Format

Send to:

Choose Destination

Ret ret proto-oncogene [ Mus musculus (house mouse) ]

Gene ID: 19713, updated on 28-May-2016
Official Symbol
Retprovided by MGI
Official Full Name
ret proto-oncogeneprovided by MGI
Primary source
MGI:MGI:97902
See related
Ensembl:ENSMUSG00000030110 Vega:OTTMUSG00000056769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTC; RET9; RET51; c-Ret
Orthologs
Location:
6 55.86 cM; 6 E3-F1
Exon count:
19
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (118151748..118197744, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (118101766..118147762, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RasGEF domain family, member 1A Neighboring gene microRNA 7044 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene RIKEN cDNA 1700069P05 gene Neighboring gene predicted gene, 30557

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
Peyer's patch morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
embryonic epithelial tube formation IDA
Inferred from Direct Assay
more info
PubMed 
embryonic epithelial tube formation IGI
Inferred from Genetic Interaction
more info
PubMed 
enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
innervation ISO
Inferred from Sequence Orthology
more info
 
membrane protein proteolysis ISO
Inferred from Sequence Orthology
more info
 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
neuron cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of metanephric glomerulus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron maturation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of serine phosphorylation of STAT3 protein IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of serine phosphorylation of STAT3 protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of serine phosphorylation of STAT3 protein IDA
Inferred from Direct Assay
more info
PubMed 
response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
ureter maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
endosome membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
proto-oncogene tyrosine-protein kinase receptor Ret
Names
proto-oncogene c-Ret
NP_001074249.1
NP_033076.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080780.1NP_001074249.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor

    See identical proteins and their annotated locations for NP_001074249.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longer transcript but encodes the shorter isoform (c). This isoform is also known as Ret9.
    Source sequence(s)
    AC135861, AC156396, BC059012
    Consensus CDS
    CCDS39608.1
    UniProtKB/Swiss-Prot
    P35546
    Related
    ENSMUSP00000086169, OTTMUSP00000073467, ENSMUST00000088790, OTTMUST00000140076
    Conserved Domains (3) summary
    cd05045
    Location:7241013
    PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
    cd11304
    Location:173268
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam07714
    Location:7251006
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_009050.2NP_033076.2  proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor

    See identical proteins and their annotated locations for NP_033076.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 3' coding region, compared to variant 4. The resulting protein (isoform a) has a longer, distinct C-terminus compared to isoform c. This isoform is also known as Ret51.
    Source sequence(s)
    AC135861, AC156396, BC059012
    Consensus CDS
    CCDS20470.1
    UniProtKB/Swiss-Prot
    P35546
    Related
    ENSMUSP00000032201, OTTMUSP00000073466, ENSMUST00000032201, OTTMUST00000140075
    Conserved Domains (3) summary
    cd05045
    Location:7241013
    PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
    cd11304
    Location:173268
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam07714
    Location:7251006
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    118151748..118197744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    119974414..120020450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)