Ren1 renin 1 structural [Mus musculus] - Gene

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Summary

Official Symbol: Ren1provided by MGI
Official Full Name: renin 1 structuralprovided by MGI
Primary source: MGI:97898
See related: Ensembl:ENSMUSG00000070645; Vega:OTTMUSG00000021617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d; D19352

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Genomic context

Location :: 1 E4; 1 69.9 cM

Sequence :: Chromosome: 1; NC_000067.6 (133350674..133360320)

See Ren1 in Epigenomics, MapViewer

Chromosome 1 - NC_000067.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

VAMP2 and VAMP3 are expressed in JG cells, but only VAMP2 is targeted to renin-containing granules and mediates the stimulatory effect of cAMP on renin exocytosis.
Title: Vesicle-associated membrane protein-2 (VAMP2) mediates cAMP-stimulated renin release in mouse juxtaglomerular cells.
genetic disruption of beta-adrenergic receptors reduces basal renin expression along the developing preglomerular tree and in adult kidneys
Title: Renin expression in large renal vessels during fetal development depends on functional beta1/beta2-adrenergic receptors.
In addition to its direct effect on renin gene transcription, PPARgamma "sensitizes" renin gene to cAMP via trans-activation of AC6 gene.
Title: PPARgamma-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of cAMP on renin gene expression.
The present study demonstrated activation of renal COX-2 and renin expression in diabetic KK-A(y) mice at different stages.
Title: Immunohistochemical examination of cyclooxygenase-2 and renin in a KK-A(y) mouse model of diabetic nephropathy.
Renin-angiotensin-aldosterone system components are upregulated under endothelin blockade.
Title: Endothelin-1 receptor blockade induces upregulation of renin-angiotensin-aldosterone system expression in terms of blood pressure regulation.
cathepsin B-deficient mice exhibit no differences compared with controls in their ability to generate active renin, and our results do not support CTSB as the processing enzyme in mice
Title: Cathepsin B is not the processing enzyme for mouse prorenin.
PPARgamma appears to be a relevant transcription factor for the control of renin gene in juxtaglomerular cells
Title: Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells.
preservation of intracellular renin expression in the brain is not sufficient to compensate for a loss of secreted Ren, and sRen plays a pivotal role in renal development and function, survival, and the regulation of arterial pressure
Title: Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin.
Replacement of connexin 40 by connexin 45 causes ectopic localization of renin-producing cells in the kidney but maintains in vivo control of renin gene expression.
Title: Replacement of connexin 40 by connexin 45 causes ectopic localization of renin-producing cells in the kidney but maintains in vivo control of renin gene expression.
the expression and secretion of renin are regulated under a complex series of hormonal and metabolic determinants in mature 3T3-L1 adipocytes
Title: Regulated renin release from 3T3-L1 adipocytes.

Submit: New GeneRIF Correction See all (33)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (4) 1 citation
Targeted (other) (1) 1 citation
Targeted (Reporter) (2) 1 citation
Targeted (knock-in) (1) 1 citation

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Function	Evidence Code	Pubs
aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
endopeptidase activity	ISO Inferred from Sequence Orthology more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
peptidase activity	ISO Inferred from Sequence Orthology more info
receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
angiotensin maturation	IMP Inferred from Mutant Phenotype more info	PubMed
angiotensin maturation	ISO Inferred from Sequence Orthology more info
cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
drinking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
NOT establishment of blood-nerve barrier	IMP Inferred from Mutant Phenotype more info	PubMed
hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
kidney development	ISO Inferred from Sequence Orthology more info
metabolic process	IDA Inferred from Direct Assay more info	PubMed
proteolysis	ISO Inferred from Sequence Orthology more info
regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
regulation of blood pressure	ISO Inferred from Sequence Orthology more info
regulation of blood volume by renin-angiotensin	IMP Inferred from Mutant Phenotype more info	PubMed
renin-angiotensin regulation of aldosterone production	IDA Inferred from Direct Assay more info	PubMed
response to cAMP	ISO Inferred from Sequence Orthology more info
response to cGMP	ISO Inferred from Sequence Orthology more info
response to drug	ISO Inferred from Sequence Orthology more info
response to organic substance	IDA Inferred from Direct Assay more info	PubMed
response to stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cytoplasmic part	ISO Inferred from Sequence Orthology more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info
intracellular	IDA Inferred from Direct Assay more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
soluble fraction	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: renin-1

Names: renin-1; renin b; kidney renin; aspartyl-protease; angiotensinogenase

NP_112469.1

EC 3.4.23.15

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031192.3 → NP_112469.1 renin-1 precursor

Status: VALIDATED

Source sequence(s)

AC068906, AK085309

Consensus CDS

CCDS15295.1

UniProtKB/Swiss-Prot

P06281

Related

ENSMUSP00000092135, OTTMUSP00000024128, ENSMUST00000094556, OTTMUST00000051330

Conserved Domains (3) summary

pfam07966
Location:29 – 54
Blast Score: 102

A1_Propeptide; A1 Propeptide

pfam00026
Location:83 – 401
Blast Score: 1025

Asp; Eukaryotic aspartyl protease

cl11403
Location:76 – 401
Blast Score: 1552

pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases.

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 129S6/SvEvTac

Genomic

NT_039192.2 Reference GRCm38 129S6/SvEvTac

Range

129184..138826, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38 C57BL/6J

Genomic

NC_000067.6 Reference GRCm38 C57BL/6J

Range

133350674..133360320

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000023.1 Alternate Mm_Celera

Range

135963151..135972797

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC034108.26 (129185..138806)	None	129S6/SvEvTac
genomic	AC068906.14 (89022..98651)	None	C57BL/6J
genomic	CH466520.2	EDL39650.1	mixed
genomic	K02596.1	AAA40045.1
genomic	K02800.1	AAA40044.1
genomic	L78789.1	None	BALB/cJ
genomic	M32352.1	AAA40043.1
genomic	M34190.1	AAA40042.1	C57BL/10
genomic	X00810.1	CAA25391.1
genomic	X00811.1	None
genomic	X00812.1	None
genomic	X00813.1	None
genomic	X00814.1	None
genomic	X00815.1	None
genomic	X00816.1	None
genomic	X00850.1	None
genomic	X00851.1	None
mRNA	AF117821.1	AAD26253.1	C57BL
mRNA	AK052685.1	BAC35094.1	C57BL/6J
mRNA	AK085309.1	BAC39418.1	C57BL/6J
mRNA	BC024331.1	None	FVB/N
mRNA	BC061053.1	AAH61053.1
mRNA	X16642.1	CAA34636.1	BALB/c