Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

AHSG alpha-2-HS-glycoprotein [ Homo sapiens (human) ]

Gene ID: 197, updated on 8-Apr-2014
Official Symbol
AHSGprovided by HGNC
Official Full Name
alpha-2-HS-glycoproteinprovided by HGNC
Primary source
HGNC:349
Locus tag
PRO2743
See related
Ensembl:ENSG00000145192; HPRD:00727; MIM:138680; Vega:OTTHUMG00000156605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AHS; A2HS; HSGA; FETUA
Summary
Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]
Location :
3q27
Sequence :
Chromosome: 3; NC_000003.12 (186613061..186621318)
See AHSG in Epigenomics, MapViewer

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 11 Neighboring gene uncharacterized LOC100287402 Neighboring gene fetuin B Neighboring gene histidine-rich glycoprotein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
kinase inhibitor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acute-phase response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of insulin receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
ossification IEA
Inferred from Electronic Annotation
more info
 
pinocytosis NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of bone mineralization NAS
Non-traceable Author Statement
more info
PubMed 
regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal system development NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
blood microparticle IDA
Inferred from Direct Assay
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
alpha-2-HS-glycoprotein
Names
alpha-2-HS-glycoprotein
fetuin-A
alpha-2-Z-globulin
ba-alpha-2-glycoprotein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011436.1 RefSeqGene

    Range
    5001..13258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001622.2NP_001613.2  alpha-2-HS-glycoprotein preproprotein

    See proteins identical to NP_001613.2

    Status: REVIEWED

    Source sequence(s)
    BC048198, D67012, DC362553, M16961
    Consensus CDS
    CCDS3278.1
    UniProtKB/Swiss-Prot
    P02765
    Related
    ENSP00000393887, OTTHUMP00000210158, ENST00000411641, OTTHUMT00000344761
    Conserved Domains (1) summary
    cd00042
    Location:28120
    Blast Score: 115
    CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38 Primary Assembly

    Range
    186613061..186621318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000135.1 Alternate HuRef

    Range
    183739917..183748174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    186294812..186303069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...