27166
    RFX1_trans_act; RFX1 transcription activation region
  5. XM_006526782.2XP_006526845.1  

    See identical proteins and their annotated locations for XP_006526845.1

    UniProtKB/Swiss-Prot
    P48381
    Related
    ENSMUSP00000134141, OTTMUSP00000054440, ENSMUST00000172907, OTTMUST00000097175
    Conserved Domains (2) summary
    pfam02257
    Location:184260
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:1140
    RFX1_trans_act; RFX1 transcription activation region
  6. XM_006526780.2XP_006526843.1  

    Conserved Domains (2) summary
    pfam02257
    Location:194270
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:11150
    RFX1_trans_act; RFX1 transcription activation region
  7. XM_011247168.1XP_011245470.1  

    Conserved Domains (2) summary
    pfam02257
    Location:176261
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:27166
    RFX1_trans_act; RFX1 transcription activation region
  8. XM_011247167.1XP_011245469.1  

    See identical proteins and their annotated locations for XP_011245469.1

    Conserved Domains (2) summary
    pfam02257
    Location:210286
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:27166
    RFX1_trans_act; RFX1 transcription activation region
  9. XM_006526785.2XP_006526848.1  

    Conserved Domains (1) summary
    pfam02257
    Location:127
    RFX_DNA_binding; RFX DNA-binding domain
  10. XM_011247170.1XP_011245472.1  

    Related
    ENSMUSP00000133367, OTTMUSP00000054441, ENSMUST00000173863, OTTMUST00000097176
    Conserved Domains (2) summary
    pfam02257
    Location:210286
    RFX_DNA_binding; RFX DNA-binding domain
    pfam04589
    Location:27166
    RFX1_trans_act; RFX1 transcription activation region

RNA

  1. XR_877668.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    28539554..28762791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)