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Renbp renin binding protein [ Mus musculus (house mouse) ]

Gene ID: 19703, updated on 8-May-2016
Official Symbol
Renbpprovided by MGI
Official Full Name
renin binding proteinprovided by MGI
Primary source
MGI:MGI:105940
See related
Ensembl:ENSMUSG00000031387 Vega:OTTMUSG00000017682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Age; Rnbp
Orthologs
Location:
X A7.3; X 37.49 cM
Exon count:
11
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (73922121..73930850, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71167460..71176189, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene arginine vasopressin receptor 2 Neighboring gene Rho GTPase activating protein 4 Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene host cell factor C1 Neighboring gene predicted gene 8545

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
N-acylglucosamine 2-epimerase activity IDA
Inferred from Direct Assay
more info
PubMed 
N-acylglucosamine 2-epimerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
N-acylglucosamine 2-epimerase activity ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
purine nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
N-acetylglucosamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
N-acetylglucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
N-acetylmannosamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
N-acetylneuraminate catabolic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
N-acylglucosamine 2-epimerase
Names
GlcNAc 2-epimerase
N-acetyl-D-glucosamine 2-epimerase
renin-binding protein
NP_001158176.1
NP_075621.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164704.1NP_001158176.1  N-acylglucosamine 2-epimerase isoform 2

    See identical proteins and their annotated locations for NP_001158176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK167648, BF456232, BY082557
    Consensus CDS
    CCDS57763.1
    UniProtKB/Swiss-Prot
    P82343
    Related
    ENSMUSP00000110020, OTTMUSP00000019679, ENSMUST00000114379, OTTMUST00000043827
    Conserved Domains (1) summary
    cd00249
    Location:15394
    AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...
  2. NM_023132.3NP_075621.3  N-acylglucosamine 2-epimerase isoform 1

    See identical proteins and their annotated locations for NP_075621.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK146652, BF456232, BY082557
    Consensus CDS
    CCDS41015.2
    UniProtKB/Swiss-Prot
    P82343
    Related
    ENSMUSP00000112277, OTTMUSP00000019265, ENSMUST00000116578, OTTMUST00000042880
    Conserved Domains (1) summary
    cd00249
    Location:15408
    AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    73922121..73930850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247550.1XP_011245852.1  

    Conserved Domains (1) summary
    cd00249
    Location:1334
    AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...
  2. XM_006527916.1XP_006527979.1  

    Conserved Domains (1) summary
    cd00249
    Location:1269
    AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    65174555..65183285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)